This audio program discusses take-home messages from the Treatment for Adolescents with Depression Study; change in negative affective bias in depressed patients after one subtherapeutic dose of an antidepressant; association between the familial aggregation of suicide and cluster B personality traits; associations among suicide attempts, gender, and sexual abuse; and a national survey of at-risk and binge drinking among middle-aged and elderly adults. Articles can be viewed online at www.ajp.psychiatryonline.org.