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    Gene therapy: Potential Applications of Nanotechnology
    Unavailable
    Gene therapy: Potential Applications of Nanotechnology
    Unavailable
    Gene therapy: Potential Applications of Nanotechnology
    Ebook432 pages

    Gene therapy: Potential Applications of Nanotechnology

    By Surendra Nimesh

    ()

    Currently unavailable

    Currently unavailable

    About this ebook

    Gene therapy is emerging as a new class of therapeutics for the treatment of inherited and acquired diseases. However, poor cellular uptake and instability of DNA in the physiological milieu limits its therapeutic potential, hence a vector which can protect and efficiently transport DNA to the target cells must be developed. Nanotechnology-based non-viral vectors have been proposed as potential candidates. Various polymeric nanoparticles have been shown to be suitable, with high cellular uptake efficiencies and reduced cytotoxicity. These delivery vectors form condensed complexes with DNA which result in shielding against enzymatic degradation and enhanced cellular targeting. Advantages including easy manipulatibility, high stability, low cost and high payload, mean that nanoparticles from various polymers have been exploited. Gene therapy gives a systematic account of the many aspects of nanotechnology mediated gene therapy, from the preparation of nanoparticles to physicochemical characterization, and follows with applications in in vitro and in vivo models. This book emphasizes the various aspects of nanotechnology-based gene therapy, with initial chapters detailing the tools and techniques available for preparation and in vitro and in vivo characterization of nanoparticles. Later chapters provide exhaustive details on polymeric systems employed for gene therapy.
    • Provides an overview of nanotechnology applications in gene therapy, from preparation of nanoparticles to in vitro and in vivo studies
    • Details the tools and techniques available for preparation, characterization and in vitro and in vivo study of nanoparticles
    • Details the limitations of nanoparticle-mediated gene therapy and proposes ways in which they may be overcome
    LanguageEnglish
    PublisherElsevier Science
    Release dateOct 31, 2013
    ISBN9781908818645
    Unavailable
    Gene therapy: Potential Applications of Nanotechnology
    Author

    Surendra Nimesh

    Dr. Surendra Nimesh did PhD in nanotechnology from Dr. B.R. Ambedkar Center for Biomedical Science Research, University of Delhi and CSIR-Institute of Genomics and Integrative Biology, Delhi, India. He did postdoctorate at Ecole Polytechnique of Montreal, Montreal; Clinical Research Institute of Montreal, Montreal and Health Canada, Ottawa, Canada. He has published several research and review articles and authored/coauthored seven books that includes two Elsevier books: The Design and Development of Novel Drugs and Vaccines (2021) and Gene Therapy: Potential Applications of Nanotechnology (2013). He is an internationally recognized expert of nanotechnology for biological applications with specialization in drug and gene delivery.

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