Role of Materials Science in Food Bioengineering
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The Role of Materials Science in Food Bioengineering, Volume 19 in the Handbook of Food Bioengineering, presents an up-to-date review of the most recent advances in materials science, further demonstrating its broad applications in the food industry and bioengineering. Many types of materials are described, with their impact in food design discussed. The book provides insights into a range of new possibilities for the use of materials and new technologies in the field of food bioengineering. This is an essential reference on bioengineering that is not only ideal for researchers, scientists and food manufacturers, but also for students and educators.
- Discusses the role of material science in the discovery and design of new food materials
- Reviews the medical and socioeconomic impact of recently developed materials in food bioengineering
- Includes encapsulation, coacervation techniques, emulsion techniques and more
- Identifies applications of new materials for food safety, food packaging and consumption
- Explores bioactive compounds, polyphenols, food hydrocolloids, nanostructures and other materials in food bioengineering
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Role of Materials Science in Food Bioengineering - Alexandru Mihai Grumezescu
Role of Materials Science in Food Bioengineering
Handbook of Food Bioengineering, Volume 19
Edited by
Alexandru Mihai Grumezescu
Alina Maria Holban
Table of Contents
Cover
Title page
Copyright
List of Contributors
Foreword
Series Preface
Preface for Volume 19: Role of Materials Science in Food Bioengineering
Chapter 1: New Trends in Food Technology for Green Recovery of Bioactive Compounds From Plant Materials
Abstract
1. Introduction
2. The Review of Extraction Methods of Bioactive Compounds
3. Conclusions
Chapter 2: Different Bioengineering Approaches on Production of Bioflavor Compounds
Abstract
1. Introduction
2. Biotechnological Processes for the Production of Bioflavor and Fragrance Compounds
3. Bioengineering Approaches Used for the Production of Bioflavor Compounds: Current State and Prospects
4. Conclusions
Chapter 3: Biocompatibility and Toxicity of Allotropic Forms of Carbon in Food Packaging
Abstract
1. Introduction
2. The Structure of Allotropic Forms of Carbon
3. Others Forms of Graphite
4. Biocompatibility and Toxicity of Nanocrystalline Diamond Coatings
5. Biocompatibility and Bioactivity of Allotropic Forms of Carbon
6. Toxicity of Carbon Nanomaterials in Food Nanopackaging
7. Functionalization of Nanodiamonds by Plasma-Chemical and Chemical Methods for Use on the Food Bioactive Packaging
8. Nanotechnology in Food Packaging
9. Conclusions
Chapter 4: Fabrication of Functional Electrospun Nanostructures for Food Applications
Abstract
1. Introduction
2. Encapsulation and Immobilization of Functional Food Additives
3. Blending of Polymers
4. Scaffolding Materials
5. Characterization of Electrospun Nanofibers
6. Functionalization of Polymer Nanofibers
7. Nanofiber Applications in Food
8. Conclusions
Chapter 5: Bioactive Peptides as Functional Food Ingredients
Abstract
1. Introduction
2. Different Technologies for the Production of Bioactive Peptides
3. Bioactive Peptides: Mechanism of Action and Applications
4. Absortion, Bioavailability, and Effectiveness of Bioactive Peptides: Strategies to Enhance Them
5. Bioactive Peptides in Food Systems
6. Safety of Bioactive Peptide: Regulatory Standards
7. Conclusions
Chapter 6: Potential Applications of Cyclodextrin Inclusion Complexes, Liposomes, and Drug-in-Cyclodextrin-in-Liposome in Food Industry and Packaging
Abstract
Abbreviations
1. Introduction
2. Applications of Free Natural Molecules in Food
3. Encapsulation Systems
4. Characterization of Carrier Systems Loading Natural Molecules
5. Biological Effects
6. Food Applications
7. Conclusions
Chapter 7: Coacervation Technique as an Encapsulation and Delivery Tool for Hydrophobic Biofunctional Compounds
Abstract
1. Introduction
2. Selection of Shell and Core Materials
3. Microencapsulation Process Using Complex Coacervation Technique
4. Biotechnological Applications
5. Characterization of Final Microcapsule Products
6. Conclusion and Future Trends
Chapter 8: Food Hydrocolloids as Matrices for Edible Packaging Applications
Abstract
1. Introduction
2. Polysaccharides and Proteins: Matrices for Edible Films and Coatings
3. Properties of Edible Films and Coatings Based on Hydrocolloids
4. Improvement of Hydrocolloid-Based Matrices Properties
5. Functionalization of Polysaccharide- and Protein-Based Materials
6. Application of Edible Films and Coatings Based on Hydrocolloids
7. Conclusions
Chapter 9: Probiotic and Synbiotic Yogurt Production Using Free or Alginate/Resistant Starch Microencapsulated Lactobacillus plantarum
Abstract
1. Introduction
2. Experimental Practice
3. Results and Discussion
4. Conclusions
Acknowledgment
Chapter 10: Nutraceutical Formulation Strategies to Enhance the Bioavailability and Efficiency: An Overview
Abstract
1. Introduction
2. Strategies to Increase Bioavailability in Nutraceutical Delivery Systems
3. Nutraceutical Delivery Systems
4. Conclusions
Chapter 11: Health Perspectives of an Isoflavonoid Genistein and its Quantification in Economically Important Plants
Abstract
1. Introduction
2. Source and Distribution
3. Biosynthesis of Genistein
4. Bioavailability and Metabolism of Genistein
5. Biological Properties and Mechanisms of Genistein
6. Actions of Genistein at the Cellular Level
7. Prophylaxis and Therapy
8. Genistein Engineering and Quantification in Transgenic Plants
9. Conclusions
Chapter 12: Microbial Polyamino Acids: An Overview for Commercial Attention
Abstract
1. Introduction
2. Types of Polyamino Acids
3. Biosynthesis of Polyamino Acids
4. Production of Polyamino Acids
5. Biodegradation of Polyamino Acids
6. Purification and Characterization
7. Applications of Polyamides
8. Outlook and Perspectives
Chapter 13: Promising Functional Lipids for Therapeutic Applications
Abstract
1. Introduction
2. Therapeutic Roles of Natural Functional Lipids
3. Molecular Considerations of Functional Lipids
4. Conclusions
Chapter 14: Status and Future Prospects of Fructooligosaccharides as Nutraceuticals
Abstract
1. Introduction
2. Genesis of Nutraceuticals
3. History and Importance of Nutraceuticals
4. Nutraceutical Regulations
5. Nutraceutical Market at a Glance
6. Functional Foods
7. Prebiotics and Their Role in Nutrition
8. Fructans and Their Classification
9. Sources of Fructans
10. Inulin
11. Overview of Fructooligosaccharides
12. Methods of FOS Production
13. β-Fructofuranosidases
14. Fructosyltransferases
15. Mechanism of Action
16. Microbial Production of FOS
17. Improvement in FOS Yields
18. Fermentation Strategies
19. Immobilization Strategies
20. Purification
21. Downstream Processing
22. Applications of Fructooligosaccharides
23. Concluding Remarks
Chapter 15: Food Materials Science in Egg Powder Industry
Abstract
1. Eggs
2. Egg Powder
3. Conclusion
Index
Copyright
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List of Contributors
Muhammad Abdullah, University of Veterinary and Animal Sciences, Lahore, Pakistan
Mauricio O. Adaro
National University of San Luis, San Luis, Argentina
National Council of Scientific and Technical Research (CCT-San Luis-CONICET), Institute of Applied Physics (INFAP), San Luis, Argentina
Dominic Agyei
Centre for Chemistry and Biotechnology, Deakin University, Geelong, VIC, Australia
University of Otago, Dunedin, New Zealand
Taiwo O. Akanbi, Centre for Chemistry and Biotechnology, Deakin University, Geelong, VIC, Australia
Ali Asghar, National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan
Lorena Atarés, Institute of Food Engineering for Development, Polytechnic University of Valencia, Valencia, Spain
Sandip B. Bankar, Aalto University School of Chemical Engineering, Aalto, Espoo, Finland
Sonia E. Barberis
National University of San Luis, San Luis, Argentina
National Council of Scientific and Technical Research (CCT-San Luis-CONICET), Institute of Applied Physics (INFAP), San Luis, Argentina
Colin J. Barrow, Centre for Chemistry and Biotechnology, Deakin University, Geelong, VIC, Australia
Grisel Bersi
National University of San Luis, San Luis, Argentina
National Council of Scientific and Technical Research (CCT-San Luis-CONICET), Institute of Applied Physics (INFAP), San Luis, Argentina
Mladen Brnčić, University of Zagreb, Zagreb, Croatia
Amrita Chakraborty, Centre for Research in Nanoscience & Nanotechnology, University of Calcutta, Kolkata, West Bengal, India
Catherine Charcosset, University Claude Bernard Lyon 1, CPE Lyon, Villeurbanne, France
Prakash V. Chavan, Bharati Vidyapeeth University, Pune, Maharashtra, India
Amparo Chiralt, Institute of Food Engineering for Development, Polytechnic University of Valencia, Valencia, Spain
Tanmoy K. Dey, Centre for Research in Nanoscience & Nanotechnology, University of Calcutta, Kolkata, West Bengal, India
Pubali Dhar, Centre for Research in Nanoscience & Nanotechnology, University of Calcutta, Kolkata, West Bengal, India
Sophie Fourmentin, Université de Littoral Côte d’Opale, Dunkerque, France
Hélène Greige-Gerges, Lebanese University, Beirut, Lebanon
Onur Guneser, Usak University, Usak, Turkey
Brendan J. Holland, Centre for Chemistry and Biotechnology, Deakin University, Geelong, VIC, Australia
Muge I. Hosoglu, Canakkale Onsekiz Mart University, Canakkale, Turkey
Muhammad A. Irshad, National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan
Komal Javed, University of Agriculture, Faisalabad, Pakistan
Alberto Jiménez, Institute of Food Engineering for Development, Polytechnic University of Valencia, Valencia, Spain
Chityal Ganesh Kumar, CSIR—Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Ashwini Malla
Bharathiar University, Coimbatore, Tamil Nadu
Kasturba Gandhi Degree and PG College for Women, Secunderabad, Telangana, India
Muhammad M. Masood, National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan
Katarzyna A. Mitura, Koszalin University of Technology, Koszalin, Poland
Yun P. Neo
University of Auckland, Auckland, New Zealand
Taylor’s University, Kuala Lumpur, Malaysia
Pranhita R. Nimbalkar, Bharati Vidyapeeth University, Pune, Maharashtra, India
Anabella L. Origone
National University of San Luis, San Luis, Argentina
National Council of Scientific and Technical Research (CCT-San Luis-CONICET), Institute of Applied Physics (INFAP), San Luis, Argentina
Debjyoti Paul, Centre for Research in Nanoscience & Nanotechnology, University of Calcutta, Kolkata, West Bengal, India
Conrad O. Perera, University of Auckland, Auckland, New Zealand
Yedla Poornachandra, CSIR—Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Sathishkumar Ramalingam, Bharathiar University, Coimbatore, Tamil Nadu, India
Muhammad A. Randhawa, National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan
Sudip Ray, University of Auckland, Auckland, New Zealand
Raquel Requena, Institute of Food Engineering for Development, Polytechnic University of Valencia, Valencia, Spain
Suzana Rimac-Brnčić, University of Zagreb, Zagreb, Croatia
Makkia Saleem, University of Agriculture, Faisalabad, Pakistan
Carine Sebaaly, Lebanese University, Beirut, Lebanon
Yahya Shafiei, Islamic Azad University, Khoy, Iran
Mian K. Sharif, University of Agriculture, Faisalabad, Pakistan
Rekha S. Singhal, Institute of Chemical Technology, Mumbai, Maharashtra, India
Sarada Sripada, CSIR—Indian Institute of Chemical Technology, Hyderabad, Telangana, India
María Vargas, Institute of Food Engineering for Development, Polytechnic University of Valencia, Valencia, Spain
Sandra Voća, University of Zagreb, Zagreb, Croatia
Bo Wang, Nu-Mega Ingredients Pty Ltd, Brisbane, QLD, Australia
Yonca K. Yuceer, Canakkale Onsekiz Mart University, Canakkale, Turkey
Paweł K. Zarzycki, Koszalin University of Technology, Koszalin, Poland
Jana Š. Žlabur, University of Zagreb, Zagreb, Croatia
Foreword
In the last 50 years an increasing number of modified and alternative foods have been developed using various tools of science, engineering, and biotechnology. The result is that today most of the available commercial food is somehow modified and improved, and made to look better, taste different, and be commercially attractive. These food products have entered in the domestic first and then the international markets, currently representing a great industry in most countries. Sometimes these products are considered as life-supporting alternatives, neither good nor bad, and sometimes they are just seen as luxury foods. In the context of a permanently growing population, changing climate, and strong anthropological influence, food resources became limited in large parts of the Earth. Obtaining a better and more resistant crop quickly and with improved nutritional value would represent the Holy Grail for the food industry. However, such a crop could pose negative effects on the environment and consumer health, as most of the current approaches involve the use of powerful and broad-spectrum pesticides, genetic engineered plants and animals, or bioelements with unknown and difficult-to-predict effects. Numerous questions have emerged with the introduction of engineered foods, many of them pertaining to their safe use for human consumption and ecosystems, long-term expectations, benefits, challenges associated with their use, and most important, their economic impact.
The progress made in the food industry by the development of applicative engineering and biotechnologies is impressive and many of the advances are oriented to solve the world food crisis in a constantly increasing population: from genetic engineering to improved preservatives and advanced materials for innovative food quality control and packaging. In the present era, innovative technologies and state-of-the-art research progress has allowed the development of a new and rapidly changing food industry, able to bottom-up all known and accepted facts in the traditional food management. The huge amount of available information, many times is difficult to validate, and the variety of approaches, which could seem overwhelming and lead to misunderstandings, is yet a valuable resource of manipulation for the population as a whole.
The series entitled Handbook of Food Bioengineering brings together a comprehensive collection of volumes to reveal the most current progress and perspectives in the field of food engineering. The editors have selected the most interesting and intriguing topics, and have dissected them in 20 thematic volumes, allowing readers to find the description of basic processes and also the up-to-date innovations in the field. Although the series is mainly dedicated to the engineering, research, and biotechnological sectors, a wide audience could benefit from this impressive and updated information on the food industry. This is because of the overall style of the book, outstanding authors of the chapters, numerous illustrations, images, and well-structured chapters, which are easy to understand. Nonetheless, the most novel approaches and technologies could be of a great relevance for researchers and engineers working in the field of bioengineering.
Current approaches, regulations, safety issues, and the perspective of innovative applications are highlighted and thoroughly dissected in this series. This work comes as a useful tool to understand where we are and where we are heading to in the food industry, while being amazed by the great variety of approaches and innovations, which constantly changes the idea of the food of the future.
Anton Ficai PhD (Eng)
Department Science and Engineering of Oxide Materials and Nanomaterials,
Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest,
Bucharest, Romania
Series Preface
The food sector represents one of the most important industries in terms of extent, investment, and diversity. In a permanently changing society, dietary needs and preferences are widely variable. Along with offering a great technological support for innovative and appreciated products, the current food industry should also cover the basic needs of an ever-increasing population. In this context, engineering, research, and technology have been combined to offer sustainable solutions in the food industry for a healthy and satisfied population.
Massive progress is constantly being made in this dynamic field, but most of the recent information remains poorly revealed to the large population. This series emerged out of our need, and that of many others, to bring together the most relevant and innovative available approaches in the intriguing field of food bioengineering. In this work we present relevant aspects in a pertinent and easy-to-understand sequence, beginning with the basic aspects of food production and concluding with the most novel technologies and approaches for processing, preservation, and packaging. Hot topics, such as genetically modified foods, food additives, and foodborne diseases, are thoroughly dissected in dedicated volumes, which reveal the newest trends, current products, and applicable regulations.
While health and well-being are key drivers of the food industry, market forces strive for innovation throughout the complete food chain, including raw material/ingredient sourcing, food processing, quality control of finished products, and packaging. Scientists and industry stakeholders have already identified potential uses of new and highly investigated concepts, such as nanotechnology, in virtually every segment of the food industry, from agriculture (i.e., pesticide production and processing, fertilizer or vaccine delivery, animal and plant pathogen detection, and targeted genetic engineering) to food production and processing (i.e., encapsulation of flavor or odor enhancers, food textural or quality improvement, and new gelation- or viscosity-enhancing agents), food packaging (i.e., pathogen, physicochemical, and mechanical agents sensors; anticounterfeiting devices; UV protection; and the design of stronger, more impermeable polymer films), and nutrient supplements (i.e., nutraceuticals, higher stability and bioavailability of food bioactives, etc.).
The series entitled Handbook of Food Bioengineering comprises 20 thematic volumes; each volume presenting focused information on a particular topic discussed in 15 chapters each. The volumes and approached topics of this multivolume series are:
Volume 1: Food Biosynthesis
Volume 2: Food Bioconversion
Volume 3: Soft Chemistry and Food Fermentation
Volume 4: Ingredients Extraction by Physicochemical Methods in Food
Volume 5: Microbial Production of Food Ingredients and Additives
Volume 6: Genetically Engineered Foods
Volume 7: Natural and Artificial Flavoring Agents and Food Dyes
Volume 8: Therapeutic Foods
Volume 9: Food Packaging and Preservation
Volume 10: Microbial Contamination and Food Degradation
Volume 11: Diet, Microbiome and Health
Volume 12: Impact of Nanoscience in the Food Industry
Volume 13: Food Quality: Balancing Health and Disease
Volume 14: Advances in Biotechnology for Food Industry
Volume 15: Foodborne Diseases
Volume 16: Food Control and Biosecurity
Volume 17: Alternative and Replacement Foods
Volume 18: Food Processing for Increased Quality and Consumption
Volume 19: Role of Materials Science in Food Bioengineering
Volume 20: Biopolymers for Food Design
The series begins with a volume on Food Biosynthesis, which reveals the concept of food production through biological processes and also the main bioelements that could be involved in food production and processing. The second volume, Food Bioconversion, highlights aspects related to food modification in a biological manner. A key aspect of this volume is represented by waste bioconversion as a supportive approach in the current waste crisis and massive pollution of the planet Earth. In the third volume, Soft Chemistry and Food Fermentation, we aim to discuss several aspects regarding not only to the varieties and impacts of fermentative processes, but also the range of chemical processes that mimic some biological processes in the context of the current and future biofood industry. Volume 4, Ingredients Extraction by Physicochemical Methods in Food, brings the readers into the world of ingredients and the methods that can be applied for their extraction and purification. Both traditional and most of the modern techniques can be found in dedicated chapters of this volume. On the other hand, in volume 5, Microbial Production of Food Ingredients and Additives, biological methods of ingredient production, emphasizing microbial processes, are revealed and discussed. In volume 6, Genetically Engineered Foods, the delicate subject of genetically engineered plants and animals to develop modified foods is thoroughly dissected. Further, in volume 7, Natural and Artificial Flavoring Agents and Food Dyes, another hot topic in food industry—flavoring and dyes—is scientifically commented and valuable examples of natural and artificial compounds are generously offered. Volume 8, Therapeutic Foods, reveals the most utilized and investigated foods with therapeutic values. Moreover, basic and future approaches for traditional and alternative medicine, utilizing medicinal foods, are presented here. In volume 9, Food Packaging and Preservation, the most recent, innovative, and interesting technologies and advances in food packaging, novel preservatives, and preservation methods are presented. On the other hand, important aspects in the field of Microbial Contamination and Food Degradation are shown in volume 10. Highly debated topics in modern society: Diet, Microbiome and Health are significantly discussed in volume 11. Volume 12 highlights the Impact of Nanoscience in the Food Industry, presenting the most recent advances in the field of applicative nanotechnology with great impacts on the food industry. Additionally, volume 13 entitled Food Quality: Balancing Health and Disease reveals the current knowledge and concerns regarding the influence of food quality on the overall health of population and potential food-related diseases. In volume 14, Advances in Biotechnology for Food Industry, up-to-date information regarding the progress of biotechnology in the construction of the future food industry is revealed. Improved technologies, new concepts, and perspectives are highlighted in this work. The topic of Foodborne Diseases is also well documented within this series in volume 15. Moreover, Food Control and Biosecurity aspects, as well as current regulations and food safety concerns are discussed in the volume 16. In volume 17, Alternative and Replacement Foods, another broad-interest concept is reviewed. The use and research of traditional food alternatives currently gain increasing terrain and this quick emerging trend has a significant impact on the food industry. Another related hot topic, Food Processing for Increased Quality and Consumption, is considered in volume 18. The final two volumes rely on the massive progress made in material science and the great applicative impacts of this progress on the food industry. Volume 19, Role of Materials Science in Food Bioengineering, offers a perspective and a scientific introduction in the science of engineered materials, with important applications in food research and technology. Finally, in volume 20, Biopolymers for Food Design, we discuss the advantages and challenges related to the development of improved and smart biopolymers for the food industry.
All 20 volumes of this comprehensive collection were carefully composed not only to offer basic knowledge for facilitating understanding of nonspecialist readers, but also to offer valuable information regarding the newest trends and advances in food engineering, which is useful for researchers and specialized readers. Each volume could be treated individually as a useful source of knowledge for a particular topic in the extensive field of food engineering or as a dedicated and explicit part of the whole series.
This series is primarily dedicated to scientists, academicians, engineers, industrial representatives, innovative technology representatives, medical doctors, and also to any nonspecialist reader willing to learn about the recent innovations and future perspectives in the dynamic field of food bioengineering.
Alexandru M. Grumezescu
Politehnica University of Bucharest, Bucharest, Romania
Alina M. Holban
University of Bucharest, Bucharest, Romania
Preface for Volume 19: Role of Materials Science in Food Bioengineering
Bioengineering represents an emerging domain of food industry. In recent years, materials science has greatly impacted the food industry by the development of improved (bio)materials with important applications in food design, processing, and storage. Engineered materials are utilized to obtain functional foods, encapsulate valuable compounds and ingredients, detect contaminants, and also ensure an appropriate packaging and preservation of food products. Engineered foods may exhibit significantly higher quality or completely new properties, and therefore new bioengineering tools are highly investigated. In this volume we bring together the most recent knowledge regarding the progress and applications of materials science in food bioengineering. Engineering tools, main considered aspects, and safety concerns regarding the current and future applications of materials science in food industry are also discussed.
The volume contains 15 chapters prepared by outstanding authors from Croatia, Turkey, Poland, New Zealand, Malaysia, Argentina, Lebanon, France, Australia, Spain, Iran, Pakistan, India, and Finland.
The selected manuscripts are clearly illustrated and contain accessible information for a wide audience, especially food scientists, engineers, biotechnologists, biochemists, and industrial companies and also for any reader interested in learning more about the role of materials science in food bioengineering.
Chapter 1, entitled New Trends in Food Technology for Green Recovery of Bioactive Compounds From Plant Materials, prepared by Žlabur et al., discusses recent tools applied for synthesis and characterization of materials and their applications in food industry for the recovery of bioactive compounds. The basic principles of the application of a pulsed electric field (PEF), ultrasound (US), microwave assisted extraction (MAE), supercritical fluid extraction (SFE), enzyme assisted extraction, and pressurized liquid extraction (PLE) are described here.
In Chapter 2, Different Bioengineering Approaches on Production of Bioflavor Compounds, Hosoglu et al. review the current state of the art of bioprocess used for the production of flavor and fragrance compounds, with emphasis on different ways used to improve process productivity. Bioengineering provides promising technical options for increasing the efficiency of bioflavor production, such as different fermentation strategies (batch-fed-batch and continuous fermentation); gas-phase or two-phase reactions; specific reactor constructions, such as membrane, solid state, or closed loop reactors; optimization and modeling approaches of bioprocess; and in situ recovery of product.
In Chapter 3, Biocompatibility and Toxicity of Allotropic Forms of Carbon in Food Packaging, Mitura and Zarzycki discuss the practical aspects, biocompatibility, and toxicity of allotropic forms of carbon in food packaging, empathizing the antimicrobial effects of carbon nanostructures.
Chapter 4, Fabrication of Functional Electrospun Nanostructures for Food Applications, written by Neo et al., reviews the latest developments in the manufacture of electrospun nanofibers for food applications using various electrospinning techniques. Using novel nanotechnology methods, sensor devices can be coupled with electrospun fibers as effective screening devices to detect bacteria and other microorganisms and to discriminate antioxidants and other useful components.
In Chapter 5, Bioactive Peptides as Functional Food Ingredients, Barberis et al. describe the useful roles of bioactive peptides and tools to improve their nutraceutical impact by reducing limitations, such as low bioavailability due to the gastrointestinal digestion, poor transportability through the membranes, and rapid plasma clearance.
Chapter 6, Potential Applications of Cyclodextrin Inclusion Complexes, Liposomes, and Drug-in-Cyclodextrin-in-Liposome in Food Industry and Packaging, prepared by Sebaaly et al., provides a detailed up-to-date summary of the emerging usage of cyclodextrins, liposomes, and combined drug-in-cyclodextrin-in-liposome systems in the food industry. The preparation methods at small and large scale are presented. The physicochemical characteristics of the nanostructure encapsulating agents are considered. The chapter also deals with the systems stability and analyzes the effectiveness of encapsulated molecules in food products.
In Chapter 7, Coacervation Technique as an Encapsulation and Delivery Tool for Hydrophobic Biofunctional Compounds, Wang et al. focus on the utilization of coacervation techniques for encapsulating and stabilizing various oxidative unstable biofunctional food ingredients. Discussion is centered upon factors affecting the entire preparation of microencapsulation products, from the design of the delivery system, selection of the appropriate shell
material, to the crosslinking of the encapsulant. Characterization of the final microcapsules and applications of coacervation technology in the food industry is also discussed.
In Chapter 8, Food Hydrocolloids as Matrices for Edible Packaging Applications, Jiménez et al., review the most recent advances in edible packaging applications of food hydrocolloids, taking into account both polysaccharide and protein-based materials. The production techniques, the different strategies to improve functional properties, and the most recent applications of these materials are dissected in a comprehensive way.
Chapter 9, Probiotic and Synbiotic Yogurt Production Using Free or Alginate/Resistant Starch Microencapsulated Lactobacillus plantarum, written by Shafiei, explains the production procedure of probiotic and symbiotic yogurt containing free or alginate/resistant starch-encapsulated Lactobacillus plantarum. Additionally, the emulsion technique of microencapsulation and its effect on survival of L. plantarum during the storage period is also described.
In Chapter 10, Nutraceutical Formulation Strategies to Enhance the Bioavailability and Efficiency: An Overview, Asghar et al. compare recent literature for a number of popular delivery systems among the scientific and nutritionist community, and on the basis of different data and studies available in journals, select and discuss the best available delivery system for nutraceuticals.
Chapter 11, Health Perspectives of an Isoflavonoid Genistein and its Quantification in Economically Important Plants, by Malla and Ramalingam, explains the multidirectional action of genistein in living cells, making it a potent drug. This precious isoflavonoid has also been quantified in other nonleguminous plants to increase the nutritional sources for natural dietary consumption.
In Chapter 12, Microbial Polyamino Acids: An Overview for Commercial Attention, Bankar et al. cover a wide range of discussion on the importance of polyamino acids, including structure, biosynthesis, and biodegradation of naturally occurring ε-PL, γ-PGA, and cyanophycin. Fermentation and biosynthetic pathway study, along with downstream processing, and characterization of these polyamino acids are detailed extensively in this chapter. In addition, associated large-scale production and challenges are also discussed. Multifarious applications of polyamino acids in the food, as well as pharmaceutical industries have been summarized comprehensively. Finally, various challenges and future opportunities in well-designed trials that are needed to improve the current knowledge of polyamino acids are conjectured.
In Chapter 13, Promising Functional Lipids for Therapeutic Applications, Paul et al. highlight the multidomain progress in lipid research to counter major health challenges, such as diabetes, cardiovascular diseases, arthritis, impaired cognition, and neurological diseases. In particular, the therapeutic role of eicosapentaenoic acid, docosahexaenoic acid, conjugated linoleic acid, conjugated linolenic acid, γ-linolenic acid, pinoleinic acid, phytosterols, marine phospholipids, marine carotenoids, and a large class of enzymatically synthesized diacylglycerol, phenolipids, and structured phospholipids are discussed.
Chapter 14, Status and Future Prospects of Fructooligosaccharides as Nutraceuticals, written by Kumar et al., describes different fermentation methods employed for the production of fructooligosaccharides (FOS) and various analytical techniques used for separation and structural elucidation. In addition, the functional properties and the application of FOS in a variety of food formulations and their implications in nutrition and health are delineated.
In Chapter 15, Food Materials Science in Egg Powder Industry, Sharif et al. give an overview of egg composition; bioactive components; types of edible eggs; preparation of egg powder; the nutritional and functional properties; impact of various processing technologies, such as pan drying, foam drying, freeze drying, oven drying, and spray-drying on its functional, and nutritional properties; and food applications.
Alexandru M. Grumezescu
Politehnica University of Bucharest, Bucharest, Romania
Alina M. Holban
University of Bucharest, Bucharest, Romania
Chapter 1
New Trends in Food Technology for Green Recovery of Bioactive Compounds From Plant Materials
Jana Š. Žlabur
Sandra Voća
Mladen Brnčić
Suzana Rimac-Brnčić University of Zagreb, Zagreb, Croatia
Abstract
Plant material extracts show numerous benefits for human health—namely, chemical compounds that show the beneficial effects on human health are integral parts of the plants, often included in their defense system, defined like biologically active components. In the biologically active components, the following compounds are included: polyphenols, vitamins, and various pigments that are high in antioxidant activity, which is mainly reflected by suppression of free radicals and thereby inhibition of the oxidation processes in the tissue cells. Various industrial branches have shown significant interest in the application of plant bioactive compounds, such as the pharmaceutical industry for drugs production and the food industry for the production of food supplements classified as a super foods.
Extraction techniques of bioactive components from plants as a main goal assumes higher yields of the isolated compounds coupled with shortening of the extraction time. Conventional extraction techniques are still most often used despite the fact that they show a number of limitations: the use of organic solvents, energy-inefficient, longer extraction periods, relatively low yields, and the degradation effect on nutrients. Lately, modern extraction techniques of biologically active compounds based on the fundamental principles of the green chemistry are being developed with accented environmentally friendly and energy efficient characteristics. In this chapter, the basic principles of the application of a pulsed electric field (PEF), ultrasound (US), microwave-assisted extraction (MAE), supercritical fluid extraction (SFE), enzyme-assisted extraction, and pressurized liquid extraction (PLE) have been described.
Keywords
bioactive compounds
pulsed electric field
ultrasound
microwave
enzyme-assisted extraction
pressurized liquid extraction
1. Introduction
The policy of functional food concept first appeared in Japan in 1992 by establishing the Foods of Specific Health Uses.
In the following years, the concept of using food for promoting health was developed in Europe by project Functional Food Science in Europe.
The main results and conclusions of the mentioned project was the definition of the term functional food, which was defined as a food which is demonstrated to positively affect one or more physiological functions, so that it is able to increase the well-being and/or to reduce the risk to suffer a disease
(Diplock et al., 1999).
The main goal of the functional food concept is preventing the occurrence of various diseases such as cardiovascular diseases, obesity, diabetes, cancer, and other chronic diseases characteristic of modern lifestyle. The chemical compounds related to the functional food concept are various biologically active compounds with significant antioxidant activity. The producers of functional food mentioned bioactive compounds to promote the traditional food by increasing its nutritional quality. Nowadays, the market offers different products from the functional food category, which may contain various bioactive compounds from vitamins, polyphenolic compounds, carotenoids, dietary fibers, minerals, and so forth (Nutrition Society, 1999).
1.1. Biologically Active Compounds
Biologically active compounds, often called bioactive compounds, are, by consensus, defined as: essential and nonessential compounds (e.g., vitamins or polyphenols) that occur in nature, are part of the food chain, and can be shown to have an effect on human health
(Biesalski et al., 2009). Such chemical compounds in the literature are often classified as phytochemicals (Tiwari et al., 2013). Phytochemicals are part of various plant materials from fruits, vegetables, herbs, and so forth, and they are often classified into the following groups: polyphenols, carotenoids, glucosinolates, dietary fibers, alkaloids, and so forth (Tiwari et al., 2013). It is important to emphasize that the phenolic compounds are contained in all plant organs (secondary plant metabolits), and thus widely used in various food categories intended for everyday consumption, such as fresh fruits, vegetables, grains, olives, beans, chocolate and so forth, but also in food products such as tea, wine, coffee, beer, and others (Shahidi and Naczk, 2004). The role of bioactive compounds in biosystems like human cells is that they are possessors of antioxidant activity. Respectively, antioxidant compounds are inhibitors of the oxidation processes due to their ability to neutralize free radicals (Devasagayam et al., 2004). Antioxidant activity of the plant species is directly correlated with the content of vitamins and various phenolic phytochemicals such as flavonoids, glycosides, alkaloids, and others (Šic Žlabur et al., 2016; Zayova et al., 2013). Chemical compounds that exhibit the most powerful antioxidant effects are polyphenolic compounds, particularly phenols and flavonoids. Therefore, the mentioned compounds are widely used for commercial purposes as nutritional supplements in food products (Chu et al., 2000). In the human body phenol compounds exhibit their positive effect through several mechanisms: (1) removal of free radicals (antioxidant effect); (2) protection and regeneration of other antioxidants (e.g., vitamin E); and (3) chelating properties of the oxidizing metal ions (bind themselves to metal ions and thus inhibit its absorption and utilization; Buyukokuroglu et al., 2001; Garcia-Salas et al., 2010). Antioxidant activity of the phenolic compounds primarily depends on the number of hydroxyl groups (—OH), on their position in the molecule, but also on the type of substitution on the aromatic ring. Specifically, bond energy between a hydrogen atom and an oxygen atom in the hydroxyl group attached to the aromatic ring in the phenol molecule is less than in aliphatic compounds (alkanes, aldehydes, aliphatic alcohols, and fats), respectively; such phenol compounds more easily donate (release) a hydrogen atom that binds on the free radical (unpaired electron) (Rice-Evans et al., 1996).
2. The Review of Extraction Methods of Bioactive Compounds
The extraction of bioactive compounds is defined as a separation and isolation process of matter with an appropriate solvent from a solid or liquid mixture, in which the individual substance is made soluble or has a better solubility than the other ingredients of a mixture. Due to the aggregate state of the two phases in a mixture, we distinguish two types of extraction methods: liquid–liquid and solid–liquid (solid phase; Gertenbach, 2001). The principle of extraction is based on the occurrence of molecular diffusion, which is characterized by equalizing the concentrations of dissolved substances between systems in a mixture that come into mutual contact. The amount of diffused substance (per unit area and time) is directly proportional to the diffusion coefficient and the difference between the concentrations in the boundary layer, and inversely proportional to the diffusion distance, with respect to particle size. In general, the diffusivity of the liquid phase is approximately inversely proportional to the diameter of the particles. Increasing the temperature of the system increases the diffusivity significantly, but also the temperature increase strongly affects the decrease of the solution viscosity (Cacace and Mazza, 2003). In liquid–liquid extraction, the transition occurs between the two liquid phases that do not interfere with each other. After separating the two solvent layers, the concentration ratio of the solvent is constant and the mixture is at equilibrium. In liquid–liquid extraction, at the interface of the two solvents mass transfer between the two liquid phases occurs and their surfaces increase to increase the efficiency and speed of the extraction procedure. Increasing the area of two solvents is achieved by agitation of two liquid phases (Grandison and Lewis, 1996; Rydberg, 2004). In solid–liquid extraction, the substance is isolated from the solid phase in liquid—that is, the solvent. The organic molecules can be encapsulated within a solid phase or be linked with intermolecular forces, and the release of these molecules from the solid phase is achieved by the penetration of solvent in the vicinity of the molecules. In the described extraction method, the solvent penetration into a solid phase can be significantly increased by grinding the solid phase (Gertenbach, 2001; Hennion, 1999; Simpson, 2000).
The traditional extraction techniques for the isolation of bioactive compounds from plant materials use different methods but, from a scientific point of view, the extraction method is not yet fully defined (Rao et al., 2012). The extraction using a solvent (organic and inorganic) is one of the most used techniques in the preparation of extracts from plant material due to the simplicity in application, a relatively high efficiency, and a wide range of application. The yield of each compound during the solvent extraction primarily depends on the type of solvents different polarity, the extraction time, temperature of the system, a ratio of the sample, and the solvent in the extraction process as well as on the chemical and physical properties of the sample intended for extraction (Dai and Mumper, 2010). The classical (conventional) extraction methods of chemical compounds essentially are based on the proper solvent choice, usually an alcoholic solution, and other organic solvents such as acetone and hexane, using high temperature and agitation (Vinatoru, 2001). Described techniques require a significantly longer extraction time, higher amounts of the sample, and an organic solvent, which, among other things, considerably increase the expense of the entire process. It should be noted that the use of organic solvents has a negative impact on the environment and on human health (Ramos et al., 2002); however, modern food-processing techniques and their use significantly reduce or decrease their impact. The main disadvantage of organic solvent use as an extraction source is that the final extract often requires further concentration and purification before use, especially for products intended for human consumption. Organic solvents are extremely efficient in the extraction of various compounds, but also are undesirable in the final product, especially when it comes to alcoholic solutions and other solvents, which show extremely harmful effects on human health. Recently, less frequent use of organic solvents alone and replacement of them with organic solvents with water have become increasingly popular. A higher proportion of water in the organic phase is very effective for extraction of bioactive compounds from dry plant material (Abou-Arab et al., 2010; Bimakr et al., 2011; Xu and Chang, 2007). The ultimate goal of environmentally and health-friendly chemical processes is the complete replacement of organic solvents with water (Mustafa and Turner, 2011). From the conventional methods of bioactive compound extraction from plant materials, the following techniques are commonly used: maceration, Soxhlet extraction, and hydrodistillation. Soxhlet extraction is primarily intended for the isolation of lipids, but nowadays the use of Soxhlet technique in isolation of different bioactive compounds from natural sources is known. The isolation of bioactive compounds by Soxhlet method is carried out in Soxhlet extractor. During Soxhlet extraction the suitable solvent evaporates, condenses, and then passes through the homogenized and ground solid sample located in the extraction thimble. After that, the solvent returns to the flask together with the extract. The fundamental shortcomings of the Soxhlet extraction are the long duration of process (10–24 h), environmental pollution due to the high consumption of organic solvent (300 mL/sample), and the fact that the compounds that are extracted must be stable at the boiling point of the extraction solvent. Due to the large volume of extract that is equal to the initial solvent volume, it must be concentrated mostly by evaporation (Azmir et al., 2013; Dean et al., 2002).
Minimal-processing food techniques as a main goal assumes significant preservation of the nutritional food components with emphasis on significant antioxidant activity of bioactive compounds. In the daily diet, the emphasis is on functional food, which, besides the energy value, has significant nutritional value, contains a significant amount of components that show a beneficial effect on human health. Bioactive compounds (such as polyphenols) are extremely thermo labile—at high temperatures their structure modifies and their primary significance decreases, so classical extraction techniques of mentioned compounds are inadequate in the application. The most common extraction principles of phenolic compounds are based on the appropriate selection of aqueous solutions of organic solvents that contribute to the separation and dissolution of phenolic compounds of different chemical structures from the plant cells (liquid–liquid extraction) (Dobiáš et al., 2010). From the organic solvents used during the application of liquid–liquid extraction of the phenolic compounds, the most often are ethanol, acetone, methanol, and their aqueous solutions (v/v) (Robards, 2003; Ross et al., 2009). It is important to emphasize that it is very difficult to choose the optimal extraction technique for all the phenolic compounds present in some plant species due to their different chemical structures (Naczk and Shahidi, 2006). Also, the interaction of phenolic compounds with other molecules in plant cell such as carbohydrates and proteins is very common and results in formation of complexes that are insoluble in organic solvent (Khoddami et al., 2013). The liquid-liquid extraction of phenolic compounds shows numerous disadvantages from the use of organic solvents to the application of high temperatures and prolonged extraction periods. Therefore, extraction techniques are used that are more selective, quicker, do not affect the degradation of nutrients, and are environmentally friendly (Liazid et al., 2007; Mahugo et al., 2009).
2.1. New Extraction Techniques of Bioactive Compounds
Modern extraction techniques such as microwave-assisted extraction, supercritical extraction, pressure-assisted extraction, and ultrasound-assisted extraction are applicable for the extraction of compounds of different chemical structures and those that are characterized by noninvasive temperatures and reduced or complete reduction of the various organic solvents use (e.g., alcohol; Puri et al., 2012). Therefore, they are suitable for the extraction of bioactive compounds such as polyphenols (Dai and Mumper, 2010; Garcia-Salas et al., 2010; Huang et al., 2010; Ignat et al., 2011; Shao et al., 2014). Phenolic compounds exhibit a high degree of degradation in terms of technological processes, and show distinct thermolability, sensitivity to light, the impact of pathogens, mechanical damage of the plant cells tissues, and so forth. During conventional food processing, it is very difficult to preserve them (Biesaga and Pyrzynska, 2013). For the aforementioned reasons, minimal food-processing techniques that are directed toward the use of noninvasive heating processes, during which lower temperatures are involved that ultimately will not result in reducing the phenolic compounds of raw material (Vinatoru, 2001).
2.1.1. Microwave-assisted extraction
The use of microwaves for food processing and also for the application of extraction of various bioactive compounds from different food and plant matrices is constantly developing. Microwave heating process belongs to the group of thermal treatments of minimal food processing and is characterized by numerous advantages: less start-up time, faster heating, and high energy efficiency, which results in shortening the application time, precise process control, selective heating, and the most importantly, significantly preserving the nutritional quality of raw materials. Except for extraction, microwave heating is applicable in different food industry processes such as: cooking, baking, drying, thawing, pasteurization, sterilization, roasting, blanching, etc. (Sumnu et al., 2005).
The main mechanism in microwave-assisted extraction is use of microwave energy. Microwaves are electromagnetic fields in the frequency range from 300 MHz to 300 GHz.In plant matrices, microwaves directly interact with different molecules and heat is generated (Fig. 1.1). The plant material is bombarded with electromagnetic radiation in the microwave range (300 MHz to 300 GHz), which causes rapid rotation of the polarized molecules (e.g., water) leading to the accelerated movement of molecules (vibration), creating friction and heat generation (Ohlsson and Bengtsson, 2002). In general, the mechanism of microwave heating can be classified into two major categories: dipolar rotation and ionic conduction. Dielectric constant is the most important characteristic of solvents and plant materials in the application of microwaves. Solvents with lower dielectric constant absorb less microwave energy (Camel, 2000; Eskilsson and Bjorklund, 2000). For example, water contains permanent dipoles that, under an alternating field, tend to reorient resulting in orientation polarization (Metaxas and Meredith, 1983) and heat generation. Dielectric properties of plant materials depend on chemical composition, temperature, and frequency (Calay et al., 1995). In ionic conduction, all charged particles of plant matrices under microwave frequency will be accelerated in one direction and then in the opposite, resulting collision with nearby particles. The particles are set into more agitated motion and heat is generated (Buffler, 1993).
Figure 1.1 Conduction Heating in the Conventional and Microwave-Assisted Extraction.
Microwave-assisted extraction shows a number of advantages compared to conventional extraction methods. The extraction of bioactive compounds assisted by microwaves assumes the possibility of using different types of solvents, polar and nonpolar, extraction time is significantly reduced, and recovery of the analyte is significantly higher compared to conventional methods of isolation (Ondruschka and Asghari, 2006). To optimize the microwave extraction process of phytonutrients, it is important to combine the following parameters: temperature, pressure, extraction time, microwave power, type and solvent volume, and the water amount in the material (Camel, 2000; Eskilsson and Bjorklund, 2000). The microwave extraction method is applicable to a wide range of plant materials and assumes possibility of bioactive compounds extraction without degradation effect. The biologically active compounds such as vitamins, phenols, and especially anthocyanins exhibit a significant thermolability, and noninvasive extraction methods, such as microwave-assisted extraction do not show a significant temperature increase in system during application (Koubaa et al., 2015). One of the most important advantages of microwave-assisted extraction is the possibility of isolation of bioactive compounds without solvent use, solvent-free extraction. Solvent-free microwave extraction (SFME) is a combination of microwave heating and dry distillation, performed at atmospheric pressure without added solvent or water. The SFME method provides easy application and operation principle that involves placing plant material in a microwave reactor without adding any solvent. Under microwave energy the water molecules from the plant cells starts to rotate, the heat is generated, which distends the plant cells and leads to rupture of the plant cell structure (Lucchesi et al., 2004).
Numerous authors have studied the application of microwaves for extraction of bioactive compounds from different plant materials. Thus, many scientific papers are related to the extraction of essential oils and volatile and nonvolatile compounds from aromatic herbs (Dai et al., 2010; Hao et al., 2002; Incorvia Mattina et al., 1997; Pan et al., 2000; 2002; Shu et al., 2003). Besides essential oils and volatile compounds, bioactive compounds such as total phenols also show a possibility for extraction by microwaves (Table 1.1). Gallo et al. (2010) reported a significant result of antioxidant activity of spice extracts obtained by microwave-assisted extraction, which suggests a high content of extracted bioactive compounds (secondary plant metabolites) such as polyphenols (Table 1.2).
Table 1.1
Source: from Gallo, M., Ferracane, R., Graziani, G., Ritieni, A., Fogliano, V., 2010. Microwave assisted extraction of phenolic compounds from four different spices. Molecules 15, 6365–6374.
Table 1.2
Source: from Gallo, M., Ferracane, R., Graziani, G., Ritieni, A., Fogliano, V., 2010. Microwave assisted extraction of phenolic compounds from four different spices. Molecules 15, 6365–6374.
Lucchesi et al. (2004) studied the solvent-free microwave extraction of essential oils and volatile compounds from the following aromatic herbs: basil (Ocimum basilicum L.), garden mint (Mentha crispa L.), and thyme (Thymus vulgaris L.). Solvent-free microwave extraction of the essential oils from the mentioned aromatic herbs lasted for 30 min. The essential oil yield and the aroma profile were similar with those obtained by conventional hydro-distillation, which lasted 4.5 h. It can be concluded that solvent-free microwave extraction results in higher amounts of extracted essential oils and more valuable oxygenated compounds, and extraction time is significantly reduced, which suggest a substantial savings in terms of energy, plant material, and time. Also, in another study, Lucchesi et al. (2007) reported a high result of essential oils extracted by solvent-free microwave extraction from cardamom seed (Elletaria cardamomum L.) compared with those obtained by the traditional hydro-distillation. In that study, the three main variables of solvent-free microwave extraction had a positive influence on the yield of oil, extraction time, power, and moisture content. Microwave-assisted extraction was successfully implemented in the process of lipids (fats and oils) extraction from olives (Virot et al., 2007). In the mentioned study, the microwave technique was implemented in the Soxhlet extraction—microwave-integrated Soxhlet (MIS) extraction. The group of authors reported that extraction of oils by MIS lasted for 32 min and were quantitatively (yield) and qualitatively (fatty acid composition) similar to those obtained by conventional Soxhlet extraction, which lasted 8 h. From the mentioned research, we can conclude that microwave-integrated Soxhlet extraction is a good alternative for the extraction of fat and oils from food products. Except for essential oils and fats, the microwave technique was successfully implemented for extraction of glycosides—precisely, the steviol glycosides characteristic metabolites from Stevia rebaudiana Bertoni leaves. Alupului et al. (2009), Jaitak et al. (2009), and Alupului and Lavric (2012) reported many advantages in using microwave-assisted extraction including increased extraction yields, high steviol glycoside recovery, and economic benefits (relatively low-cost methods), in comparison to conventional methods. In their study, Kaufmann and Christen (2002) show examples of microwave-assisted extraction of numerous chemical compounds from different plant materials and the main advantages of microwave application. Table 1.3 shows the chemical compounds and plant matrices as an example for the possibility of microwave-assisted extraction application.
Table 1.3
Source: from Kaufmann, B., Christen, P., 2002. Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction. Phytochem. Anal. 13, 105–113.
2.1.2. Ultrasound-assisted extraction
Recently, in food-processing technology innovative techniques that are based on the foundations of minimal food processing are increasingly popular, with the main aim of preserving nutritionally valuable components of food (especially bioactive compounds), which show a beneficial effect on human health. One of the minimal processing techniques is an ultrasound of high intensity that shows a wide application (Fig. 1.2) in the technological processes of the food industry and biotechnology (Brnč=ić et al., 2009).
Figure 1.2 The Application of High-Intensity Ultrasound in the Food Technology and Biotechnology.
Ultrasound is defined as sound-wave frequency of 20 kHz and more and is characterized by several parameters: the amplitude (A), frequency (f), wavelength (λ), and attenuation coefficient (α) (Brondum et al., 1998; Butz and Tauscher, 2002; McClements, 1995). The transition of ultrasonic wave through a medium varies sinusoidally with time, whereas amplitude decreases with increasing distance from the source of ultrasound primarily due to attenuation. The main causes of attenuation are adsorption and dispersion. The adsorption is caused by the physical mechanism, which converts ultrasonic energy into heat, whereas dispersion usually occurs in emulsions, suspensions, and foams (Karlović et al., 2014).
In general, ultrasound of low and high intensity differs in the ultrasonic spectrum, which fundamentally varies in the amount of energy generated by the sound field (Fellows, 2000; Karlović et al., 2014; McClements, 1995). Ultrasound of low intensity implies a lower intensity of 1 W/cm² and higher frequencies from 2 MHz (Dujmić et al., 2013; Table 1.4). Due to low levels of power, ultrasonic waves of low intensity do not cause physical and chemical changes in the properties of the material through which the wave passes, so the low-intensity ultrasound is used as an analytical method (Knorr et al., 2004) and in medicine as diagnostic ultrasound. Ultrasound of high intensity implies intensities higher than 1 W/cm² (usually in the range 10–1000 W/cm²) and frequencies in the range 18–100 kHz (Table 1.4). Because waves of high power and low frequencies (20–100 kHz) occur, their use in the processes of food technology and biotechnology is recommended (Bosiljkov et al., 2010; Brnč=ić et al., 2010; Knorr et al., 2004).
Table 1.4
The main ultrasonic mechanism is cavitation. Cavitation is defined as the process of forming gas bubbles in a liquid medium by the effect of an ultrasonic field. By passing sound wave (longitudinal) through a liquid medium, areas of alternating pressure and expansion swirl occurs. Due to the effects of expansion swirls in a solution, the negative pressure develops, and when the incurred pressure is low enough to overcome the intramolecular forces, air bubbles are formed. During each subsequent expansion, pressure compression and swirl-creation incurred bubbles expand and contract. Due to the application of low-intensity ultrasound, low power levels of ultrasound (less than 1 W/cm²) of stable cavitation occur. Stable cavitation causes the formation of bubbles in the liquid, but their size during the formation of alternating pressure swirls oscillates only slightly, and the diameters of the bubbles are minimally changed (Suslick et al., 2011). During the processing of materials with high-intensity ultrasound, when a sound wave appears in liquid medium, longitudinal waves occur, whereby a cycle of alternating compression and expansion are formed (Bosiljkov et al., 2009; Brnč=ić et al., 2010; Jelič=ić et al., 2012; Sala et al., 1995). Alternating pressure exchanges (pressure fluctuations) causes cavitation to form the gas bubbles in the material (Patist and Bates, 2008). Bubble size increases during each cycle, until they reach a critical size in which ultrasound energy is not sufficient to maintain the gas phase in the bubble and the bubbles implode. The molecules around the bubbles vigorously collide with each other resulting in so-called microareas in which very high temperatures (above 5000°C) and pressures (from 50 MPa to 100 MPa) develop (Knorr et al., 2004). The extremely high temperature and pressure incurred by the implosion (rupture) of bubbles can lead to dissociation of water vapor in the OH− radicals and H+ ions (Butz and Tauscher, 2002). The formed radicals are extremely reactive and are considered to be responsible for the inactivation of bacteria cells by the oxidation process (Chemat et al., 2011). The oxidation processes causes damage of microbiological structures prior to inactivation. However, the formed defects are not sufficient for a lethal effect on the microorganism cell, so the recover of cell structures damaged by oxidation are possible. Also, recent studies have proved that the heat released during the implosion of bubbles is not the main lethal mechanism of ultrasound due to the fact that the released heat is extremely localized and quickly vanishes. The shock waves of pressure that develops during the implosion of bubbles are considered a major mechanism of microorganism inactivation (Ferrario et al., 2015). The described phenomenon is known as a transient cavitation (Fig. 1.3), the main lethal mechanism of ultrasound (Sala et al., 1995). The ability of ultrasound to cause cavitation depends on the characteristics of the ultrasound (frequency, intensity), the product properties (viscosity, density, and surface tension) and environmental conditions (temperature, pressure, and humidity) (Brnč=ić et al., 2009; Dolatowski et al., 2007).
Figure 1.3 Cavitation Principle in Application of High Intensity Ultrasound.
The four parameters that affect cavitation and bubble collapse are (1) solvent properties, most applications of ultrasonic treatment are performed in water (polar liquid), but also other less polar liquids (some organics) can be also used (Santos et al., 2009). The optimal properties of the solvent are high vapor pressure, low viscosity, and low surface tension. (2) External pressure, with increasing external pressure the vapor pressure of liquid decreases, to induce cavitation the higher intensity is necessary. For a specific frequency there is a particular external pressure that will provide an optimum sonochemical reaction. (3) Higher external temperature reduces the intensity necessary to induce cavitation. (4) The frequency of the sound wave: at high sonic frequencies (MHz) the production of cavitation bubbles becomes more difficult than at low sonic frequencies (kHz). As the sonic frequency increases to achieve cavitation, the intensity of the applied sound must be increased. Lower frequency produces more violent cavitation, with a consequence of higher localized temperatures and pressures (Santos et al., 2009). The effect of ultrasound in food processing depends on the number of bubbles (number of bubbles increases with increasing ultrasonic amplitude) but also on the intensity of the bubbles, which depends on the ratio of the maximum and the initial bubble size. The mentioned ratio is closely related to the ultrasonic power. Among important factors during the ultrasonic treatment, hydrostatic pressure and temperature should be also mentioned, but their effect is somewhat ambiguous with regard to whether they can participate in the increase and reduction of the bubble number but also in the increase and decrease of the implosion intensity (Ashokkumar, 2011; Kuijpers et al., 2002). Cavitation in a liquid medium can cause a full degassing, initiate various chemical reactions by creating free radicals, accelerate chemical reactions by enhancing the mixing of the reactants, stimulate polymerization and depolymerization by breaking the chemical bonds, increase the emulsification level, increase the diffusion rate, and assist in the extraction of substances and removal of various microorganisms (Chemat et al., 2011).
Besides cavitation, it is important to mention the other effect of ultrasound during its application in food. This is primarily a medium heating that occurs as a result of the strong collision of molecules around the bubbles and the development of microareas
with extremely high temperatures and pressures. Due to the formation of microareas
the selective temperature increase in the media occurs, but because of the relatively small volume of heated fluid formed, hot spots quickly vanish. Hot spots can cause the destruction of microorganisms, but the biggest drawback is that they are localized and operate on a relatively small area of the treated media (Piyasena et al., 2003).
The basic components of each device intended for ultrasonic treatment include the power generator and the inverter that convert electrical energy into mechanical vibrations. The power generator primarily converts a standard AC frequency, which is typically in the range of 50–60 Hz required for the formation of ultrasonic waves in converters. The basic function of the inverter is the conversion of electrical or mechanical energy into sound energy. There are two basic types of inverters: magnetostrictive and piezoelectric, usually piezoelectric inverter is used in the application. Nowadays, several hundred different ultrasound systems are applicable in use, especially in the food industry. Ultrasonic systems fundamentally differ according to the type of inverter and on the model of ultrasonic application in the process. In the ultrasonic food-processing systems, two major types of ultrasonic equipment are of the greatest importance: the ultrasonic bath and the system with ultrasonic probe. The ultrasonic bath (Fig. 1.4) consists of a main tank containing the process medium and the inverter, which, in most ultrasonic bath constructions, is attached to the bottom of the bath. Most ultrasonic bath systems operate at a frequency of 2–100 kHz and the main disadvantage is relatively low ultrasonic power (Mason, 1998).
Figure 1.4 The Schematic Representation of the Ultrasonic Bath.
Ultrasonic systems of high power can be designed as a probe system in which one or more metal probes is attached to the inverter with the main purpose