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viii ABSTRAK

Dewi Setiawati. Peranan Inflamasi Pada Patogenesis Preeklampsia; Tinjauan tentang Interleukin-6, Interleukin-10, dan Rasio Interleukin-6/Interleukin-10 (dibimbing oleh Maisuri T. Chalid, Eddy Tiro, dan Ilhamjaya Patellongi) Penelitian ini bertujuan mengetahui peranan sitokin proinflamasi dan antiinflamasi dalam patomekanisme preeklampsia. Penelitian ini dilakukan di BLU RS Dr. Wahidin Sudirohusodo dan Rumah Sakit Jejaringnya. Metode penelitian yang digunakan adalah observasional dengan desain cross sectional study. Pengambilan sampel secara consecutive sampling dengan jumlah kasus adalah 70 orang yaitu 20 penderita preeklampsia berat, 15 preeklampsia ringan, dan 35 kehamilan normal. Analisis statistik dengan uji Kruskal Wallis, Independent t test dan uji korelasi Spearman dan uji korelasi Pearson Hasil penelitian menunjukkan Pada penelitian ini didapatkan korelasi positif kadar IL-6 terhadap TDS (r =0,706 p =0,000) demikian pula rasio IL-6/IL-10 serum (r =0,608 p=0,000). Penelitian ini juga didapatkan korelasi positif kadar IL-6 terhadap TDD (r =0,583 p =0,000) demikian pula rasio IL-6/IL-10 serum (r =0,061 p=0,000), Terdapat korelasi positif kadar IL-6 dan rasio IL-6/IL-10 yang berarti semakin tinggi kadar maka TDD semakin tinggi. Terdapat korelasi positif IL-6 dan rasio IL-6/IL-10 terhadap proteinuria (korelasi positif kadar IL-6 terhadap proteinuria (r =0,553 p =0,000). Demikian pula rasio IL-6/IL-10 serum (r =0,534 p=0,000). Tidak terdapat korelasi kadar IL-10 terhadap TDS (r =0,054; p=0,000), TDD (r =0,507; p=0,000) dan terhadap proteinuria(r =-0,098; p=0,210). Terdapat perbedaan bermakna kadar IL 6 pada preeklamsia berat 8,404 ( 4,860), preeklamsia ringan 3,781 ( 2,076) dan hamil normal 2,984 ( 1,531) dengan p = 0,000. Tidak terdapat perbedaan bermakna IL 10 pada preeklamsia ringan 3,147 (2,022), preeklamsia berat 3,959 ( 2,917) dan hamil normal 3,810 (2,159). Terdapat perbedaan bermakna rasio IL-6/IL-10 dengan rasio tertinggi pada preeklamsia berat 2,922 ( 2,368) selanjutnya preeklamsia ringan 1,420 ( 0,882) dan paling rendah hamil normal 0,912 ( 0,609). Dari hasil penelitian ini dapat disimpulkan bahwa ada peranan proses inflamasi pada patogenesis terjadinya preeklampsia.

Kata kunci: preeklampsia,IL-6.IL-10,rasio IL-6/IL-10

ix ABSTRACT

Dewi Setiawati. The Role of Inflammation in Pathogenesis of Preeclampsia; Study of Interleukin-6, Interleukin-10, and The Ratio of Interleukin-6/Interleukin-10 (led by Telly Tessy and Nusratuddin Abdullah) This study aims to identify the relationship Endoglin levels with the degree of endometriosis peritoneal fluid. The research was conducted at Hospital BLU. Dr Wahidin Sudirohusodo and Hospitals website. The method used is an observational study design with Cross Sectional Study. Sampling of Consecutive sampling with a number of cases is 80 people which 67 patients with endometriosis were classified as samples, and 13 patients with a diagnosis of not endometriosis is classified as a control. Obtained as many as 18 people endometriosis stage II, 16 stage III, and 33 stage IV. Independent t test, Mann Whitney test One-way ANOVA and LSD for different test. Significance based on p <0.05 The results showed that average levels of Endoglin group of cases is higher than the controls (15.16 ng / ml vs. 7.64 ng / ml). Endoglin mean between severe endometriosis (stage III / IV) and mild endometriosis (stage I / II) found a significant difference (15.93 ng / ml vs 13.05 ng / ml, p <0.000). Endoglin mean mild endometriosis (stage I / II) and controls found a significant difference (13.05 ng / ml vs. 7.64 ng / ml, p <0.000). Of the 67 cases obtained Endoglin levels in stage II Endometriosis is 13.05 ng / ml, in stage III endometriosis was 15.79 ng / ml and in stage IV Endometriosis is 15.99 ng / ml. Analysis of the ROC curve (Receiver Operating Characteristic) obtained the value 11.025 ng / ml as the cutpoint for the diagnosis of endometriosis Endoglin test with a sensitivity of 95.5% and a specificity of 100% From these results it can be concluded that the obtained significant differences between cases and controls Endoglin levels (p <0.05). Furthermore, increased levels of Endoglin occur according to the degree of severity of endometriosis. Key words: Endometriosis, Angiogenesis, Endoglin

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