Featuring articles on clinical risk and therapy for breast cancer, BTK inhibition in multiple sclerosis, cardiovascular MRI vs. FFR in coronary artery disease, dual antihypertensive therapies in black Africans, and lethal strategies against tumor cells; review articles on the nonopioid treatment of pain and on heatstroke; a case report of a woman with abdominal pain and fever; and Perspective articles on misrecognition and critical consciousness, on collateral benefits of preventive chemotherapy, and on whether the genome has granted our wish yet.