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| 14
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)(2012
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.
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34 43
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.
.
.
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science.1231507; http://dx.doi.
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http://dx.doi.org/10.1126/
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2012
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.
1. Corman, V. M. et al. Euro Surveill. 17, 39 (2012).
2. Corman, V. M. et al. Euro Surveill. 17, 49 (2012).
3. Mller, M. A. et al. mBio 3, e00515-12 (2012).
.
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21 3
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.5
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.
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2012 Macmillan Publishers Limited. All rights reserved
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:
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1. Botimer, J. et al. Preprint at http://arxiv.org/
abs/1211.6769 (2012).
2. Zhang, X. et al. Preprint at http://arxiv.org/
abs/1211.5532 (2012).
3. Wolgast, S. 5 al. Preprint at http://arxiv.org/
abs/1211.5104 (2012).
4. Menth, A., Buehler, E. & Geballe, T. H. Phys. Rev. Lett.
22, 295297 (1969).
5. Dzero, M., Sun, K., Galitski, V. & Coleman, P. Phys.
Rev. Lett. 104, 106408 (2010).
|
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1. Richert, C., Roughton, A. L. & Benner, S. A. J. Am. Chem. Soc. 118, 45184531
(1996).
2. Switzer, C., Moroney, S. E. & Benner, S. A. J. Am. Chem. Soc. 111, 83228323
(1989).
3. Piccirilli, J. A. et al. Nature 343, 3337 (1990).
4. Bain, J. D., Switzer, C., Chamberlin, A. R. & Benner, S. A. Nature 356, 537539
(1992).
5. Schweitzer, B. A. & Kool, E. T. J. Am. Chem. Soc. 117, 18631872 (1995).
6. Moran, S., Ren, R. X.-F., Rumney, S. & Kool, E. T. J. Am. Chem. Soc. 119,
20562057 (1997).
7. Moran, S., Ren, R. X.-F. & Kool, E. T. Proc. Natl Acad. Sci. USA 94, 1050610511
(1997).
8. Leconte, A. M. et al. J. Am. Chem. Soc. 130, 23362343 (2008).
9. Yamashige, R. et al. Nucl. Acids Res. 40, 27932806 (2012).
10. Yang, Z., Chen, F., Alvarado, J. B. & Benner, S. A. J. Am. Chem. Soc. 133,
1510515112 (2011).
11. Malyshev, D. A. et al. Proc. Natl Acad. Sci. USA 109, 1200512010 (2012).
12. Pinheiro, V. B. et al. Science 336, 341344 (2012).
13. Marlire, P. et al. Angew. Chem. Int. Edn 50, 71097114 (2011).
2012 Macmillan Publishers Limited. All rights reserved
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.
.
.
.
.
2009 .
..
.2015
.
:
.
1. Meinshausen, M. et al. Nature 458, 11581162 (2009).
2. Bosetti, V. & Frankel, J. Sustainable Cooperation in Global Climate Policy: Specific
Formulas and Emission Targets to Build on Copenhagen and Cancun Discussion
paper 2011-46 (Harvard Project on Climate Agreements, 2011).
3. Prins, G. etal. The Hartwell Paper: A New Direction for Climate Policy After the
Crash of 2009 (LSE, 2010).
2012 Macmillan Publishers Limited. All rights reserved
37 | 2 0 1 3
1869
. " "Nature
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| 40
| 2013
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Seeed studio
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.
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% .
2012 Macmillan Publishers Limited. All rights reserved
.
. :
49931
129
.
pearce@mtu.edu :
1. Miller, J. C., Serrato, R. M., Represas-Cardenas,
J. M. & Kundahl, G. A. The Handbook Of
Nanotechnology: Business, Policy, and Intellectual
Property Law (John Wiley & Sons, 2005).
2. Lemley, M. A. Stanford Law Review 58, 601630
(2005).
3. Mushtaq, U. & Pearce, J. M. in Nanotechnology
& and Global Sustainability (eds Maclurcan, D.
Radywyl, N.) 191213 (CRC, 2011).
4. Makker, A. Southern California Law Review 84,
11631203 (2011).
5. Heller, M. A. & Eisenberg, R. S. Science 280,
698701 (1998).
6. Tullis, T. K. Nanotechnology Review 1, 189205
(2012).
7. Harris, D. L. in Nanotechnology & Society (eds
Allhoff, F. & Lin, P.) 163184 (Springer, 2009).
8. Stiles, A. R. Drexel Law Review 4, 555592 (2012).
9. Pearce, J. M. Science 337, 13031304 (2012).
10. Toumey, C. Nature Nanotechnol. 4, 136137
(2009).
|
41 | 2 0 1 3
11,000
RGGI
6700
) (2015
) (2010
RGGI : ) (
.
15
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.
1990
.
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( : ).
| 42
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.2001
27
( ) .
.. ( )2007-2005
.
80-40
% 4-2 .1
2012 Macmillan Publishers Limited. All rights reserved
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( .)go.nature.com/mievx3 :
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2012 Macmillan Publishers Limited. All rights reserved
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2015
.
. :
..
.
.
:
.
.
.6
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.2015
:
CB3 9EP.
mjg7@cam.ac.uk :
1. Grubb, M. Laing, T., Sato, M. & Comberti, C.
Analyses of the Effectiveness of Trading in EU-ETS
(Climate Strategies, 2012).
2. Prins, G. & Rayner, S. Nature 449, 973975
(2007).
3. Lomborg, B. A fracking good story. Project
Syndicate (13 September 2012).
4. Paterson, M. Clim. Policy 12, 8297 (2012).
5. Kosoy, A. & Guiogon, P. State and Trends of the
Carbon Market 2012 (World Bank, 2012).
6. Grubb, M. Strengthening the EU ETS (Climate
Strategies, 2012).
|
43 | 2 0 1 3
.
.
.
:
.
( :
) .
.
.
| 44
| 2013
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SOURCE: URANIUM 2011: RESOURCES, PRODUCTION AND DEMAND (OECD NEA/IAEA; 2012).
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10 .
.
.
..
.
: .
.
. .:
.
.
. :
.
sfa24@cam.ac.uk :
1. International Atomic Energy Agency. IAEA
)Safeguards Glossary 2001 Edition (IAEA, 2002
2. Alvarez, R. Managing the Uranium-233 Stockpile
of the United States (Institute for Policy Studies,
2012); available at http://go.nature.com/6exukv.
3. Codding, J. W., Berreth, J. R., Schuman, R. P.,
Burgus, W. H. & Deal, R. A. Separation and
Purification of a Gram of Protactinium-233 Atomic
Energy Commission Report IDO 17007 (1964).
4. Katzin, L. I. & Stoughton, R. W. J. Inorg. Nucl.
Chem. 3, 229232 (1956).
5. McNeese, L. E., Ferris, L. M. & Nicholson, E. L.
Molten-Salt Breeder Reactor Fuel Processing Oak
Ridge National Laboratory Technical Report No.
CONF-720522-3 (1972).
6. Whatley, M. E., McNeese, L. E., Carter, W. L., Ferris,
L. M. & Nicholson, E. L. Nucl. Appl. Technol. 8,
170178 (1970).
7. Shaffer, J. H., Moulton, D. M. & Grimes, W. R. US
Patent 3,577,225 (1971).
8. Delpech, S. et al. J. Fluorine Chem. 130, 1117
(2009).
9. Grimes, W. R., Moulton, D. M. & Shaffer, J. H. US
Patent 3,495,975 (1970).
10. International Atomic Energy Agency. Model
Protocol Additional to the Agreement(s) between
State(s) and the International Atomic Energy
Agency for the Application of Safeguards
INFCIRC/540/Corr (IAEA, 1997).
|
45 | 2 0 1 3
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| 46
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. .
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. 288$ 29.95
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| 50
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.
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.
andrew.walls@umassmed.edu
.
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486-485 7 .
.)2004
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reference panel
( .)2012 401-389 190
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.
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|
51 | 2 0 1 3
.
)(2012-1940
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2012
11
..
1964
. ..
1971
-
-
.
| 52
| 2013
.
.
1977 1983
caecilians
( haramiyids
( Tiktaalik
1981 1982 2009
(
) .
: .
60637
nshubin@uchicago.edu :
.
Nature
.
Nature
.Nature
Nature :
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naturejobs.com
..
.. naturejobs.com
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10,000
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Follow us on:
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61 .
| 1 .
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2012 Macmillan Publishers Limited. All rights reserved
63 .
.3
.5
.
.
:
. :
. :
( racemically
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. :
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..
.
.
6
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.
.
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.
keasling@berkeley.edu :
|
55 | 2 0 1 3
180
..
.
7
.
( 1)
.
..
.
()
2
() 8
.
..
.
.
9 .10
11
.12
.
.
.
| 56
| 2013
.
.
.
. ..
.
.
:
.
.
.
.
.
pbaran@scripps.edu :
1. Malpartida, F. & Hopwood, D. A. Nature 309,
462464 (1984).
2. Steen, E. J. et al. Nature 463, 559562 (2010).
3. Enserink, M. Science 307, 33 (2005).
4. Ro, D. K. et al. Nature 440, 940943 (2006).
5. Acton, N. & Roth, R. J. J. Org. Chem. 57, 36103614
(1992).
6. Siegel, J. B. et al. Science 329, 309313 (2010).
7. McDaniel, R. & Weiss, R. Curr. Opin. Biotechnol. 16,
476483 (2005).
8. Bringi, V., Kadkade, P. G., Prince, C. L. & Roach, B.L.
US patent 7264951 (2007).
9. Charest, M. G., Lerner, C. D., Brubaker, J. D., Siegel,
D. R. & Myers, A. G. Science 308, 395398 (2005).
10. Ledford, H. Nature 468, 608609 (2010).
11. Zhu, C. & Cook, S. P. J. Am. Chem. Soc. 134,
1357713579 (2012).
12. Mendoza, A., Ishihara, Y. & Baran, P. S. Nature Chem.
4, 2125 (2012).
( )
..
.
1
.
:
.
Olfactory receptor neurons
.sensilla
.2
ab3
( )ab3A, ab3B
( 2
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.
ab3A
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2012 Macmillan Publishers Limited. All rights reserved
ephaptic coupling 3
( 1-) .
.
.
.4
.
..
5
.6 ..
-
-
.
.
.
..
.7
.
20892
.
stopferm@mail.nih.gov :
1. Su, C.-Y., Menuz, K., Reisert, J. & Carlson, J. R.
Nature 492, 6671 (2012).
2. Su, C.-Y., Menuz, K. & Carlson, J. R. Cell 139, 4559
(2009).
3. Jefferys, J. G. Physiol. Rev. 75, 689723 (1995).
4. Vermeulen, A. & Rospars, J.-P. Eur. Biophys. J. 33,
633643 (2004).
5. Zacharuk, R. Y. Annu. Rev. Entomol. 25, 2747 (1980).
6. Chaudhari, N. & Roper, S. D. J. Cell Biol. 190,
285296 (2010).
7. Raman, B., Joseph, J., Tang, J. & Stopfer, M.
J. Neurosci. 30, 19942006 (2010).
|
57 | 2 0 1 3
.
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wei-jen.yankelevich@fda.hhs.gov :
.
.
hansen@wustl.edu :
..
:
.
.
.
2
.
Pluripotency
.
.
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.3
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2012 Macmillan Publishers Limited. All rights reserved
.
.
.
.4
.
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.5
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|
59 | 2 0 1 3
1
| 1 .
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.5
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.
.
.
. ..
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.
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.
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.
| 60
| 2013
. 2
.
.
.1
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..
.
.
.
.
.
transdifferentiation
( .
6
) .
.
.
. ..
.
..
. ..
.
.
.
khochedlinger@helix.mgh.harvard.edu :
1. Hayashi, K. et al. Science 338, 971975 (2012).
& 2. Hayashi, K., Ohta, H., Kurimoto, K., Aramaki, S.
Saitou, M. Cell 146, 519532 (2011).
3. Takahashi, K. & Yamanaka, S. Cell 126, 663676
(2006).
4. Daley, G. Q. Science 316, 409410 (2007).
5. Surani, M. A. & Hajkova, P. Cold Spring Harb. Symp.
Quant. Biol. 75, 211218 (2010).
6. Buganim, Y. et al. Cell Stem Cell 11, 373386
(2012).
2012 Macmillan Publishers Limited. All rights reserved
.
.
. .
.1
.
(
24
)
.
2
.
.
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2012 Macmillan Publishers Limited. All rights reserved
( 8
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( )
.
( 9
) . ..
.7-
10 .
.
.
lisa.monteggia@utsouthwestern. :
edu
1. Foster, R. G. & Wulff, K. Nature Rev. Neurosci. 6,
407414 (2005).
2. LeGates, T. et al. Nature 491, 594598 (2012).
3. Mohawk, J. A., Green, C. B. & Takahashi, J. S. Annu.
Rev. Neurosci. 35, 445462 (2012).
4. Berson, D. M., Dunn, F. A. & Takao, M. Science
295, 10701073 (2002).
5. Hattar, S., Liao, H.-W., Takao, M., Berson, D. M.
& Yao, K.-W. Science 295, 10651070 (2002).
6. Do, M. T. H. et al. Nature 457, 281287 (2009).
7. Chen, S.-K., Badea, T. C. & Hattar, S. Nature 476,
9295 (2011).
8. Hattar, S. et al. J. Comp. Neurol. 497, 326349
(2006).
9. Berton, O. et al. Science 311, 864868 (2006).
10. Autry, A. E. et al. Nature 475, 9195 (2011).
|
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| 2013
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.
. 2011
.3
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1098 104
.
bakker@amolf.nl :
1. Davis, J. G., Gierszal, K. P., Wang, P. & Ben-Amotz, D.
Nature 491, 582585 (2012).
2. Frank, H. S. & Evans, M. W. J. Chem. Phys. 13,
507532 (1945).
3. Soper, A. K. & Finney, J. L. Phys. Rev. Lett. 71,
43464349 (1993).
& 4. Dixit, S., Crain, S. J., Poon, W. C. K., Finney, J. L.
Soper, A. K. Nature 416, 829832 (2002).
5. Chandler, D. Nature 437, 640647 (2005).
6. Laage, D. & Hynes, J. T. Science 311, 832835
(2006).
7. Laage, D., Stirnemann, G. & Hynes, J. T. J. Phys.
Chem. B 113, 24282435 (2009).
8. Ishihara, Y., Okouchi, S. & Uedaira, H. J. Chem. Soc.
Faraday Trans. 93, 33373342 (1997).
9. Yoshida, K., Ibuki, K. & Ueno, M. J. Chem. Phys. 108,
13601367 (1998).
10. Petersen, C., Tielrooij, K.-J. & Bakker, H. J. J. Chem.
Phys. 130, 214511 (2009).
. ..
.
. ..
.
.
.
:
.
.
| 1 .
.
2
() . .
.
.
.
.
.
(
) .
. ..
.
.
.
()
.
.
45
.67
.8
9
.
. . :
.
gus.hart@byu.edu :
1. Sass, S. L. The Substance of Civilization (Arcade, 1998).
2. Maisel, S. B., Hfler, M. & Mller, S. Nature 491,
740743 (2012).
3. www.whitehouse.gov/sites/default/files/microsites/
ostp/materials_genome_initiative-final.pdf
& 4. Curtarolo, S., Morgan, D., Persson, K., Rodgers, J.
Ceder, G. Phys. Rev. Lett. 91, 135503 (2003).
5. Curtarolo, S. et al. Comput. Mater. Sci. 58, 218-226
(2012).
6. Curtarolo, S. et al. Comput. Mater. Sci. 58, 227235
(2012).
7. Jain, A. et al. Comput. Mater. Sci. 50, 22952310
(2011).
8. Yang, K., Setyawan, W., Wang, S., Buongiorno
Nardelli, M. & Curtarolo, S. Nature Mater. 11,
614619 (2012).
9. Nelson, L. J., Zhou, F., Hart, G. L. W. & Ozoli, V.
preprint at http://arxiv.org/abs/1208.0030 (2012).
2012 Macmillan Publishers Limited. All rights reserved
"
"..
.
.
.
( ) .
.
"" 8 1962
. .
.
.
"" 5 1912
|
65 | 2 0 1 3
. .
| 1 . 1
()
. 45
. 45-
. 20- "" .
300( . .)1
.
( ) 1
: .
.2
.
.
3
100 .
..
.
:
1901
.
..
| 66
| 2013
.
.
.
thermophoresis
.
.
1000
.
.4
.
5
.
50
532
.
( .)1
.
1.8 115/
.
.
..
.
.
.
.
optofluidics
microfluidic
.chips
6
(
) .
.7
:
.
.
..
.
.
.
:
DD1 4HN .
d.mcgloin@dundee.ac.uk :
1. Esseling, M., Rose, P., Alpmann, C. & Denz, C. Appl.
Phys. Lett. 101, 131115 (2012).
2. Ashkin, A. Phys. Rev. Lett. 24, 156159 (1970).
3. Maxwell, J. C. A Treatise on Electricity and Magnetism
Vol. 2 (Oxford Clarendon Press, 1873).
4. Shvedov, V. G. et al. Phys. Rev. Lett. 105, 118103
(2010).
& 5. Cordero, M. L., Burnham, D. R., Baroud, C. N.
McGloin, D. Appl. Phys. Lett. 93, 034107
(2008).
6. Horstmann, M., Probst, K. & Fallnich, C. Appl. Phys. B
103, 3539 (2011).
7. Schmidt, O. A., Garbos, M. K., Euser, T. G. & Russell,
P. St. J. Phys. Rev. Lett. 109, 024502 (2012).
2012 Macmillan Publishers Limited. All rights reserved
22 2012
22
.
Foxo
()
.Treg
.3
-1
Akt-Foxo1
.
- 1
.
Novel Foxo1-dependent
transcriptional programs
control Treg cell function
W Ouyang et al
doi:10.1038/nature11581
DAXX
()
.
.
.
.
.
Revealing the quantum regime
in tunnelling plasmonics
K Savage et al
doi:10.1038/nature11653
. ()DAXX
H3.3
H3.3 .
.H3.3/H4
H3.3/H4
H3.3
.H3
DAXX envelops a histone H3.3
H4 dimer for H3.3-specific
recognition
S Elssser et al
doi:10.1038/nature11608
|
.
( .)d
( )A (.)C
A
)(nm
40
30
20
10
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A
B
C
~1
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2012 Macmillan Publishers Limited. All rights reserved
600
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( )methanotrophic archaea
(.)Deltaproteobacteria
.
()
(
)
.
Zero-valent sulphur is a key
intermediatein marine methane
oxidation
J Milucka et al
doi:10.1038/nature11656
.
.
()fMRI
.
Hippocampalcortical
interaction during periods of
subcortical silence
N. Logothetis et al
doi:10.1038/nature11618
.
NOMAD
0235723-1181
23 .2011
9 1.430 :
.
451.502
(
)
.
67 | 2 0 1 3
DBCS
.
(
).
Albedo and atmospheric
constraints of dwarf planet
Makemake from a stellar
occultation
J. Ortiz et al
doi:10.1038/nature11597
SADBS
avg. max length = 27 mm
DBCS
avg. max length = 33 mm
1 cm
.
.
Aberrant light directly impairs
mood and learning through
melanopsin-expressing neurons
T LeGates et al
doi:10.1038/nature11673
(
)
.
.
-1
| 68
| 2013
SADBS
71 .
11 .
.
.
An early and enduring advanced technology
( )ATpif1
.
1-
ferrochelatase
-2Fe 2S
.
1-
.1
m .
( ).avg. max
( DBCS SADBS ) .
( ) a( 121094
133878 )b(, 266888 )c(, 280295 )d(, 266287 )e(, 107536
)f(, 259888 )g(, 312237 )h(, 151511 )i(, 272915 )j(, 155127
))k( and 177975 )l
.
Mitochondrial Atpif1 regulates
haem synthesis in developing
erythroblasts
D Shah et al
doi:10.1038/nature11536
. ..
.
()CH3F
.
.
) (
.
.
.
Water structural transformation at
molecular hydrophobic interfaces
J Davis et al
doi:10.1038/nature11570
.
GRACE
20022010
69
0.2.
Water structural transformation at
molecular hydrophobic interfaces
J Davis et al
doi:10.1038/nature11570
-
IgE FcRI
.
DERPin
(
)
()
)(
20
)f (Hz
.
Sisyphus cooling of electrically
trapped polyatomic molecules
M Zeppenfeld et al
doi:10.1038/nature11595
.
IgE-Fc
)
(
.
Accelerated disassembly of
IgEreceptor complexes by a
disruptive macromolecular
inhibitor
B Kim et al
doi:10.1038/nature11546
)(
10
90
.
( )M 500
1.5 45.
.
Synaptic amplification by
dendritic spines enhances input
cooperativity
M Harnett et al
doi:10.1038/nature11554
/
G2019S
2
LRRK2
( )
.
.
.
BTB-ZF factors recruit the
E3 ligase cullin 3 to regulate
lymphoid effector programs
R Mathew et al
doi:10.1038/nature11548
2012 Macmillan Publishers Limited. All rights reserved
60
0
0
30
)/ (
( .
) .
" "janus
.
( .)microtubes
.
.
Linking synchronization to selfassembly using magnetic Janus
colloids
J Yan et al
doi:10.1038/nature11619
|
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()
(" )Z "
" " ()H
.
()
( ) . 18
.
69 | 2 0 1 3
.
( )+Na
+Na/
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.
.
Structure and mechanism of a
bacterial sodium-dependent
dicarboxylate transporter
R Mancusso et al
doi:10.1038/nature11542
3
3
3
ubiquitination
.
3
PLZF
BCL6 ()
.
BTB-ZF factors recruit the
E3 ligase cullin 3 to regulate
lymphoid effector programs
R Mathew et al
doi:10.1038/nature11548
| 70
| 2013
29 2012
29
.
.
2.24.8
( )
(.)IPCC
Making sense of palaeoclimate
sensitivity
E Rohling et al
doi:10.1038/nature11574
.
.
()
.
.
.
.
The mystery of recent
stratospheric temperature trends
D Thompson et al
doi:10.1038/nature11579
% 0.1
.
NGC4486B
% 11
17
% 59
NGC1277
NGC1277
.
An over-massive black hole in
the compact lenticular galaxy
NGC 1277
R van den Bosch et al
doi:10.1038/nature11592
|
NGC1277
.
19x8
.
1
.
. NGC1277
0.3
.
0.3
< 1 % 24
.
.
.
.
.
.
2012 Macmillan Publishers Limited. All rights reserved
2004
.
.
()
600
500-450
500-450
.
Active upper-atmosphere
chemistry and dynamics from
polar circulation reversal on Titan
N Teanby et al
doi:10.1038/nature11611
( )HSE
1-
.
.
( )iPSCs
( )TLR3(UNC-
.)93B
1-
.
( )
.1-
.
Impaired intrinsic immunity to
HSV-1 in human iPSC-derived
TLR3-deficient CNS cells
F Lafaille et al
doi:10.1038/nature11583
)(
)(
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% 10
.
( )MAIT
( .)MR1
( )MR1
( )MHC
( )pterin
.-9
( )MAIT
( )MAIT
.
MR1 presents microbial vitamin
B metabolites to MAIT cells
L Kjer-Nielsen et al
doi:10.1038/nature11605
()RNA
.
.
.
() ().
The genomic landscape of species divergence in Ficedula
flycatchers
H Ellegren et al
doi:10.1038/nature11584
( .)
|
.
() .
.
2012 Macmillan Publishers Limited. All rights reserved
.
Visualizing transient lowpopulated structures of RNA
E Dethoff et al
doi:10.1038/nature11498
|
71 | 2 0 1 3
.
17 (17
).
454
.
.
.
5.1
( )cDNA
()RNA
.
Analysis of the bread wheat
genome using whole-genome
shotgun sequencing
R Brenchley et al
doi:10.1038/nature11650
A physical, genetic and
functional sequence assembly
of the barley genome
K mayer et al
doi:10.1038/nature11543
|
()
.
( :)a
.
/
( )FPC
. 1H
.( :)b
( :)c
( .)d( :)d
( )LTR I-()e
DNA II-(.)f
( :)g
( )BACs .
.
.
.
( ).
226
81
.
| 72
| 2013
.
Global convergence in the
vulnerability of forests to drought
B Choat et al
doi:10.1038/nature11688
()stiffness
.
.
.
.
A canonical stabilityelasticity
relationship verified for one
million face-centred-cubic
structures
S Maisel et al
doi:10.1038/nature11609
150
.
.
.
Rapid coupling between ice
volume and polar temperature
over the past 150,000 years
K. Grant et al
doi:10.1038/nature11593
(
)
.
.
.
.
Amap of visual space in the
primate entorhinal cortex
N Killian et al
doi:10.1038/nature11587
.
..
.
The global pattern of traceelement distributions in ocean
floor basalts
H ONeill et al
doi:10.1038/nature11678
.
.
65
.
Self-renewal of embryonicstem-cell-derived progenitors
by organ-matched mesenchyme
J Sneddon et al
doi:10.1038/nature11463
( )ERVs
.
)(
( )Placoderms
.
.
. ..
.
Development of teeth and jaws in the earliest jawed vertebrates
P Donoghue et al
doi:10.1038/nature11555
|
.
.
.
Resurrection of endogenous
retroviruses in antibodydeficient mice
G Young et al
doi:10.1038/nature11599
2012 Macmillan Publishers Limited. All rights reserved
CXCR1
GPCRs
G-
.
73 | 2 0 1 3
( )CXCR1 GPCR
8-
.
Structure of the chemokine
receptor CXCR1 in phospholipid
bilayers
S Park et al
doi:10.1038/nature11580
.
)http://creativecommons.org/
(licenses/by-sa/3.0/deed.en
Identification of a rudimentary
neural crest in a non-vertebrate
chordate
P Abitua et al
doi:10.1038/nature11589
6 2012
6
.
.
()
.
.
.
Ciona
intestinalis
()
.
()
.
| 74
| 2013
.
.2.1
L1527 IRS
.0.2 L1527
() .
A ,0.2-solar-mass protostar
with a Keplerian disk in the
very young L1527 IRS system
J Tobin et al
doi:10.1038/nature11610
( )
.
ephaptic
.
.
.
()
.
.
Non-synaptic inhibition
between grouped neurons in
an olfactory circuit
C Su et al
doi:10.1038/nature11712
C-H
C-C
C-H
.
Practical and innate carbon
hydrogen functionalization of
heterocycles
Y Fujiwara et al
doi:10.1038/nature11680
/
.
The root of branching river
networks
J. Perron et al
doi:10.1038/nature11672
/
.
.
.
The entorhinal grid map is
discretized
H Stensola et al
doi:10.1038/nature11649
.z=3
.
()
z=7.04
% 5.6 .
.
.
Extremely metal-poor gas at a
redshift of 7
R Simcoe et al
doi:10.1038/nature11612
iridoid synthase
iridoid
.
An alternative route to cyclic
terpenes by reductive cyclization
in iridoid biosynthesis
F Geu-Flores et al
doi:10.1038/nature11692
/
EZH2
EZH2
)PCR2( 2
( )H3
27 (.)H3K27
()
( )EZH2
27
.PCR2
EZH2
.
..
EZH2
.
EZH2 inhibition as a therapeutic
strategy for lymphoma with
EZH2-activating mutations
M McCabe et al
doi:10.1038/nature11606
/
( )EHEC
.
.
.
( )glycans
.
.
Fucose sensing regulates
bacterial intestinal colonization
A Pacheco et al
doi:10.1038/nature11623
57
MT
34
NM
284
PY
c
145
NM
487
PY
PPC
PPC
21,708
MT
36
24,840
.
:
.
.
Algal genomes reveal evolutionary mosaicism and the fate of
nucleomorphs
B Curtis et al
doi:10.1038/nature11681
| .
. ()
PPC
( )NM .
( )MT
. C : PY .
( )
.riboswitch
.
2012 Macmillan Publishers Limited. All rights reserved
( )12
( ) .
.
B12 cofactors directly stabilize
an mRNA regulatory switch
J Johnson Jr et al
doi:10.1038/nature11607
|
75 | 2 0 1 3
)(
)(
)(
17 nm
3.6 nm
()
.
.
..
.
.
.
.
Controlled-reflectance surfaces
with film-coupled colloidal
nanoantennas
A Moreau et al
doi:10.1038/nature11615
| .)
)
)
17.1%
| 76
| 2013
) .)
.% 1
3.6 17.
( )GaAs
.
.
Continuous gas-phase
synthesis of nanowires with
tunable properties
M Heurlin et al
doi:10.1038/nature11652
NLRP3
.
-
( )NLRP3
CaSR
NLRP3
( )CAPS
.
NLRP3
.
The calcium-sensing receptor
regulates the NLRP3
inflammasome through Ca21
and cAMP
G Lee et al
doi:10.1038/nature11588
/
.
( )
.
15-23-
.
23-
.15-
.
Structure of a force-conveying
cadherin bond essential for
inner-ear mechanotransduction
M Sotomayor et al
doi:10.1038/nature11590
1-
1-
..
.
.
.
HIV therapy by a combination
of broadly neutralizing
antibodies in humanized mice
F Klein et al
doi:10.1038/nature11604
13 2012
13
.
( )OLEDs
-
""
(
% 75
) .
.
.
..
.
% 19
OLEDs .
Highly efficient organic lightemitting diodes from delayed
fluorescence
H Uoyama et al
doi:10.1038/nature11687
|
()CDCB .
.
365
()
.cytokinesis
( )
.
MgcRacGAP
.
Centralspindlin links the
mitotic spindle to the plasma
membrane during cytokinesis
S Lekomtsev et al
doi:10.1038/nature11773
TatC
Tat
.
. ( )Tat
.
Tatc
.
Aquifex
aeolicus
.
Structure of the TatC core of the
twin-arginine protein transport
system
S Rollauer et al
doi:10.1038/nature11683
SIRT2
TNF
1-
RIP1
.RIP3 3-
SIRT2
.RIP33
SIRT2
RIP1-
RIP3
TNF
. RIP1
SIRT2
RIP1RIP3
.TNF
()
RIP1
.SIRT2
SIRT2
. ..
SIRT2
.
The NAD-dependent
deacetylase SIRT2 is required
for programmed necrosis
N Narayan et al
doi:10.1038/nature11700
)SV40( 40
()T-Ag
( )DNA
-
.
.
Bypass of a protein barrier by a
replicative DNA helicase
H Yardimci et al
doi:10.1038/nature11730
2012 Macmillan Publishers Limited. All rights reserved
800/
.
% 75
.
Automated design of ligands
to polypharmacological profiles
J Besnard et al
doi:10.1038/nature11691
()
.
.
.
N-body
.
.
..
.
Formation of the widest binary
stars from dynamical unfolding
of triple systems
B Reipurth et al
doi:10.1038/nature11662
..
|
77 | 2 0 1 3
.
SecYEG
.
( )RNAs
.
Activated GTPase movement
on an RNA scaffold drives
co-translational protein targeting
K Shen et al
doi:10.1038/nature11726
/
XMM
Fe16+
Fe XVII .
Fe XVII
3.6
.
An unexpectedly low oscillator
strength as the origin of the Fe
XVII emission problem
S. Bernitt et al
doi:10.1038/nature11627
| 78
| 2013
, .
.
.
.
Mid-infrared frequency comb
based on a quantum cascade
laser
A Hugi et al
doi:10.1038/nature11620
.
-
()Mg,Fe
.
.
Deep penetration of molten
iron into the mantle caused by
a morphological instability
K Otsuka et al
doi:10.1038/nature11663
/
TEL-ling
TPP1
TPP1
( )DNA
.
100
29
93
17
86
20
13
) % (
pH
.Saccharomyces cerevisiae
.
.
lumen .
.
An early age increase in vacuolar pH limits mitochondrial
function and lifespan in yeast
A Hughes et al
doi:10.1038/nature11654
|
.VMA1
( )5-0
( .)= 30 .
. ()
. DIC .
.Tom70GFP
.
TPP1
.
TPP1 TEL
.
TEL
.
The TEL patch of telomere
protein TPP1 mediates
telomerase recruitment and
processivity
J Nandakumar et al
doi:10.1038/nature11648
.
serine
glycine
.
()
()
() .
.
Nonlinear dendritic integration
of sensory and motor input
during an active sensing task
N Xu et al
doi:10.1038/nature11601
.
.
Lys48 Lys63 Met1
.
FRET
( )
.
.
Ubiquitin chain conformation
regulates recognition and
activity of interacting proteins
Y Ye et al
doi:10.1038/nature11722
()ATP
( )DNA
.
ISWI
( .)DNA
.
Regulation of ISWI involves
inhibitory modules antagonized
by nucleosomal epitopes
C Clapier et al
doi:10.1038/nature11625
-1
.NF-B
GTPases
cadherin
.
.
2012 Macmillan Publishers Limited. All rights reserved
.
30 % 65
.
1.25
2500
.
Increased future ice discharge
from Antarctica owing to
higher snowfall
R.Winkelmann et al
doi:10.1038/nature11616
|
.
.
PISM-PIK Model
.
.
.
.
79 | 2 0 1 3
83 .
87 .
www.naturejobs.com :
C. J. BURTON/CORBIS
2011
.
600
.
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: .
..
2012 Macmillan Publishers Limited. All rights reserved
81 | 2 0 1 3
.
..
..
.
.
| 82
| 2013
2012 Macmillan Publishers Limited. All rights reserved
IBN
).
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.
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2011
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2011
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75 80
.
.
2002
( )A*STAR
.
5.3
38% .
Biopolis
9
2000
.
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:
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2003
.
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.
2012 Macmillan Publishers Limited. All rights reserved
.
.
:
. :
. .
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( )NCATS
:
.
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576
( 481 128
.)2012
|
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.
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( )RPF
.
:
:
.
. :
.
.
.
.
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.
( )http://addconsortium.org
.
.
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.
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| 84
| 2013
( )NINDS
.
. :
( .
461 554 555 .)2009
.
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.
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.
(.
. . .3246-3227 53 . .)2010
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)(
?X. W. Wang et al. Exploring scientists working timetable: Do scientists often work overtime
J. Informetr. 6, 655660, 2012 with permission from Elsevier.
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