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A simple algorithm
Malingering Rapid fall in GFR leading to increased waste products
Relevance
Complicates up to 7% of admissions Mortality when dialysis is required ranges 50%-75%
DDX
Diagnostic Approach
Cr/BUN, UOP, serum cystatin K, IL18 H&P Meds Labs Imaging
Acute or Chronic?
History Previous creatinine Small kidneys on u/s
Obstruction excluded?
History Complete anuria Palpable bladder Renal u/s
Euvolemic?
Pulse, JVP/CVP, orthostatic, wgt, I/O Disproportionate inc in urea:Cr ratio FENA Fluid challenge
Treatment
Prevention
Risk factors (age,DM,HTN,Vasc,renal) Maintain BP and Volume, avoid neprhotox Measure plasma aminoglycoside Allopurinol/urine alk in cancer
General
Correct prerenal/postrenal factors Optimise CO, RBF Review meds Monitor I/O Nutritional support Treat infection, bleeding Start dialysis before uremic
No strong evidence
Loop diuretic Dopamine Natriuretic peptide Intermittent HD vs Continuous ILF Thyroxine
ATN
Sepsis in ICU 35-50% Prerenal azotemia spectrum with ischemic ATN Initiation, maintenance, recovery BUN/Cr normal 10:1 Rapid rise plasma Cr Muddy brown epi casts FENa > 2% Ucr / PCr
Post Op
18-40% hospital aquired. 1.2% surgery. Pre-op BP control (Carmaichael J Surgery 2003) Hydration and prevention Poor prognosis of ARF when adjusted
(Svensson J Vasc Surg 1989)
Nephrology
Contrast
Isotonic crystalloid 1-1.5ml/kg for 3-12 hours pre proc and 6-24 hours post Mucomyst not consistently useful Current eval of theophyline, statins, vit c, pg E CCB, L-arg, fenoldopam, dopamine, ANP not useful Prophylactic HD no gain
(Stacul 2006 CIN consensus working panel)