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    A Simple Guide to Cushing's Syndrome and Related Conditions
    A Simple Guide to Cushing's Syndrome and Related Conditions
    A Simple Guide to Cushing's Syndrome and Related Conditions
    Ebook22 pages17 minutes

    A Simple Guide to Cushing's Syndrome and Related Conditions

    By Kenneth Kee

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    About this ebook

    Cushing’s Syndrome

    What is Cushing’s syndrome?

    Cushing’s syndrome is a disease which is caused by the exposure of the body to excessive quantities of glucocorticoids steroids.

    People of all ages are affected but more are seen in females between 30 to 50 years of age.

    What are the causes of Cushing Syndrome?

    The causes are believed to be:
    1. Cushing Disease -excessive production of adrenocorticotrophin hormone (ACTH) by the pituitary gland causes bilateral adrenal (gland above kidney) hyperplasia (overgrowth of gland tissue).

    The enlarged adrenal gland will produce excessive corticosteroids.

    A pituitary basophile or chromphobe adenoma may be present.

    2. Adrenal tumors which may be benign or malignant can produce excessive corticosteroids

    3. Ectopic ACTH syndrome

    Production of ACTH by a tumor such as cancer of the lung leads to adrenal hyperplasia

    4. Iatrogenic -patients receiving excessive doses of corticosteroids may present as Cushing syndrome

    What are the symptoms of Cushing Syndrome?

    Symptoms of Cushing Syndrome:
    1. Obesity predominally truncal often with pad of fat between shoulders (buffalo hump)

    2. Round flat plethoric (red) face (moon face)

    3. Skin is thin and bruises easily

    4. Purple striae on abdomen, thighs, and shoulders.

    5. Proximal myopathy leads to difficulty in getting out of chairs and walking upstairs

    6. Excessive adrenal androgen secretions lead to hirsutism, amenorrhea and acne

    7. Osteoporosis can lead to back pain

    8. Hypertension and glycosuria (glucose in urine) are common

    9. Depression and other psychiatric disturbance common

    10. In children there may stunting of growth

    11. Women with Cushing syndrome often have:
    a. Excess hair growth on the face, neck, chest, abdomen, and thighs
    b. Menstrual cycles that are irregular or stops

    12. Men may have:
    a. Impotence
    b. Reduced or no desire for sex

    How is the Diagnosis of Cushing Syndrome made?

    Diagnosis of Cushing Syndrome:
    1. The typical moon face and buffalo hump can suggest the diagnosis of Cushing Syndrome

    2. 24 hour urine cortisol tests

    3. Overnight dexamethasone suppression test

    4. Plasma ACTH level

    5. Chest X-ray to exclude lung cancer

    6. X-ray of pituitary fossa to exclude pituitary tumors

    7. Ultrasound of adrenal glands for enlargement

    What are the complications of Cushing Syndrome?

    Complications of Cushing Syndrome:
    1. Hypertension

    2. Fractures from osteoporosis

    3. Stunted growth in children

    What is the treatment of Cushing’s syndrome?

    Treatment of Cushing’s syndrome:
    Cushing's syndrome is treated by surgery, radiation treatments or drugs.

    Often if there is a tumor on just one adrenal gland, the other gland often becomes smaller and stops normal hormone production

    Hormone supplements are always given before any surgical treatment and should be taken for months after surgery until the second adrenal gland recovers its normal function.

    1. Anti-adrenal drug such as aminogluthemide
    This drug blocks the production of steroids formed from cholesterol.
    It is clinically used in the treatment of Cushing's syndrome and metastatic breast cancer.

    2. Bilateral adrenalectomy

    3. Surgery to remove pituitary tumor

    4. Surgery to remove primary neoplasm in lungs or pancreas

    5. In cases of adrenal gland cancer, chemotherapy and radiation can also be used to treat the cancer.
    Surgery is a last resort.

    6. In iatrogenic Cushing’s syndrome, reduction of ingestion of corticosteroids to the lowest dosage possible has to done to control the illness.

    TABLE OF CONTENT

    Chapter 1

    Cushing’s Syndrome

    Chapter 2

    Adrenal Tumors

    Chapter 3

    Corticosteroids

    Chapter 4

    Epilogue

    LanguageEnglish
    PublisherKenneth Kee
    Release dateOct 15, 2013
    ISBN9781301654932
    A Simple Guide to Cushing's Syndrome and Related Conditions
    Author

    Kenneth Kee

    Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

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      Book preview

      A Simple Guide to Cushing's Syndrome and Related Conditions - Kenneth Kee

      A

      Simple

      Guide

      to

      Cushing’s Syndrome

      And

      Related

      Diseases

      by

      Dr Kenneth Kee

      M.B.,B.S. (Singapore)

      Ph.D (Healthcare Administration)

      Copyright Kenneth Kee 2013 Smashwords Edition

      Published By Kenneth Kee at Smashwords.com

      Dedication

      This book is dedicated

      to my wife Dorothy

      and my children

      Carolyn, Grace

      and Kelvin

      This book describes the Cushing Syndrome and Related Diseases such as Adrenal tumors and Corticosteroids which are seen in some of my patients in my Family Clinic.

      This eBook is licensed for your personal enjoyment only. This eBook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each reader.

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