Everand Logo

Welcome to Everand!

  • Discover millions of ebooks, audiobooks, and so much more with a free trial

    Only $11.99/month after trial. Cancel anytime.

    Unavailable
    Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity
    Unavailable
    Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity
    Unavailable
    Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity
    Ebook585 pages5 hours

    Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity

    By Xiaolong Chen, Yuele Lu, Yongxian Fan and Yinchu Shen

    ()

    Currently unavailable

    Currently unavailable

    About this ebook

    Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.

    Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production.

    Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored.

    Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications.

    • Offers complete coverage of validamycin chemistry from a highly experienced team of authors
    • Encourages the discovery of further novel drugs based on validamycin derivatives
    • Presents an interesting model for establishing new pharmaceutical leads from agricultural sources
    • Includes coverage of the total chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine and validoxylamines
    LanguageEnglish
    PublisherElsevier Science
    Release dateMar 31, 2017
    ISBN9780081011133
    Unavailable
    Validamycin and Its Derivatives: Discovery, Chemical Synthesis, and Biological Activity
    Author

    Xiaolong Chen

    Professor Chen and his team have decades of experience working with Validamycin. Their research originally spanned its initial discovery, development and production as an agricultural antibiotic, and is now focussed on exploring its recent adaptation to a pharmaceutical lead with a multitude of potential applications. The group have published numerous papers on their work, including an important review on the preparation of Validamycin derivative Valienamine in 2003, followed by another key review on the preparation of Voglibose in 2006. In addition, they hold a number of patents relating to the degradation of Validamycin to produce Valienamine.

    Related authors

    Related to Validamycin and Its Derivatives

    Related ebooks

    Chemistry For You

    View More
    View More

    Related podcast episodes

    Related articles

    • Article

      Root Propagation and Powdery Mildew

      Mar 10, 2023

      What are the effects of antimicrobial solutions on cannabis cultivation and production? The cannabis industry is growing at an explosive rate and the regulations governing the cultivation, processing, and distribution are rapidly evolving. They’re al

      4 min read

    • Article

      Opinion: Companies Must Responsibly Manufacture The Antimicrobials Society Needs

      Jan 30, 2020

      Providing access to antibiotics and other antimicrobials while reducing resistance to these medicines presents a dual manufacturing challenge: ensuring a cost-effective supply while minimizing their emission into the environment.

      4 min read

    • Article

      Opinion: Bringing Order To The ‘Wild Frontier’ Of Microbiome Medicine

      Oct 2, 2018

      When it comes to #microbiome medicine, @US_FDA and @NIH need to create a solid, science-based regulatory framework to help realize the promise of living drugs.

      4 min read

    • Article

      Playing Chicken

      Apr 24, 2016

      Playing Chicken
      17 min read

    • Article

      Phytochemicals

      Oct 21, 2020

      Phytochemicals
      1 min read

    • Article

      New Antibiotic Found In Potato Bacteria

      Nov 9, 2022

      An international research team has discovered a new antibiotic in potatoes. Dubbed solanimycin, the discovery suggests that plant-based microorganisms might represent a rich source of antibiotics to which bacteria are not yet resistant. Antibiotic me

      1 min read

    • Article

      Antibiotic From Pathogenic Bacterium In Potatoes

      Oct 28, 2022

      The discovery of a new antibiotic that acts against a wide range of fungi known to infect and wreak havoc on agricultural crops has been reported in mBio, a journal published by the American Society for Microbiology in association with the American A

      1 min read

    • Article

      Rebelling Against Resistance

      Sep 13, 2023

      Rebelling Against Resistance
      12 min read

    • Article

      A Look At Alternative Food Sources

      May 6, 2022

      “The global population is expected to reach 9,7 billion in 2050. To meet the increasing demand for food, overall food production will need to be raised by about 70% above 2009 levels. New food sources imply those that have not been widely consumed, e

      4 min read

    • Article

      Healing Post-pandemic Eczema

      Sep 28, 2022

      Healing Post-pandemic Eczema
      13 min read

    • Article

      Accident Leads To Basis For New Antibiotics To Kill Resistant Bacteria

      Feb 22, 2024

      Researchers have developed molecules for a new class of antibiotics that can overcome drug resistant bacteria. About a decade ago, researchers in University of California, Santa Barbara chemistry professor Guillermo Bazan’s lab began to observe a rec

      5 min read

    • Article

      Use Biofilm’s Own Enzymes to Defeat Its ‘Armor’

      Jun 23, 2017

      Researchers have developed a way to use the same enzymes that help microbes create biofilms to keep biofilms from forming and even destroy them. Biofilms are slimy, glue-like membranes that microbes, like bacteria and fungi, make in order to colonize

      3 min read

    Related categories

    Reviews for Validamycin and Its Derivatives

    0 ratings

    0 ratings0 reviews

    What did you think?

    Tap to rate

    Review must be at least 10 words