Neurology Multiple Choice Questions With Explanations: Volume II
By Dr P A Shah
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Neurology Multiple Choice Questions With Explanations - Dr P A Shah
EEG
CHAPTER 1 - APPROACH
1.
A 60-year-old patient presents with pain, numbness, and an impaired sensation over half of the face, along with ataxia, nystagmus, dysphagia, and hoarseness of the voice. His pain and thermal sensations on the opposite half of his body are impaired. Horner’s syndrome is present. The likely cause of the disease is thrombosis of which vessel? (AIIMS)
AICA (anterior inferior cerebellar artery)
PICA (posterior inferior cerebellar artery)
Basilar artery
Pontine vessels
DISCUSSION:
This is a clinical presentation of lateral medullary syndrome. It presents with the following features on the side of the lesion: cerebellar ataxia, decreased skin sensation in the ipsilateral half of the face, Horner’s syndrome, vertigo, and weakness of the soft palate, larynx, and pharynx. On the opposite side of the body, there is numbness due to the involvement of the spinothalamic tract.
Lateral medullary (Wallenberg) syndrome is commonly seen due to thrombosis of the vertebral and posterior inferior cerebellar arteries.
ANSWER:
‘PICA (posterior inferior cerebellar artery).’
REFERENCES:
English JD, Johnston SC. Chapter 370. Cerebrovascular Diseases. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison’s Principles of Internal Medicine. 18th edition; 2012.
Bates D. Chapter 24.9. Brainstem syndromes. In: Warrell DA, Cox TM, Firth JD, eds. Oxford Textbook of Medicine. 5th edition; 2010.
2.
A patient receiving therapy for pulmonary tuberculosis develops generalized tonic–clonic seizures. Which of the following antitubercular drugs is most likely to produce seizures? (AIIMS)
Rifampicin
Isoniazid (INH)
Pyrazinamide
Ethambutol
DISCUSSION:
Isoniazid (INH) is most often associated with nervous system side effects, most prominently peripheral neuropathy, psychosis, and seizures. Other side effects of antitubercular drugs involving the nervous system include optic neuropathy with ethambutol, ototoxicity, and neuromuscular blockade with aminoglycosides.
Rifampicin is mainly associated with hepatitis, while pyrazinamide is associated with joint pain and hepatitis.
ANSWER:
‘Isoniazid (INH).’
REFERENCES:
Kass JS1, Shandera WX. Nervous system effects of antituberculosis therapy. CNS Drugs. 2010 Aug;24(8):655-67.
Perkin G D. Chapter 24.5.1. Epilepsy in later childhood and adulthood. In: Warrell DA, Cox TM, Firth JD, eds. Oxford Textbook of Medicine. 5th edition; 2010.
3.
A 75-year-old woman was admitted to hospital after having suffered a cerebrovascular accident. On physical examination it was found that she was not responding to any visual, auditory, or tactile stimuli on the left side of her body. In addition, she had a deficit involving only the inferior portion of the left visual field in both eyes. A CT scan showed a non-hemorrhagic infarction in the right hemisphere. Which lobe of this patient’s brain had been principally affected by the stroke? (AIIMS)
Frontal
Occipital
Parietal
Temporal
DISCUSSION:
This patient had non-dominant parietal lobe involvement. Parietal lobe lesions are associated with contralateral hemisensory loss, astereognosis, agraphesthesia, and contralateral homonymous lower quadrantanopia. In addition, dominant parietal lobe lesions show a combination of finger agnosia, acalculia, and right-left confusion, while non-dominant parietal lobe lesions are associated with hemispatial neglect, spatial disorientation, constructional apraxia, and dressing apraxia.
ANSWER:
‘Parietal.’
REFERENCES:
Gijn van J. Chapter 24.10.1. Stroke: cerebrovascular disease. In: Warrell DA, Cox TM, Firth JD, eds. Oxford Textbook of Medicine. 5th edition; 2010.
English JD, Johnston SC. Chapter 370. Cerebrovascular Diseases. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison’s Principles of Internal Medicine. 18th edition; 2012.
4.
A patient experiences loss of central vision in both eyes followed by a throbbing, unilateral headache. He is suffering from: (AIIMS)
Amaurosis fugax
Classical migraine
Tension headache
Delirium tremens
DISCUSSION:
This is a typical presentation of classical migraine, which is characterized by an aura followed by a unilateral, throbbing headache, sometimes associated with nausea and vomiting.
Tension headache is featureless. Amaurosis fugax is not associated with headache. Delirium tremens is an acute confusional state precipitated by alcohol withdrawal.
ANSWER:
‘Classical migraine.’
REFERENCES:
Ivan Garza I et al. Chapter 69. Headache and Other Craniofacial Pain. In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC. eds. Bradley’s Neurology in Clinical Practice, 6th edition; 2012.
Ropper AH, Samuels MA, Klein JP. Chapter 10. Headache and Other Craniofacial Pains. In: Ropper AH, Samuels MA, Klein JP. eds. Adams & Victor’s Principles of Neurology, 10th edition; 2014.
5.
A 65-year-old woman has had several episodes consisting of impaired vision in her right eye and numbness of the left side of her body, each lasting up to 4–5 minutes. Which of the following is the likely cause? (PGI)
Internal carotid artery insufficiency
Posterior cerebral artery aneurysm rupture
Parasagittal meningioma
Frontal lobe tumor
DISCUSSION:
Involvement of the internal carotid artery is often suggested by the presence of hemispheric signs (like hemiparesis or hemianesthesia) on one side and recurrent transient monocular blindness or amaurosis fugax (due to ophthalmic artery involvement) on the other side.
Aneurysm rupture usually produces sudden onset, severe symptoms. Parasagittal meningioma and frontal lobe tumor both produce slowly progressive symptoms. Parasagittal meningioma often produces paraparesis, while frontal lobe tumor may produce contralateral hemiparesis.
ANSWER:
‘Internal carotid artery insufficiency.’
REFERENCES:
Gijn van J. Chapter 24.10.1. Stroke: cerebrovascular disease. In: Warrell DA, Cox TM, Firth JD, eds. Oxford Textbook of Medicine. 5th edition; 2010.
English JD, Johnston SC. Chapter 370. Cerebrovascular Diseases. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison’s Principles of Internal Medicine. 18th edition; 2012.
6.
The combinations of disorientation, polyneuritis, loss of recent memory, and a tendency to confabulate are most likely due to: (AIIMS)
Pernicious anemia
Charcot–Marie–Tooth disease
Alcoholism
Tabes dorsalis
DISCUSSION:
An important effect of chronic alcohol misuse is Wernicke–Korsakoff syndrome. It results from damage to the mamillary bodies, dorsomedial nuclei of the thalamus, and adjacent areas of the periventricular grey matter caused by a deficiency of thiamin (vitamin B1). In addition, peripheral neuropathy is a common complication of alcoholism due to both nutritional deficiency