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    Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia
    Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia
    Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia
    Ebook286 pages3 hours

    Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia

    By Ahmed Al-Harrasi, Hidayat Hussain, René Csuk and Husain Yar Khan

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    About this ebook

    Exhibiting a wealth of interesting activities and novel structures, Boswellic acid and the other terpenoids of the genus Boswellia (from which frankincense is derived) are a growing source of interest for the natural product drug discovery community. Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia presents, in a single volume for the first time, key research into their structures, synthesis and potential as starting points for the development of medicinal agents.

    Drawing on the authors’ expert knowledge, this volume is an interesting insight into the identification of novel compounds from endemic plant sources, and is a useful tool for all researchers involved in the discovery and development of bioactive structures from natural products.

    • Collates key information on the underlying chemistry and activities of bioactive agents from the Boswellia species
    • Highlights techniques applicable to the study of natural products across the globe
    • Provides insights into the assessment of medicinal natural products with high economic potential
    LanguageEnglish
    PublisherElsevier Science
    Release dateSep 19, 2018
    ISBN9780081024485
    Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia
    Author

    Ahmed Al-Harrasi

    Prof. Ahmed Al-Harrasi received his BSc in Chemistry from Sultan Qaboos University in Oman in 1997. Then he moved to the Free University of Berlin from which he obtained his MSc in Chemistry in 2002 and then his PhD in Organic Chemistry in 2005 as a DAAD-fellow under the supervision of Prof. Hans-Ulrich Reissig. His PhD work was on New Transformations of Enantiopure 1,2-oxazines. He then received the Fulbright award in 2008 for postdoctoral research in chemistry, for which he joined Prof. Tadhg Begely at Cornell University to work on the synthesis of isotopically-labeled thiamin pyrophosphate. After a postdoctoral research stay at Cornell University in 2009, he started his independent research at the University of Nizwa in Oman, where he founded the chair of Oman’s Medicinal Plants and Marine Natural Products, merging chemistry and biological research. Dr. Al-Harrasi is currently a professor of organic chemistry and the Vice Chancellor for Graduate Studies, Research and External Relations at the University of Nizwa. He was a chair and invited speaker in many international conferences, and is a reviewer for more than 15 international chemistry and biotechnology journals. He has authored and co-authored over 290 scientific papers and six book chapters, and taught many chemistry courses both at MSc and BSc levels.

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      Book preview

      Chemistry and Bioactivity of Boswellic Acids and Other Terpenoids of the Genus Boswellia - Ahmed Al-Harrasi

      2017.

      Chapter 1

      Taxonomy of Boswellia Tree, Traditional Medicinal Uses of Frankincense and Historical Aspects of Boswellic Acids

      Ahmed Al-Harrasi¹, Hidayat Hussain¹, Rene Csuk² and Husain Y. Khan¹,    ¹UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, Nizwa, Oman,    ²Martin-Luther Universität Halle-Wittenberg, Organische Chemie, Halle, Germany

      Abstract

      The genus Boswellia belongs to the Burseraceae family, with approximately 700 species originating from 18 genera. The genus Boswellia, with 21 species, has its principal center of endemism in eastern Africa (Sudan, Eritrea, Ethiopia, Somalia, and Kenya), southern Arabia (Oman and Yemen), and India. Boswellic acid contents vary remarkably from one species to another. They are reported in significantly large amounts in Boswellia sacra, Boswellia serrata, Boswellia carterii, and Boswellia papyrifera. Parts of the Boswellia tree, in particular the resins, have been used in the traditional medicines of Arabia, India, Africa, and China for millennia. Interestingly, most of these traditional uses are strongly supported by recent findings. The known antiinflammatory activity of frankincense is likely due to Boswellic acids, as supported by several recent reports. Boswellic acids have received remarkable attention due to their potential therapeutic power. Since 1892, when Alexander Tschirch and Oscar Halbey performed the first extraction of the frankincense resin to separate it into neutral and basic fractions, this interest has continued to

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