The Atlantic

The First Man to Have His Genes Edited Inside His Body

A clinical trial for zinc-finger nucleases, a potential new method of curing genetic diseases, kicks off.
Source: Eric Risberg / AP

Updated on November 15 at 12:37 p.m ET

On Monday, 44-year-old Brian Madeux spent three hours hooked up to an IV and made scientific history.

The clear liquid that dripped into his arm set off a chain of events that is supposed to end with the precise insertion of a gene that Madeux has lacked since birth into, a genetic disorder that causes a range of symptoms including joint stiffness,  breathing problems, and developmental delay. Madeux has had 26 surgeries to deal with it all.

You’re reading a preview, subscribe to read more.

More from The Atlantic

The Atlantic4 min read
Your Phone Has Nothing on AM Radio
This article was featured in the One Story to Read Today newsletter. Sign up for it here. There is little love lost between Senator Ted Cruz and Representative Rashida Tlaib. She has called him a “dumbass” for his opposition to the Paris Climate Agre
The Atlantic5 min read
The Strangest Job in the World
This is an edition of the Books Briefing, our editors’ weekly guide to the best in books. Sign up for it here. The role of first lady couldn’t be stranger. You attain the position almost by accident, simply by virtue of being married to the president
The Atlantic8 min readAmerican Government
The Most Consequential Recent First Lady
This article was featured in the One Story to Read Today newsletter. Sign up for it here. The most consequential first lady of modern times was Melania Trump. I know, I know. We are supposed to believe it was Hillary Clinton, with her unbaked cookies

Related Books & Audiobooks