In today's VETgirl online veterinary continuing education podcast, we review the use of long-term famotidine in dogs. How many of you have seen patients that take famotidine for weeks, months, or even years? It certainly raises the question, what impact does such chronic use have on our patients? Is it even effective? So, Tolbert et al out of University of Tennessee wanted to evaluate this in a study entitled Repeated famotidine administration results in a diminished effect on intragastric pH in dogs. In this study, they evaluated the effect of repeated famotidine administration on gastric pH and serum gastrin levels over a period of 2 weeks. The authors hypothesized that the impact of famotidine on gastric pH would diminish over time, and that its effect on day 13 would be less potent than its impact on day 1.