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  • Abstract For Investigation of The Interaction Between Quercetin and Human Serum Albumin

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    divya1988mumbai
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    Dietary flavonoid quercetin has a broad range of biological activities, including potent antitumor activity. Human Serum Albumin (H.S.A.) is the most abundant plasma protein, involved in binding of drug molecules.

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    Abstract for Investigation of the Interaction Between Quercetin and Human Serum Albumin

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    Dietary flavonoid quercetin has a broad range of biological activities, including potent antitumor activity. Human Serum Albumin (H.S.A.) is the most abundant plasma protein, involved in binding of drug molecules.

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    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    2 views1 page

    Abstract For Investigation of The Interaction Between Quercetin and Human Serum Albumin

    Uploaded by

    divya1988mumbai
    Dietary flavonoid quercetin has a broad range of biological activities, including potent antitumor activity. Human Serum Albumin (H.S.A.) is the most abundant plasma protein, involved in binding of drug molecules.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    INVESTIGATION OF THE INTERACTION BETWEEN QUERCETIN AND HUMAN SERUM ALBUMIN

    Abstract:

    The dietary flavonoid quercetin has a broad range of biological activities, including potent antitumor activity. Human Serum Albumin (H.S.A.) is the most abundant plasma protein, involved in binding of drug molecules. In this report, the interaction between quercetin and H.S.A. was studied using fluorescence spectroscopy and Molecular Docking techniques. Through Fluorescence Spectroscopy, it was found that fluorescence quenching of H.S.A. by quercetin takes place at 296K and pH 7.4. Molecular Docking study showed that quercetin binds to H.S.A. in sub-domain IIA near the vicinity of Trp214. The interaction between quercetin and Human Serum Albumin is stable and spontaneous in nature, having a free binding energy of -75 kCal.

    - SEAT NO.: 324 (M.Sc. II Biochemistry)

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