NPR

Researchers Find A Web Of Factors Behind Multiple Sclerosis

It's looking like MS strikes when a variety of triggers gang up to impair neurons in the brain and spinal cord. Researchers are using their new knowledge to search for treatments.
A scanning electron micrograph shows microglial cells (yellow) ingesting branched oligodendrocyte cells (purple), a process thought to occur in multiple sclerosis. Oligodendrocytes form insulating myelin sheaths around nerve axons in the central nervous system.

As the story goes, nearly 80 years ago on the Faroe Islands - a stark North Atlantic archipelago 200 miles off the coast of Scotland — a neurologic epidemic may have washed, or rather convoyed, ashore.

Before 1940 the incidence of multiple sclerosis on the Faroes was near, if not, zero, according to the tantalizing lore I recall from medical school. Yet in the years following British occupation of the islands during World War II, the rate of MS rose dramatically, leading many researchers to assume the outbreak was caused by some unknown germ transmitted by the foreign soldiers.

We now know that MS is not infectious in the true sense of the word. It is not contagious in the way, say, the flu is.

But infection does likely play a role in MS.

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