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Natural Products Isolation: Separation Methods for Antimicrobials, Antivirals and Enzyme Inhibitors
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This new book encompasses, in great detail, the most recent progress made in the isolation and separation of natural products. It covers antibiotics, marine and plant-derived substances, enzyme inhibitors and interferons. The most recent separation methodology is described. Although there is a bias toward antibiotics, it was done because this is still the largest natural products area of research.
The fourteen chapters are written by experts in their respective fields. The first two chapters are largely devoted to new methodology applied to purification of a variety of compounds. They include an extensive review and new applications of counter-current chromatography and the newly emerging HPLC-photodiode array technology. Chapter 3 provides a review of affinity chromatography applied to the separation of antibiotics for the first time. Next are chapters on antimicrobials with an update on all the most recent -lactam (after 1976) discoveries. A comprehensive review of a very important class of antiparasitic agents - the avermectins - follows. An update of isolation and purification of a variety of marine-derived compounds is next. The succeeding chapter is a comprehensive review of the most recent developments in isolation and purification of interferons. This is followed by a discussion of enzyme inhibitors and their isolation and purification and ties in with a chapter on plant-derived natural products, some of which are also in this same category. The final chapter is a futuristic essay indicating the isolation of minute amounts of natural products and the fascinating biological properties which they possess.
The book has extensive isolation schemes, tables, figures and chemical structures. In many instances a short summary of the producing organism, brief chemical description and structure and biological activity of the compounds is presented. Detailed information of extraction, separation and purification techniques follow. Each chapter has an extensive bibliography and, where applicable, an appendix showing sources of materials and equipment. A detailed index to the subject matter is included at the end of the book.
The book thus offers the reader: up-to-date reviews (including 1988) of specific topics in the natural products field not to be found elsewhere; information on new chromatographic methods and techniques described in sufficient detail to be utilized by investigators in this area of research; and extensive references to enable the serious researcher to pursue particular information. It will appeal to pharmaceutical and natural products researchers and is a valuable acquisition for university chemistry and biochemistry departments.
The fourteen chapters are written by experts in their respective fields. The first two chapters are largely devoted to new methodology applied to purification of a variety of compounds. They include an extensive review and new applications of counter-current chromatography and the newly emerging HPLC-photodiode array technology. Chapter 3 provides a review of affinity chromatography applied to the separation of antibiotics for the first time. Next are chapters on antimicrobials with an update on all the most recent -lactam (after 1976) discoveries. A comprehensive review of a very important class of antiparasitic agents - the avermectins - follows. An update of isolation and purification of a variety of marine-derived compounds is next. The succeeding chapter is a comprehensive review of the most recent developments in isolation and purification of interferons. This is followed by a discussion of enzyme inhibitors and their isolation and purification and ties in with a chapter on plant-derived natural products, some of which are also in this same category. The final chapter is a futuristic essay indicating the isolation of minute amounts of natural products and the fascinating biological properties which they possess.
The book has extensive isolation schemes, tables, figures and chemical structures. In many instances a short summary of the producing organism, brief chemical description and structure and biological activity of the compounds is presented. Detailed information of extraction, separation and purification techniques follow. Each chapter has an extensive bibliography and, where applicable, an appendix showing sources of materials and equipment. A detailed index to the subject matter is included at the end of the book.
The book thus offers the reader: up-to-date reviews (including 1988) of specific topics in the natural products field not to be found elsewhere; information on new chromatographic methods and techniques described in sufficient detail to be utilized by investigators in this area of research; and extensive references to enable the serious researcher to pursue particular information. It will appeal to pharmaceutical and natural products researchers and is a valuable acquisition for university chemistry and biochemistry departments.
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Porous Silica Rating: 0 out of 5 stars0 ratingsAffinity Chromatography Rating: 0 out of 5 stars0 ratingsChemical Derivatization in Gas Chromatography Rating: 0 out of 5 stars0 ratingsSelective Gas Chromatographic Detectors Rating: 1 out of 5 stars1/5Liquid Chromatography Detectors Rating: 0 out of 5 stars0 ratingsGradient Elution in Column Liquid Chromatography: Theory and Practice Rating: 0 out of 5 stars0 ratingsElectron Capture: Theory and Practice in Chromatography Rating: 0 out of 5 stars0 ratingsPolymer Characterization by Liquid Chromatography Rating: 0 out of 5 stars0 ratingsAnalytical Artifacts: GC, MS, HPLC, TLC and PC Rating: 0 out of 5 stars0 ratingsQuantitative Gas Chromatography for Laboratory Analyses and On-Line Process Control Rating: 0 out of 5 stars0 ratingsPreparative Liquid Chromatography Rating: 0 out of 5 stars0 ratingsNatural Products Isolation: Separation Methods for Antimicrobials, Antivirals and Enzyme Inhibitors Rating: 0 out of 5 stars0 ratingsAqueous Size-Exclusion Chromatography Rating: 0 out of 5 stars0 ratingsChromatography of Lipids in Biomedical Research and Clinical Diagnosis Rating: 0 out of 5 stars0 ratingsTrace Metal Analysis and Speciation Rating: 1 out of 5 stars1/5Stationary Phases in Gas Chromatography Rating: 0 out of 5 stars0 ratingsRetention and Selectivity in Liquid Chromatography: Prediction, Standardisation and Phase Comparisons Rating: 0 out of 5 stars0 ratingsEmerging Technologies in Protein and Genomic Material Analysis Rating: 0 out of 5 stars0 ratingsLiquid Chromatography in Biomedical Analysis Rating: 0 out of 5 stars0 ratingsCapillary Electrophoresis: Principles, Practice and Applications Rating: 0 out of 5 stars0 ratingsAdvances in LC-MS Instrumentation Rating: 0 out of 5 stars0 ratingsHyphenated Techniques in Supercritical Fluid Chromatography and Extraction Rating: 0 out of 5 stars0 ratingsChromatography of Mycotoxins: Techniques and Applications Rating: 0 out of 5 stars0 ratingsGas Chromatography in Air Pollution Analysis Rating: 0 out of 5 stars0 ratingsBioaffinity Chromatography Rating: 0 out of 5 stars0 ratingsCarbohydrate Analysis: High Performance Liquid Chromatography and Capillary Electrophoresis Rating: 0 out of 5 stars0 ratings
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Natural Products Isolation - Elsevier Science
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