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    Osler’s Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Osler’s Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Osler’s Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Ebook106 pages58 minutes

    Osler’s Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

    By Kenneth Kee

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    About this ebook

    This book describes Osler’s Disease, Diagnosis and Treatment and Related Diseases
    Osler disease is an inherited blood vessel disease that produces bleeding from the mucous membranes of the nose, gastrointestinal tract, lungs or urinary tract.
    Patients may also have abnormal blood vessels that bleed in the brain.
    Osler Disease or Osler-Weber-Rendu syndrome (OWR) is also called hereditary hemorrhagic telangiectasia (HHT).
    It is a genetic blood vessel disorder that often causes excessive bleeding.
    It was first thought to be a bleeding disease but this disorder is caused by problems with the blood vessels themselves.
    People with OWR may have missing capillaries in some of their blood vessels.
    These abnormal blood vessels are termed arteriovenous malformations (AVM).
    Because there is nothing to reduce the pressure of the blood before it moves into the veins, people with OWR often have strained veins that may ultimately rupture.
    When large AVMs arise, hemorrhages can happen.
    Hemorrhages in these locations can become life-threatening:
    1. The brain
    2. The lungs
    3. The liver
    4. The gastrointestinal tract
    People with OWR also have abnormal blood vessels termed “telangiectasias” near the skin and mucosal surfaces.
    These blood vessels are swollen or widened and are often seen as small red dots on the skin surface.
    The disorder can be found throughout the world.
    The syndrome involves about one in 5,000 people.
    Many people with the disorder do not know they have it, so this number may really be higher.
    There is no gender difference.
    People with OWR have an abnormal gene that causes their blood vessels to form imperfectly.
    OWR is an autosomal dominant genetic disease.
    This means that only one parent requires having the abnormal gene to pass it on to their children.
    OWR does not pass over a generation.
    The signs and symptoms may differ greatly between family members.
    If the patient has OWR, it is possible that the child could have a milder or more serious course.
    In very rare cases, a child can be born with OWR even when none of the parents has the syndrome.
    This occurs when one of the genes that cause OWR forms mutation in an egg or sperm cell.
    Symptoms
    Symptoms of OWR and their severity differ widely, even among family members.
    A frequent sign of OWR is a large red birthmark, occasionally called a port wine stain.
    A port-wine stain is produced by a collection of dilated blood vessels, and it may become darker in color as the person grows older.
    Telangiectasias (small dilated blood vessels) are another frequent symptom of OWR.
    They are often small red dots and are susceptible to bleeding.
    The marks may be observed in young children or not until after puberty.
    Telangiectasias can emerge on the:
    1. Face
    2. Lips
    3. Tongue
    4. Ears
    5. Fingertips
    6. Whites of the eyes
    7. Gastrointestinal system
    AVMs can happen anywhere inside the body.
    The most frequent sites are:
    1. The nose
    2. The lungs
    3. The gastrointestinal tract
    4. The liver
    5. The brain
    6. The spine
    The most frequent symptom of OWR is nosebleeds produced by telangiectasias in the nose.
    In fact, this is often the first symptom of OWR.
    Nosebleeds may occur daily or as rarely as twice per year.
    When AVMs develop in the lungs, they can involve lung function.
    A person with a lung AVM may have shortness of breath.
    Diagnosis:
    Blood test can examine for anemia, or iron deficiency in the blood.
    CT scan can reveal internal AVMs, such as in the lungs, liver, and brain
    Treatment:
    Treatment is to stop bleeding and replace blood loss
    Iron supplements
    Transfusion
    Estrogen
    Aminocaproic acid
    Electrocautery and argon beam ablation
    Laser cautery
    Embolization of blood vessel
    Surgery

    TABLE OF CONTENT
    Introduction
    Chapter 1

    LanguageEnglish
    PublisherKenneth Kee
    Release dateApr 25, 2019
    ISBN9780463418048
    Osler’s Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions
    Author

    Kenneth Kee

    Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

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      Book preview

      Osler’s Disease, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions - Kenneth Kee

      Osler’s Disease,

      A

      Simple

      Guide

      To

      The Condition,

      Diagnosis,

      Treatment

      And

      Related Conditions

      By

      Dr Kenneth Kee

      M.B.,B.S. (Singapore)

      Ph.D (Healthcare Administration)

      Copyright Kenneth Kee 2019 Smashwords Edition

      Published by Kenneth Kee at Smashwords.com

      Dedication

      This book is dedicated

      To my wife Dorothy

      And my children

      Carolyn, Grace

      And Kelvin

      This book describes Osler’s Disease, Diagnosis and Treatment and Related Diseases which is seen in some of my patients in my Family Clinic.

      (What You Need to Treat Osler’s Disease)

      This eBook is licensed for your personal enjoyment only. This eBook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each reader.

      If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy.

      Thank you for respecting the hard work of this author.

      Introduction

      I have been writing medical articles for my blog: http://kennethkee.blogspot.com (A Simple Guide to Medical Disorder) for the benefit of my patients since 2007.

      My purpose in writing these simple guides was for the health education of my patients.

      Health Education was also my dissertation for my Ph.D (Healthcare Administration).

      I then wrote an autobiolographical account of his journey as a medical student to family doctor on his other blog: http://afamilydoctorstale.blogspot.com.

      This autobiolographical account A Family Doctor’s Tale was combined with my early A Simple Guide to Medical Disorders into a new Wordpress Blog A Family Doctor’s Tale on http://kenkee481.wordpress.com.

      From which many free articles from the blog was taken and put together into 800 eBooks.

      Some people have complained that the simple guides are too simple.

      For their information they are made simple in order to educate the patients.

      The later books go into more details of medical disorders.

      The first chapter is always from my earlier blogs which unfortunately tends to have typos and spelling mistakes.

      Since 2013, I have tried to improve my spelling and writing.

      As I tried to bring the patient the latest information about a disorder or illness by reading the latest journals both online and offline, I find that I am learning more and improving on my own medical knowledge in diagnosis and treatment for my patients.

      Just by writing all these simple guides I find that I have learned a lot from your reviews (good or bad), criticism and advice.

      I am sorry for the repetitions in these simple guides as the second chapters onwards have new information as compared to my first chapter taken from my blog.

      I also find repetition definitely help me and maybe some readers to remember the facts in the books more easily.

      I apologize if these repetitions are irritating to some readers.

      Chapter 1

      Osler disease

      What is Osler disease?

      Osler disease is an inherited blood vessel disease that produces bleeding from the mucous membranes of the nose, gastrointestinal tract, lungs or urinary tract.

      Patients may also have abnormal blood vessels that bleed in the brain.

      Osler Disease or Osler-Weber-Rendu syndrome (OWR) is also called hereditary hemorrhagic telangiectasia (HHT).

      It is a genetic blood vessel disorder that often causes excessive bleeding.

      It was first thought to be a bleeding disease but this disorder is caused by problems with the blood vessels themselves.

      In a healthy circulatory system, there are 3 forms of blood vessels.

      There are arteries, capillaries, and veins.

      1. Blood moving away from the heart is transported through arteries, which moves at a high pressure.

      2. Blood moving towards the heart is transported through veins, and it moves at a lower pressure.

      3. The capillaries are sited between these two types of blood vessels, and the narrow passageway of the capillaries helps to decrease the pressure of the blood before it reaches the veins.

      People with OWR may have missing capillaries in some of their blood vessels.

      These abnormal blood vessels are termed arteriovenous malformations (AVM).

      Because there is nothing to reduce the pressure of the blood before it moves into the veins, people with OWR often have strained veins that may ultimately rupture.

      When large AVMs arise, hemorrhages can happen.

      Hemorrhages in these locations can become life-threatening:

      1. The brain

      2. The lungs

      3. The liver

      4. The gastrointestinal tract

      People with OWR also have abnormal blood vessels termed telangiectasias near the skin and mucosal surfaces.

      These blood vessels are swollen or widened and are often seen as small red

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