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    Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series
    Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series
    Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series
    Ebook148 pages53 minutes

    Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series

    By Xiao-Feng Wu and Zechao Wang

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    About this ebook

    Transition Metal-Catalyzed Pyrimidine Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series provides an overview of pyrimidine, describing properties of these heterocycle compounds and the traditional synthetic procedures used for them. The book then explores catalyzed procedures for pyrimidine synthesis in greater detail and depth than is currently available in published review articles.

    This volume is part of the short series authored by Xiao-Feng Wu that summarizes recent achievements on heterocycle synthesis with transition metals as catalysts, with each volume dedicated to one heterocycle compound.

    • Offers a brief, focused review of the active research in pyrimidine synthesis via transition metal catalysis
    • Provides useful coverage of pyrimidine properties and both intermolecular and intramolecular cyclization
    • Volume Three in Elsevier’s short work series, Transition Metal-Catalyzed Heterocycles Synthesis
    • Provides greater detail and depth than is currently available in published review articles
    LanguageEnglish
    PublisherElsevier Science
    Release dateOct 21, 2016
    ISBN9780128093696
    Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis: Transition Metal-Catalyzed Heterocycle Synthesis Series
    Author

    Xiao-Feng Wu

    Xiao-Feng Wu was born in China in 1985. He studied chemistry in Zhejiang Sci-Tech University (China) where he got his bachelor’s degree in science (2007). In the same year, he went to Rennes 1 University (France) and earned his master’s degree in 2009. Then he joined Matthias Beller’s group in Leibniz-Institute for Catalysis (Germany) where he completed his PhD thesis in January 2012. Subsequently, he started his independent research at ZSTU and LIKAT. His research interests include carbonylation reactions, heterocycles synthesis, and the catalytic application of cheap metals. He also was a fellow of the Max-Buchner-Forschungsstiftung. On academic record, Xiao-Feng has authored more than 120 publications in international journals, and authored or edited five books, 15 chapters, and two patents.

    Read more from Xiao Feng Wu

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      Book preview

      Transition Metal Catalyzed Pyrimidine, Pyrazine, Pyridazine and Triazine Synthesis - Xiao-Feng Wu

      India

      Chapter 1

      Introduction

      Pyrimidine is a class of heterocyclic aromatic organic compounds, containing 2 nitrogen atoms at positions 1 and 3 of the 6-member ring. In nature, the pyrimidine ring is synthesized from glutamine, bicarbonate, and aspartate [1]. Pyrimidine as an integral part of DNA and RNA, demonstrates a diverse array of biological and pharmacological activities, including acting as an antitubercular, antimicrobial [2], antiplatelet [3], and antifungal agent [4], as well as having antiviral properties [5] (Scheme 1.1). Therefore, the synthesis of pyrimidines has become much more important. During the past years, various methodologies on pyrimidines synthesis have been developed quickly [6]. In this volume, the synthesis of pyrimidine will be elaborated.

      Scheme 1.1 Selected examples of bioactive pyrimidine derivatives.

      Other related six-member heterocyclic compounds such as pyrazine, pyridazine, and triazine will be discussed here as well. They are also highly significant in the investigation for new medicines, active pharmaceutical ingredients (API), and fine chemicals (Scheme 1.2) [7]. Their syntheses are attractive as well [8].

      Scheme 1.2 Selected examples of bioactive compounds.

      References

      1. Lagoja IM. Chem Biodiversity. 2005;2:1–50.

      2. Kamdar NR, Haveliwala DD, Mistry PT, Patel SK. Eur J Med Chem. 2010;45:5056–5063.

      3. Bruno O, Brullo C, Ranise A, et al. Bioorg Med Chem Lett. 2001;11:1397–1400.

      4. El-Hashash MA, Mahmoud MR, Madboli SA. Indian J Chem. 1993;32B:449–452.

      5. Shamroukh AH, Zaki MEA, Morsy EMH, Abdel-Motti FM, Abdel-Megeid FME. Arch Pharm. 2007;340:236–243.

      6a. a.Brown DJ. The Pyrimidines. In: New York: Wiley-Interscience; 1970;Weissberger A, ed. The Chemistry of Heterocyclic Compounds. Vol. 16.

      6b. b.Lister JH. Fused Pyrimidines, Part II, The Purines. In: New York: Wiley-Interscience; 1971;Weissberger A, Taylor EC, eds. The Chemistry of Heterocyclic Compounds. Vol. 24.

      6c. c.Hurst DT. An Introduction to the Chemistry and Biochemistry of Pyrimidines, Purines and Pteridines Chichester: Wiley;

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