Complementary and Alternative Medical Lab Testing Part 10: Obstetrics
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About this ebook
Complementary and Alternative Medical Lab Testing (CAM Labs) contains summaries of the published research on lab tests, primarily from PubMed trials on humans. Each chapter (disease) begins with a brief summary of conventional lab tests, followed by additional lab tests, including diabetes, insulin resistance, metabolic syndrome, inflammation, etc. There are sections on endocrine hormones (thyroid, adrenal, sex steroids) and environmental medicine (toxic heavy metals). The nutritional assessments section includes minerals, vitamins and amino acids.
CAM Labs 10 – Obstetrics
1. Gestational Diabetes
2. Miscarriage
3. Nausea And Vomiting Of Pregnancy
4. Postpartum Depression
5. Preeclampsia
6. Pregnancy-Associated Hypertension
7. Pregnancy (Prenatal)
8. Recurrent Pregnancy Loss
Ronald Steriti
Dr. Ronald Steriti is a graduate of Southwest College of Naturopathic Medicine and currently is researcher for Jonathan V. Wright at the Tahoma Clinic.
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Complementary and Alternative Medical Lab Testing Part 10 - Ronald Steriti
Complementary and Alternative
Medical Lab Testing
Part 10: Obstetrics
By Ronald Steriti, ND, PhD
©
Complementary and Alternative Medical Lab Testing Clinician’s Guide Part 10: Obstetrics
By Ronald Steriti, ND, PhD
Copyright © 2016
All rights reserved. No part of this book may be reproduced in any form or by any means, including photocopying, including in a web site, or stored in a retrieval system, or transmitted in any form by any means, without expressed, written permission of the copyright owner.
The contents of this document are the sole property of the author.
Disclaimer
This book has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
The information contained in this book is for educational purposes only, and should not be construed as medical advice or instruction. No action should be taken based solely on the contents of this book. Readers should consult appropriate health officials.
While extensive efforts have been made to ensure the accuracy of the information contained, the possibility of errors, omissions, and misinterpretations cannot be ruled out. The reader is advised to consult the original references for verification and clarification.
Foreward
This book is a summary the published research on lab tests, primarily from PubMed. The studies are limited to those with trials on humans. As such, some labs may be excluded due to the lack of published research. That is simply a reflection of the current state of research - much more work is needed!
Although this book may be useful for differential diagnosis, lab tests are can also be used to identify inderlying causes and associated conditions.
The sections on conventional lab tests are purposefully brief. These tests are typically used to confirm a diagnosis. There are other more comprehensive sources of information on conventional medical lab testing.
Table of Contents
1. Gestational Diabetes
2. Miscarriage
3. Nausea And Vomiting Of Pregnancy
4. Postpartum Depression
5. Preeclampsia
6. Pregnancy-Associated Hypertension
7. Pregnancy (Prenatal)
8. Recurrent Pregnancy Loss
Chapter 1. Gestational Diabetes
Conventional Lab Tests
50-g, 1-hour glucose challenge test (GCT)
100-g, 3-hour oral glucose tolerance test (OGTT) (if GCT is abnormal)
Fasting glucose, hemoglobin A1C
BUN and creatinine
TSH and Free thyroxine
Spot urine protein-to-creatinine ratio
Additional Lab Tests
Insulin Resistance, Metabolic Syndrome
1254 Polish Caucasian women with GDM were recruited into the study. The HOMA-IR in the whole population ranged from 0.34 to 20.39. BMI, fasting insulin, fasting glucose and insulin dose per day increased along with increasing quartiles (HOMA-IR > 1.29). We observed a decrease of HOMA-B in the third quartile(1.92-2.89) compared with the first quartile(0.34-1.29). Insulin treatment was associated with HOMA-IR(<1.29 vs. >2.89), OR: 3.37, fasting glucose(<=6.11 vs. >6.11 mmol/dl), OR: 2.61, age (<=30 vs. >30 y. o.), OR: 1.54, and BMI(<25 vs. >=25 kg/m2), OR: 1.45. Maximum insulin dose was associated with HOMA-IR, OR: 2.00, after adjustment for family history of diabetes, and 2-h OGTT glucose. Insulin resistance assessed by the HOMA index at diagnosis is associated with the severity and pathophysiological heterogeneity of GDM. A HOMA-IR >1.29 points to the major role of insulin resistance, indicating the need for a treatment aimed at improving tissue sensitivity to insulin. A HOMA-IR 1.29-2.89 suggests reduced insulin secretion, which is an indication for the introduction of insulin therapy. A HOMA-IR >2.89 indicates insufficient compensation for insulin resistance, which suggests the need for a treatment aimed at improving susceptibility of tissues to insulin combined with insulin therapy. (Sokup et al., 2013)
A cross-sectional study was performed with 1,163 pregnant women with positive (1-hour plasma glucose >/= 7.2 mmol/L) in a 50-g oral glucose challenge test (OGCT). The 100-g oral glucose tolerance test (OGTT) was used to stratify the participants into three groups: NGT (n = 588), GIGT (n = 294), and GDM (n = 281). The GDM group had higher homeostasis model assessment of insulin resistance and lower insulin sensitivity index (ISOGTT), quantitative insulin sensitivity check index, homeostasis model assessment for estimation of index beta-cell secretion (HOMA-B), first and second phase insulin secretion, and insulin secretion-sensitivity index (ISSI) than the NGT group (p
C-Reactive Protein (CRP)
In a cohort of Hispanic women with recent gestational diabetes mellitus, oral glucose tolerance tests (OGTTs), intravenous glucose tolerance tests (IVGTTs), and bioelectrical impedance measurements were performed at 15-month intervals for up to 5 years, or until fasting plasma glucose exceeded 140 mg/dl (7.8 mmol/l). A total of 60 non-diabetic women had a median of four sets of OGTT + IVGTT during a median follow-up of 52 months. Fourteen of the women developed diabetes. None of the baseline characteristics were significantly predictive of a decline in DI. There were significant univariate associations between declining DI and weight gain (specifically fat gain), declining adiponectin and rising C-reactive protein. Multivariate analysis showed that the weight gain was the most significant factor associated with declining DI. The amount of association between weight gain and declining DI was explained 31% by changes in adiponectin and C-reactive protein and 40% by changes in insulin resistance. (Xiang et al., 2010)
A prospective nested case-control study in a pregnancy cohort measured first-trimester C-reactive protein (CRP) levels in 43 women who subsequently developed GDM and in a random sample of 94 women who remained euglycemic throughout pregnancy. First-trimester CRP levels were significantly increased among women who subsequently developed GDM compared with control subjects (3.1 vs. 2.1 mg/l, P < 0.01). The risk of developing GDM among women in the highest CRP tertile compared with the lowest tertile was 3.2 (95% CI 1.2-8.8). After adjusting for age, race/ethnicity, smoking, parity, blood pressure, and gestational age at CRP sampling, the risk of developing GDM among women in the highest compared with the lowest tertile was 3.6 (95% CI 1.2-11.4). When BMI was included in the model, however, the association between increased CRP and GDM was attenuated (odds ratio for the highest compared with lowest tertile 1.5 [95% CI 0.4-5.5]). In women who develop GDM, there is evidence of increased inflammation during the first trimester. This association is mediated in part by increased BMI. (Wolf et al., 2003)
A study examined the association between C-reactive protein (CRP) and GDM risk. Women were recruited before 16 weeks gestation and were followed until delivery. Maternal serum CRP was collected at 13 weeks' gestation, on average. Approximately 4.5% of the cohort (38 of 851) developed GDM. Elevated CRP was positively associated with GDM risk (P for trend = 0.007). After adjusting for maternal prepregnancy body mass index (BMI), family history of type 2 diabetes and nulliparity, women with CRP in the highest tertile experienced a 3.5-fold increased risk of GDM [95% CI 1.2, 9.8] as compared with those in the lowest tertile. The association between CRP and GDM was evident when analyses were restricted to lean women (BMI < 25 kg/m(2)). Lean women with CRP > or = 5.3 mg/L experienced a 3.7-fold increased risk of GDM [95% CI 1.6, 8.7] as compared with women with CRP < 5.3 mg/L. Systemic inflammation is associated with an increased risk of GDM, and the association is independent of maternal prepregnancy adiposity. (Qiu et al., 2004)
SHBG
A nested case-control study included women who participated in the Kaiser Permanente Northern California Multiphasic Health Check-up examination (1984-1996) and had a subsequent pregnancy (1984-2009). Eligible women were free of recognized diabetes. Case patients were 256 women in whom GDM developed. Two control subjects were selected for each case patient, and were matched for year of blood draw, age at examination, age at pregnancy, and number of intervening pregnancies. Compared with the highest quartile of SHBG concentrations, the odds of GDM increased with decreasing quartile (odds ratio 1.06 [95% CI 0.44-2.52]; 2.33 [1.07-5.09]; 4.06 [1.90-8.65]; P for trend < 0.001), after adjusting for family history of diabetes, pre-pregnancy BMI, race/ethnicity, alcohol use, pre-pregnancy weight changes, and homeostasis model assessment of insulin resistance. Having SHBG levels below the median (<64.5 nmol/L) and a BMI >/=25.0 kg/m2 was associated with fivefold increased odds of GDM compared with normal-weight women with SHBG levels at or above the median (5.34 [3.00-9.49]). Low pre-pregnancy SHBG concentrations were associated with increased risk of GDM and might be useful in identifying women at risk for GDM for early prevention strategies. (Hedderson et al., 2014)
A nested case-control study included 44 patients with gestational diabetes mellitus and 94 women with negative third-trimester screening for gestational diabetes mellitus. Compared with women without gestational diabetes mellitus, first-trimester sex hormone binding globulin levels were lower among women in whom gestational diabetes mellitus subsequently developed (187 +/- 82 nmol/L vs 233 +/- 92 nmol/L, P <.01). In logistic regression analysis that was adjusted for body mass index, age, race, smoking, blood pressure, serum testosterone and estradiol levels, and gestational age at serum collection, sex hormone binding globulin levels remained independently associated with subsequent gestational diabetes mellitus. For every 50-nmol/L increase in sex hormone binding globulin, the odds of gestational diabetes mellitus fell by 31% (odds ratio, 0.69; 95% CI: 0.48, 0.99). Sex hormone binding globulin offers a potential early marker to target women who are at risk for gestational diabetes mellitus. (Thadhani et al., 2003)
Comprehensive Thyroid Panel
There were 61 pregnant diabetic women in study group and 35 pregnant women in control group. About 36% of patients had GDM and 64% pre-gestational DM. Thyroid dysfunction was detected in 18% of study group compared with 8.6% of control group (P = 0.2). There was Thyroid dysfunction in 4.5% of GDM and 25.6% of pre-gestational DM (P = 0.045). There was no statistically significant difference between thyroid dysfunction in GDM group and control group (P=0.99).27% of GDM and 36% of pre-gestational DM and 23% of control group had positive titer of Anti TPO Ab without statistically significant differences among the three