NPR

Ketamine, A Promising Depression Treatment, Seems To Act Like An Opioid

A Stanford research team finds that ketamine's ability to quickly relieve depression depends on activating the brain's opioid system. The finding raises new questions about the drug's safety.
These PET scans show the normal distribution of opioid receptors in the human brain. A new study suggests ketamine may activate these receptors, raising concern it could be addictive.

A new study suggests that ketamine, an increasingly popular treatment for depression, has something in common with drugs like fentanyl and oxycodone.

The small study found evidence that ketamine's effectiveness with depression, demonstrated in many small studies over the past decade, comes from its interaction with the brain's opioid system. A Stanford University team reported their findings Wednesday in The American Journal of Psychiatry.

"We think, one of the study's authors and a professor of psychiatry and behavioral sciences at Stanford. "That's why you're getting these rapid effects."

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