No, cow milk in baby formula doesn’t up diabetes risk

While past research has suggested cow's milk in baby formula could increase children's risk of type 1 diabetes, a new long-term study shows otherwise.

Drinking formula made with cow’s milk does not increase children’s risk of developing type 1 diabetes, according to the results of a 15-year global study of children genetically predisposed to developing the disease.

The findings provide a long-awaited answer to the question of whether infant formula made with cow’s milk plays a role in the development of type 1 diabetes, according to researchers.

“The question was whether delaying the exposure to complex foreign proteins will decrease the risk of diabetes. The answer is no…”

“Previous studies have indicated that early exposure to complex foreign proteins, such as the proteins in cow’s milk, may increase the risk of type 1 diabetes in people with genetic risk for the disease,” says study author Neil H. White, a professor of pediatrics and of medicine at Washington University School of Medicine in St. Louis.

“The question was whether delaying the exposure to complex foreign proteins will decrease the risk of diabetes. The answer is no,” White says.

In the US, about 200,000 people under the age of 20 have type 1 diabetes, an autoimmune disease caused when the pancreas stops producing the hormone insulin, which regulates the body’s blood-sugar levels.

Beginning in 2002, White and his research colleagues examined 2,159 infants in 15 countries. Each infant had a family member affected by type 1 diabetes, as well as a genetic propensity for the disease that was determined with a blood test given at birth.

Researchers assigned the babies randomly to one of two formulas designed for the study. A group of 1,078 infants received a conventional cow’s-milk-based formula with the cow’s-milk proteins intact, while a second group of 1,081 infants consumed a formula in which the cow’s-milk proteins were split into small pieces known as peptides. That formula—called hydrolyzed-casein formula—mimics the body’s process of digestion, breaking down proteins into tiny parts.

Researchers followed the children for about 11.5 years. During that time, each infant received his or her assigned formula for at least two months and until the age of 6 to 8 months. During that time, researchers asked parents to avoid allowing the baby to ingest cow’s-milk proteins from any other food sources.

Of the infants who consumed the conventional cow’s-milk formula, 82 (7.6 percent) eventually developed diabetes. For those who received the hydrolyzed-casein formula, 91 (8.4 percent) developed the disease.

“This study shows no statistically significant difference between the groups in terms of how many of these children developed diabetes; therefore, it helps provide a long-awaited, definitive answer to the controversy regarding the potential role of cow’s-milk formula in the development of type 1 diabetes,” says White, who directs the Pediatric Clinical Research Unit at Washington University and treats patients at St. Louis Children’s Hospital.

“It also indicates there is no evidence to revise the current dietary recommendations for infants at high risk for type 1 diabetes,” he adds.

The National Institute of Child Health and Development and the National Institute of Diabetes and Digestive and Kidney Diseases, both of the National Institutes of Health (NIH); the Canadian Institutes of Health Research; JDRF; and the Commission of the European Communities provided funding for the research.

Additional support came from the EFSD/JDRF/Novo Nordisk Focused Research Grant, the Academy of Finland, the Dutch Diabetes Research Foundation, and the Finnish Diabetes Research Foundation. Mead Johnson Nutrition provided the study formulas.

The researchers report their findings in JAMA.

Source: Washington University in St. Louis

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