Pharmacokinetics: A Tutorial Study Guide: Science Textbook Series
()
About this ebook
"Pharmacokinetics" is a book chapter of the college-level textbook for the book volume in the Principles of Neuropsychopharmacology course. It is a part of the Science Textbook Series authored by Nicoladie Tam, Ph.D. that also includes the Principles of Biology course.
This book is written with specific pedagogical considerations to facilitate students' learning. It applies the proven best practices to motivate students in learning. It uses multiple pedagogical methodologies to engage students in active learning by participating in the knowledge acquisition process. It stimulates the curiosity of students by asking them questions and answering them immediately. It guides the students in their comprehension of knowledge by using examples and by giving them detailed explanations following the answers.
Nicoladie Tam
Dr. Nicoladie Tam, Ph.D., is a writer and a professor who does research in emotions and the brain. She is an expert in neuropsychology, neurophysiology, brain imaging, computational neuroscience, and bioengineering. She has a Ph.D. degree in Physiology, and three Bachelor of Science degrees in Computer Science, Physics and Astrophysics. She has also been a suicide and crisis counselor, with extensive counseling experience in relationships and crisis management. She is also a life coach, who does relationship coaching and executive coaching, inspires others in achieving the very best.
Read more from Nicoladie Tam
Executive Functions: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsSynapse: A Tutorial Study Guide Rating: 3 out of 5 stars3/5Respiratory System: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Nervous System: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsBrain Imaging Techniques: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsNeuropsychopharmacology: An Introduction: A Tutorial Study Guide: Science Textbook Series Rating: 0 out of 5 stars0 ratingsRenal System: A Tutorial Study Guide Rating: 4 out of 5 stars4/5Anxiety Disorders: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Neurotransmitter: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Schizophrenia: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Immune System: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsEndocrine System: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Pharmacology: An Introduction: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Amphetamine: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsADHD: Attention Deficit Hyperactivity Disorder: A Tutorial Study Guide Rating: 3 out of 5 stars3/5Digestive System: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsScientific Methods: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Action Potential: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsNeuron: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Reproductive System: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Circulatory System: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsBiological Principles: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsDose-Response Curve: A Tutorial Study Guide: Science Textbook Series Rating: 0 out of 5 stars0 ratingsCognitive Learning: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsNeurotransmitter Pathways: A Tutorial Study Guide Rating: 0 out of 5 stars0 ratingsAlcohol and Alcoholism Rating: 0 out of 5 stars0 ratingsMotor System: A Tutorial Study Guide: Science Textbook Series Rating: 0 out of 5 stars0 ratingsAffective Disorders: Depression, Mania and Bipolar Disorder: A Tutorial Study Guide Rating: 3 out of 5 stars3/5Neurobiological Mechanisms of Learning Rating: 0 out of 5 stars0 ratings
Related to Pharmacokinetics
Related ebooks
Pharmacokinetics: A Tutorial Study Guide Rating: 2 out of 5 stars2/5Pharmacology: An Introduction: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists Rating: 5 out of 5 stars5/5Neuropsychopharmacology: An Introduction: A Tutorial Study Guide: Science Textbook Series Rating: 0 out of 5 stars0 ratingsPathophysiology for Pharmacy Rating: 4 out of 5 stars4/5Handbook of Pharmacology Rating: 0 out of 5 stars0 ratingsGuidelines and Screening Methods of Pharmacology Rating: 0 out of 5 stars0 ratingsPharmacology in Drug Discovery: Understanding Drug Response Rating: 0 out of 5 stars0 ratingsClinical Research: Principles, Practice and Perspective Rating: 0 out of 5 stars0 ratingsClinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics Rating: 0 out of 5 stars0 ratingsMedicines Management for Nurses at a Glance Rating: 0 out of 5 stars0 ratingsPharmacoepidemiology and Pharmacovigilance: Synergistic Tools to Better Investigate Drug Safety Rating: 5 out of 5 stars5/5Endocrine System: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Pharmacology Review Study Guide for Exams Rating: 0 out of 5 stars0 ratingsPrinciples of Clinical Pharmacology Rating: 3 out of 5 stars3/5Renal System: A Tutorial Study Guide Rating: 4 out of 5 stars4/5Basic Pharmacology Rating: 3 out of 5 stars3/5Atkinson's Principles of Clinical Pharmacology Rating: 0 out of 5 stars0 ratingsRevising basic and clinical pharmacology: eBook Rating: 0 out of 5 stars0 ratingsNeurotransmitter Pathways: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Pharmacology: Principles and Practice Rating: 5 out of 5 stars5/5Experimental approaches to Biopharmaceutics and Pharmacokinetics Rating: 0 out of 5 stars0 ratingsDatabook for Clinical Pharmacology Rating: 5 out of 5 stars5/5Basic Pharmacology And Drug Calculations [Practice Questions And Answers] Rating: 4 out of 5 stars4/5Neurotransmitter: A Tutorial Study Guide Rating: 5 out of 5 stars5/5Pharmacology in Clinical Practice Rating: 5 out of 5 stars5/5Senior Pharmacist: Passbooks Study Guide Rating: 0 out of 5 stars0 ratingsLearn Pharmacology In One Week Rating: 0 out of 5 stars0 ratings
Medical For You
The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Rating: 5 out of 5 stars5/5Herbal Healing for Women Rating: 4 out of 5 stars4/5What Happened to You?: Conversations on Trauma, Resilience, and Healing Rating: 4 out of 5 stars4/5Mediterranean Diet Meal Prep Cookbook: Easy And Healthy Recipes You Can Meal Prep For The Week Rating: 5 out of 5 stars5/5The Emperor of All Maladies: A Biography of Cancer Rating: 5 out of 5 stars5/5Brain on Fire: My Month of Madness Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5Women With Attention Deficit Disorder: Embrace Your Differences and Transform Your Life Rating: 5 out of 5 stars5/5The Song of the Cell: An Exploration of Medicine and the New Human Rating: 4 out of 5 stars4/5Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies Rating: 4 out of 5 stars4/5The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5Adult ADHD: How to Succeed as a Hunter in a Farmer's World Rating: 4 out of 5 stars4/5The People's Hospital: Hope and Peril in American Medicine Rating: 4 out of 5 stars4/5The Lost Book of Simple Herbal Remedies: Discover over 100 herbal Medicine for all kinds of Ailment Inspired By Barbara O'Neill Rating: 0 out of 5 stars0 ratingsThe Art of Dying Well: A Practical Guide to a Good End of Life Rating: 4 out of 5 stars4/5A Letter to Liberals: Censorship and COVID: An Attack on Science and American Ideals Rating: 3 out of 5 stars3/5Living Daily With Adult ADD or ADHD: 365 Tips o the Day Rating: 5 out of 5 stars5/5ATOMIC HABITS:: How to Disagree With Your Brain so You Can Break Bad Habits and End Negative Thinking Rating: 5 out of 5 stars5/5Hidden Lives: True Stories from People Who Live with Mental Illness Rating: 4 out of 5 stars4/5Tight Hip Twisted Core: The Key To Unresolved Pain Rating: 4 out of 5 stars4/5The Big Fat Surprise: Why Butter, Meat and Cheese Belong in a Healthy Diet Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5The Hormone Reset Diet: Heal Your Metabolism to Lose Up to 15 Pounds in 21 Days Rating: 4 out of 5 stars4/5Working Stiff: Two Years, 262 Bodies, and the Making of a Medical Examiner Rating: 4 out of 5 stars4/5
Reviews for Pharmacokinetics
0 ratings0 reviews
Book preview
Pharmacokinetics - Nicoladie Tam
Table of Contents
Table of Contents
Pharmacokinetics
Objectives
Concepts to Learn
1.1.Route of Administration
Objectives
Concepts to Learn
Summary
Q&A
What is pharmacokinetics?
What is pharmacodynamics?
What is the route of administration of a drug?
What are the characteristics of oral administration?
What is the rate-limiting step of drug distribution through the oral administration route?
Why is it important to understand the effect of the rate-limiting step in gastric emptying?
What is the advantage of oral administration for drug recall in case of overdose?
What are the characteristics of sublingual administration?
What are the characteristics of inhalation administration?
How fast does the drug reach its target site in inhalation compared to the intravenous route?
What are the characteristics of intravenous (IV) administration?
What are the characteristics of intraperitoneal (IP) administration?
What are the characteristics of intracranial (IC) administration?
What are the characteristics of intramuscular (IM) administration?
What are the characteristics of subcutaneous administration?
What are the characteristics of topical administration?
What are the characteristics of snorting?
Review Question
1.2.Effect of Drug Ionization
Objectives
Concepts to Learn
Summary
Q&A
How does the lipid solubility of a drug affect its absorption?
How does ionization relate to lipid solubility?
How does the ionization of a drug affect the absorption rate?
How does the ionization of a drug affect the acidity of the medium it is in?
What are the pH levels of different body fluid compartments?
How does the passage of Aspirin™ in the stomach lining uni-directional and get trapped once absorbed?
Review Questions
1.3.Drug Distribution
Objectives
Concepts to Learn
Summary
Q&A
How do drug molecules distribute once administered into the body?
What is vasoconstriction?
What is depot binding?
What does a silent receptor do?
What are the disadvantages of depot binding?
What are the advantages of depot binding?
Review Questions
1.4.Half-Life of Drugs
Objectives
Concepts to Learn
Summary
Q&A
What is a drug half-life?
What causes the half-life?
How can the phenomenon of half-life be explained?
Why is half-life always a constant for a particular drug?
What does the length of half-life tell us about the characteristic property of a drug?
What does a short half-life mean?
Why are there different half-lives for different drugs?
How is half-life represented graphically?
Does half-life depend on the initial concentration?
How many half-lives does it take to reduce the concentration of a drug to 1/8 of its initial amount?
What is the concentration of a drug after 3 half-lives?
What is the shape of the half-life plotting in a linear plot?
What is the shape of the half-life plotting in a semi-log plot?
How is half-life used to determine the dosage intervals for administering a drug?
When a drug is administered at each half-life interval, the concentration will accumulate gradually, how long does it take to reach a steady-state level?
Does it take a different amount of time to reach this steady state if the therapeutic steady-state dosage is different?
Can a drug have multiple half-lives?
Is the concentration of the drug administered the same as the concentration at the target site?
How do we determine what concentration is needed to administer to reach the concentration at the target level?
What does therapeutic drug monitoring (TDM) determine?
How does drug testing detect drug usage if the drug half-life is very short?
Review Questions
Critical Thinking Questions
Drug Testing and Truth Table
Objectives
Concept to Learn
Summary
Q&A
How does drug testing detect drug usage if the drug half-life is very short?
Is drug testing always accurate?
What is a truth table?
How can the truth table be applied in drug testing?
What is a true positive?
What is true negative?
What is a false positive?
What is a false negative?
What is a false alarm?
Review Questions
Critical Thinking Questions
Drug Elimination
Objectives
Concepts to Learn
Summary
Q&A
What are the two major routes of drug elimination?
What are the physiological mechanisms for drug excretion in the kidneys?
What is renal clearance?
What other organs can excrete drugs from the system?
What are the factors that affect the reabsorption of drugs in the nephrons?
How are drugs metabolized?
What is biotransformation?
Which organ does most of the metabolism of drug molecules?
How are drugs metabolized in the liver?
What is a synthetic reaction?
What