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    An Outline of Energy Metabolism in Man
    An Outline of Energy Metabolism in Man
    An Outline of Energy Metabolism in Man
    Ebook119 pages1 hour

    An Outline of Energy Metabolism in Man

    By Gordon L. Atkins

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    About this ebook

    An Outline of Energy Metabolism in Man provides an overview of the whole energy metabolic process among humans. The book is comprised of seven chapters that are organized according to the lecture series conducted by the author. The text first covers the basic principles of metabolism, and then proceeds to covering catabolism and resynthesis of simple units. Next, the book tackles the storage forms and control mechanisms. The remaining chapters detail the integration of pathways within cells and the metabolism of the body as a whole. The text will be of great use to students of biochemistry and other related fields, such as nutrition and nursing.
    LanguageEnglish
    PublisherElsevier Science
    Release dateOct 22, 2013
    ISBN9781483182919
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      Book preview

      An Outline of Energy Metabolism in Man - Gordon L. Atkins

      An outline of energy metabolism in man

      Gordon L Atkins

      Department of Biochemistry, University of Edinburgh Medical School

      Table of Contents

      Cover image

      Title page

      Copyright

      Preface

      Author’s note

      Chapter 1: BASIC PRINCIPLES

      Publisher Summary

      1.1 General outline of metabolism

      1.2 Major fuels and their contribution to energy production

      1.3 High energy compounds

      1.4 Uses of ATP

      1.5 Cell structure and energy metabolism

      Chapter 2: CATABOLISM OF SIMPLE UNITS

      Publisher Summary

      2.1 Overview of catabolism

      2.2 Oxidative phosphorylation

      2.3 The citric acid cycle (Krebs cycle)

      2.4 β-oxidation of free fatty acids

      2.5 Glycolysis (the Embden-Meyerhof pathway)

      2.6 Anaerobic glycolysis

      2.7 Amino acid catabolism

      Chapter 3: RESYNTHESIS OF SIMPLE UNITS

      Publisher Summary

      3.1 Gluconeogenesis

      3.2 Free fatty acid synthesis

      3.3 Sources of NADPH for free fatty acid synthesis

      3.4 Ketone body metabolism

      3.5 Lipoprotein metabolism

      Chapter 4: STORAGE FORMS

      Publisher Summary

      4.1 Triacylglycerols

      4.2 Glycogen

      4.3 Protein

      Chapter 5: CONTROL MECHANISMS

      Publisher Summary

      5.1 Control by hormones

      5.2 Control by key enzymes

      5.3 Control of enzyme concentration

      Chapter 6: INTEGRATION OF PATHWAYS WITHIN CELLS

      Publisher Summary

      6.1 Metabolism by different tissues

      6.2 Oxidation of free fatty acids

      6.3 Formation of ketone bodies

      6.4 Oxidation of ketone bodies

      6.5 Oxidation of amino acids

      6.6 Gluconeogenesis from amino acids

      6.7 Oxidation of glucose

      6.8 Conversion of glucose into free fatty acids

      6.9 Glycogen metabolism

      Chapter 7: WHOLE BODY METABOLISM

      Publisher Summary

      7.1 Whole body metabolism

      7.2 The fasted state: 6 to 24 hours

      7.3 The fasted state: 2 to 4 days

      7.4 The fasted state: over 2 weeks

      7.5 Fasted and exercised

      7.6 The fed state

      APPENDIX

      Some suggestions for further reading

      Index

      Copyright

      William Heinemann Medical Books Ltd

      23 Bedford Square

      London WC1B 3HH

      First published 1981

      Copyright © Gordon L Atkins 1981

      ISBN 0 433 00950 0

      Typeset by D. P. Media Limited, Hitchin, Herts.

      Printed in Great Britain by

      R. J. Acford Ltd, Chichester, West Sussex

      Preface

      This account of energy metabolism is based on a set of lectures that I have given for several years as part of a course organised by the Postgraduate Board of Medicine, University of Edinburgh for the benefit of anaesthetists preparing for Part 1 of the FFA RCS. I have been prompted to write it partly because many of those attending the course have suggested that a book such as this would be useful to them and none is currently available. I am also aware that energy metabolism is taught at this level to many students who are not biochemists, for example anaesthetists, nutritionists, nurses, etc. This book is also written for them.

      In the presentation of the material, the basic principle I wish to convey is that material flows smoothly, and in a controlled manner, through several pathways to achieve certain objectives. I wish to avoid rigid compartmentalization of the subject, which most textbooks employ, and to do this I make extensive use of diagrams. As a result, this account is only a framework or outline with most of the detail, especially enzymes and less important intermediates, omitted.

      The presentation here follows the pattern of the lecture series. It is a logical development in which, first, the various conventional pathways available to a cell for the metabolism of the three major fuels in man (carbohydrate, fat and protein) are discussed. Then there is a short account of the more important control mechanisms and this is followed by a discussion of the overall pathways in relation to the specialized functions of the various organs. Finally, the objective of the book is reached and the metabolism of the body as a whole is presented.

      Author’s note

      Since this book was written the compound fructose diphosphate has become known as

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