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Mason, B. G., Pyle, D. M. & Oppenheimer, C. Bull. Volcanol. 66, 735748 (2004).
Isaia, R., Marianelli, P. & Sbrana, A. Geophys. Res. Lett. 36, L21303 (2009).
Fisher, M. C. et al. Nature 484, 186194 (2012).
Haas, B. J. et al. Nature 461, 393398 (2009).
Melott, A. L. & Thomas, B. C. Astrobiology 11, 343361 (2011).
Melott, A. L. et al. Int. J. Astrobiol. 3, 5561 (2004).
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. .

.2012
1. Gandhi, N. R. et al. Lancet 368, 15751580 (2006).
2. Cole, S. T. et al. Nature 393, 537544 (1998).
& 3. Udwadia, Z. F., Amale, R. A., Ajbani, K. K.
Rodrigues, C. Clin. Infect. Dis. 54, 579581 (2012).
|
35 | 2 0 1 3
.
.

.
.
. :
. 1963

.

.. ()Pisaster ochraceus

| 36
| 2013

.1999


MARIAN A KOHN

:
.1
1

:
..

.

.

.

. ..

.

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:

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.

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..

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37 | 2 0 1 3
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.
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.

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.
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.
1969
19 .
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.

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1900
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1997 ) 2011 (.

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.

.

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.
( ) .
.
: . :
| 38
| 2013

( 814-812 466.)2010
: .
: ()
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:

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:

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.
1997

NATURE.COM
go.nature.com/olfjxo
1992 .1993
2009

.


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1989 .:
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;L TO R: COURTESY OF BRUCE MENGE & JANE LUBCHENCO

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2012 ) (
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. :
.
. 5

. :

.
6 2005

.
.

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. :

.
. ..

.
79
.

:

.

.

. :
.
.
25
1995
..
. :
.

.

.
:
Paine, R. T. Am. Nat. 100, 6575 (1966).
Paine, R. T. Nature 355, 7375 (1992).
Lubchenco, J. & Menge, B. A. Ecol. Monogr. 48, 6794 (1978).
Menge, B. A. et al. Ecol. Res. 17, 116 (2002).
Kinlan, B. P. & Gaines, S. D. Ecology 84, 20072020 (2003).
Gaylord, B., Gaines, S. D., Siegel, D. A. & Carr, M. H. Ecol. Appl. 15, 21802191
(2005).

1.
2.
3.
4.
5.
6.
39 | 2 0 1 3
Receive exclusive discounts from top suppliers of lab

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44 .

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48 .

51 .
CORBIS
. ( ) ( ) .1945

. ..

H5N1
.2011
1 .

(

)go.nature.com/wxeijg
|
41 | 2 0 1 3
- ..

| 42
| 2013
1975

Asilomar
..

US NATL LIB. MED.

.2012

.1,2 ..

. ..

1946
4
.

(
.

(
)

.4

.6

-

.
1976

.
.

-
1977-

( ) .1975


BETTMANN/CORBIS

..

.6
(
Biogen

Genzyme
Biogen
Idec
Millennium
.Pharmaceuticals

..
.

1975

. ..

..
..

.7 .. 2005

Proceedings of the
8
National Academy of Sciences

.
9

10
2007

10

.

US National Science
.Advisory Board for Biosecurity- NSABB

.go.nature.com/wocmeh :

. ..

.
:

. :

;dikaiser@mit.edu :

morenojd@upenn.edu
Maher, B. Nature 485, 431434 (2012).
Butler, D. Nature 486, 449450 (2012).
Weart, S. R. Phys. Today 29, 2330 (1976).
Kaiser, D. Representations 90, 2860 (2005).
Berg, P., Baltimore, D., Brenner, S., Roblin, R.O.
& Singer, M. F. Proc. Natl Acad. Sci. USA 72,
19811984 (1975).
6. Durant, J. in Becoming MIT: Moments of Decision
(ed. Kaiser, D.) 145163 (MIT Press, 2010).
7. Mirowski, P. Science-Mart: Privatizing American
Science (Harvard Univ. Press, 2011).
8. Wein, L. M. & Liu, Y. Proc. Natl Acad. Sci. USA 102,
99849989 (2005).
9. Kaiser, J. Science 309, 31 (2005).
10. National Research Council Science and Security
in a Post 9/11 World (National Academies Press,
2007).
1.
2.
3.
4.
5.
43 | 2 0 1 3
2012
.
2012
.

125

. %5

%95
12
2007

.
2008
( )
10
138 .

40
34
.
1998

%60
2010
.

40
2000
5
| 44
| 2013
2011.2012

( 2002 .)6

.7
60-30

. ..
)
(

.
2010

10-8
.5
2012

10

.
.2010

. ..

:
ECMWF

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3500
. ..

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.8

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51

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..

. ..

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6 .
..
10 .

34
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..
.1998
) .

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.
.4

2009

2004

.2007

.

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.

RIMES

2004
.34

.
%80

.
2007
SOURCE: CEGIS/UNOSAT

.

:

15-10

3-2 .

10

.
.

:
.
.

pjw@eas.gatech.edu :

1. Webster, P. J. Nature Geosci. 1, 488490 (2008).
2. Belanger, J. I., Webster, P. J., Curry, J. A. & Jelinek,
M. T. Weather Forecast. 27, 757769 (2012).
3. Hopson, T. M. & Webster, P. J. J. Hydrometeorol. 11,
618641 (2010).
4. Webster, P. J. et al. Bull. Am. Meteorol. Soc. 91,
14931514 (2010).
5. Webster P. J., Toma, V. E. & Kim, H.-M. Geophys.
Res. Lett. 38, L04806 (2011).
6. Webster, P. J. & Hoyos, C. Bull. Am. Meteorol. Soc.
85, 17451765 (2004).
7. Stephens, G. L. et al. J. Clim. 17, 22132224
(2004).
8. Leutbecher, M. & Palmer, T. N. J. Comp. Phys.
227, 35153539 (2008).
9. Teisberg, T. J. & Weiher, R. F. Background Paper on
the Benefits and Costs of Early Warning Systems for
Major Natural Hazards (World Bank, 2009).
10. Foresight Reducing the Risks of Future Disasters:
Priorities for Decision Makers (UK Govt Office of
Science, 2012).
|
45 | 2 0 1 3

ANTONIO SCORZA/AFP/GETTY
.2000
...
.
(
.
.)2

.
| 46
| 2013

.

1984
( .)3

. ..
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.4

.

( 5
).

.

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(
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67
.

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.7


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200
150
100
50

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()

:

SOE-2
95064
.
:

95616

.
cboettig@ucdavis.edu :

amhastings@ucdavis.edu
1. Scheffer, M. et al. Nature 461, 5359 (2009).
2. World Economic Forum Global Risks 2013
(in the press).
3. Wissel, C. Oecologia 65, 101107 (1984).
4. Dai, L., Vorselen, D., Korolev, K. S. & Gore, J.
Science 336, 11751177 (2012).
5. Drake, J. M. & Griffen, B. D. Nature 467, 456459
(2010).
6. Hastings, A. & Wysham, D. B. Ecol. Lett. 13,
464472 (2010).
7. Schreiber, S. & Rudolf, V. H. W. Ecol. Lett. 11,
576587 (2008).
8. Lade, S. J. & Gross, T. PLoS Comput. Biol. 8,
e1002360 (2012).
& 9. Dakos, V., Kfi, S., Rietkerk, M., van Nes, E. H.
Scheffer, M. Am. Nat. 177, E153E166 (2011).
10. Boettiger, C. & Hastings, A. J. R. Soc. Interface 9,
25272539 (2012).
|
47 | 2 0 1 3

NOAA
.
1820

-
.
135
17
.
-

-
| 48
| 2013
:
:
1851
.
( 2011

) .
.
32

Cetology

.

1839

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:
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macrocephalus
()
NATURE.COM
.K. breviceps

:
go.nature.com/7ykg2n
:
.
.

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mysticetus .
.

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. 1999

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: .Leviathan

.

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.

phoare@themovement.demon. :
co.uk
.
-
49 | 2 0 1 3
L5
.1975

.

.

- nanobots

-

LSD

Whole Earth Catalog

Transhumanism

.Electronic frontier
1986

(

)

.Omni

| 50
| 2013

The
Limits to growth

1972

:

.

.
.
328 .2012 :

,19.95 .
$29.95

.

.1969

..

NATURE.COM
go.nature.com/rzxvhe
.
. :
.
.

cyrus.mody@rice.edu :
RICK GUIDICE/NASA
: .

1972

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.1972

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. go.nature.com/hijnsu


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. ..

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.

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.
frank.udovicic@rbg.vic.gov.au

| 52
| 2013

( .)2012 36-34 492
1000

.

. ..

.

1000

.

.

.

.
woodgett@lunenfeld.ca

( +20 .
35 491 .)2012

.

..

( .

.)Glob. Environ. Polit 6, 1 -22; 2006
.

.
s.dessai@leeds.ac.uk

Naturwissenschaften
.
.

.
.1935
:
13

( 136
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( 1942
284 150 .)1942

100

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.

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joan.robinson@springer.com
4G

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(
its4growth.co.uk :

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.

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:

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)Sustainability 3, 20272049; 2011

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4.3 10 .

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( 185-183 491 .)2012

-

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.

( ) .
-

.

.

.
s.h.flowers@brighton.ac.uk

.
:

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( 491
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.

. ..
.

.
stephen.johnston@asu.edu

22.7
1990 33.9


( 658-656 491 .)2012

.

.

( . .Curr. Opin.
.)Environ. Sustain 2, 245-250; 2012 .

.

( :.
667-666 491 .)2012

.
liuzhu@iae.ac.cn

.

correspondence@nature.com

:
http://go.nature.com/cmchno
53 | 2 0 1 3
.
)(2012 1919
.

| 54
| 2013

.
1959

(

)
1990

.
1993

1970
.1979
1945

.

.
1965
.

pmorris@rcseng.ac.uk :
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.
.1954

.1990
1919

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26

1940
.

.1947
.1954

.

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1954
.
.
6 ( )6-Mp

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.
1960

.
..
aza-thioprine

. ..

.1963
1971

1986

1972
1985
IMPACT
WEVE GOT SOMETHING TO SHOW YOU.
nature.com/Tapin

" "nature.com

.

.. !
nature.com/scientificreports
58 .

65 .

62 .

.
40

.
.
)(
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0.5

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1.0
1.0
0
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(
- 1
) .

.
1962 2

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( )

.

.

.

.

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.

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)(
0
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| 1 ( .)d.c.-SQUID d.c.-SQUID
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(

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.

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.

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)1

.7

.

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()
-

(
)

.

8
.
( )

.9

.

.10

| 58
| 2013

- .

()

.
. :
()
.
simmonds@boulder.nist.gov :

1. Giazotto, F. & Martnez-Prez, M. J. Nature 492,

401405 (2012).
2. Josephson, B. D. Phys. Lett. 1, 251253 (1962).
3. Clarke, J. & Braginski, A. I. (eds) The SQUID
Handbook (Wiley-VCH, 2004).
4. Langenberg, D. N. Rev. Phys. Appl. 9, 3540 (1974).
5. Maki, K. & Griffin, A. Phys. Rev. Lett. 15, 921923
(1965).
& 6. Guttman, G. D., Nathanson, B., Ben-Jacob, E.
Bergman, D. J. Phys. Rev. B 55, 38493855 (1997).
7. Giazotto, F. & Martnez-Prez, M. J. Appl. Phys. Lett.
101, 102601 (2012).
8. Eom, J., Chien, C.-J. & Chandrasekhar, V. Phys. Rev.
Lett. 81, 437440 (1998).
9. Dubi, Y. & Di Ventra, M. Rev. Mod. Phys. 83,
131155 (2011).
10. Irwin, K. D. Sci. Am. 295, 8694 (2006).
..
SIRT6
6-
.

.
Warburg
effect

2 Cell

6-

3
6-

.4

( )MEFs

6- SIRT6
( )MEFs

6-

)1
(
3
.

6-

.

.
:
6-

.

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6-
)(DNA

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. ..

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. 6-
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DNA
.. 6-
NF-B

.
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6-
.

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6-

. ..

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6-

..

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.

6-
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.

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6-
.

6-

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NF-B
16

6-

.6-
6-

6-
6-

6-
6-
.

.38
..
6-
. :
94304
.
kfchua@stanford.edu :

1. Levine, A. J. & Puzio-Kuter, A. M. Science 330,
13401344 (2010).
2. Sebastin, C. et al. Cell 151, 11851199 (2012).
3. Tennen, R. I. & Chua, K. F. Trends Biochem. Sci. 36,
3946 (2011).
4. Hanahan, D. & Weinberg, R. A. Cell 144, 646674
(2011).
5. Hahn, W. C. et al. Nature 400, 464468 (1999).
6. Min, L. et al. Nature Cell Biol. 14, 12031211 (2012).
7. Xiao, C. et al. J. Biol. Chem. 287, 4190341913 (2012).
8. Kanfi, Y. et al. Nature 483, 218221 (2012).
|
59 | 2 0 1 3
)NASA, ESA & THE HUBBLE HERITAGE TEAM (STSCI
2012

2012
()Nature 483, 546548; 2012

.
.

.

.
(Nature 483, 613617 )2012

()Nature 482, 164165; 2012

.

..

.
.
.

. ..
.
.
( )3-bit .
(J. Phys. A 44, 492002 )2011

. ()Nature 485, 314317; 2012

| 60
| 2013
. ()Nature 488, 600601; 2012

. 1959

.
NGC2207( IC 2163 ).
(Astrophys. J. 753, 7, 8, 9 )2012
.

.

. ..

(Nature 485, 321326, 327332, 395399, 400404 )2012

()Nature 484, 170171; 2012

.
()AMO

()AMO

.

366
.

(Nature 484, 228232 )2012
()Nature 486, 36-37; 2012
FOODCOLLECTION RF/GETTY IMAGES

()

.

%30
.

.
(.Nature 486, 109112 )2012

. . ()Nature 485, 584585; 2012
.

.

Bilophila wadsworthia

.
.
Nature 487, 104108 )2012(.

()Nature 485, 176177; 2012

.

.
( )DNA
. .

.

()tile

()
.
( ) .

.
(Nature 485, 623626 )2012

()Nature 487, 4748; 2012
.

.
.

.

.

.

.
Nature 485, 229232 )2012(.

61 | 2 0 1 3

.
.
)(
)(

.
| 1

.

.

2

.

( ) . ..
.

.

recalcitrance
.1
()

.
2
| 62
| 2013

( )

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cellulase

.cellulosome3

.
lignocellulosic

.

( )RFS
2005

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.

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..
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.2022

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.7

. ..

.

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. ..

. ..

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.
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()

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.schlerenchyma

.8

.

.

.
.
1

.

.2

( .)1

.
( 2.5
10 )

.

.54

. :
.
richard.dixon@unt.edu :

1. Himmel, M. E. et al. Science 315, 804807 (2007).
2. Ding, S.-Y. et al. Science 338, 10551060 (2012).
3. Bomble, Y. J. et al. Biol. Chem. 286, 56145623
(2011).
4. National Academy of Sciences. www.nap.edu/
openbook.php?record_id=13105&page=R1 (2011).
5. Studer, M. H. et al. Proc. Natl Acad. Sci. USA 108,
63006305 (2011).
6. Chapple, C., Ladisch, M. & Meilan, R. Nature
Biotechnol. 25, 746748 (2007).
7. Hoffmann, L. et al. Plant Cell 16, 14461465 (2004).
8. Yang, J. Bioenergy Res. 2, 257266 (2009).
. ..

()

( Cenozoic 2.5 )
.
()

.

. ..
JEFFREY YAP, JEFF RYAN STUDIO/GETTY
SEAN BAGSHAW/SPL
)(
)(
| 1 () .
3

.
: .
2.5 .

. .
.

63 | 2 0 1 3

.
( )MPT 950

100 .

6,7

.
3

3,9
8
.

.

. 10
.

.
.
()
.
11

.

.

.12

13

7

.
..1

1921
.

.

1969
.2

.34

| 64
| 2013

. ..

.

- .5
-
()
6

..
.

:( )()
10,14

.
. :

.

shb@manchester.ac.uk :

1. Stone, P. H. & Carlson, J. H. J. Atmos. Sci. 36,

415423 (1979).
2. Brozovi, N., Burbank, D. W. & Meigs, A. J. Science
276, 571574 (1997).
3. Pedersen, V. K. & Egholm, D. L. Nature 493,
206210 (2013).
4. Johnson, W. D. J. Geol. 12, 569578 (1904).
5. Gilbert, G. K. J. Geol. 12, 579588 (1904).
& 6. Haeuselmann, P., Granger, D. E., Jeannin, P.-Y.
Lauritzen, S.-E. Geology 35, 143146 (2007).
7. Valla, P. G., Shuster, D. L. & van der Beek, P. A.
Nature Geosci. 4, 688692 (2011).
8. Braun, J., Zwartz, D. & Tomkin, J. H. Ann. Glaciol. 28,
282290 (1999).
& 9. Egholm, D. L., Knudsen, M. F., Clark, C. D.
Lesemann, J. E. J. Geophys. Res. 116, F02012 (2011).
& 10. Anders, A. M., Roe, G. H., Montgomery, D. R.
Hallet, B. Geology 36, 479482 (2008).
11. Iverson, N. R. Geology 40, 679682 (2012).
12. Herman, F., Beaud, F., Champagnac, J.-D., Lemieux,
J.-M. & Sternai, P. Earth Planet. Sci. Lett. 310,
498508 (2011).
13. Riihimaki, C. A., MacGregor, K. R., Anderson, R. S.,
Anderson, S. P. & Loso, M. G. J. Geophys. Res. 110,
F03003 (2005).
14. Rowan, A. V., Plummer, M. A., Brocklehurst, S. H.,
Jones, M. A. & Schultz, D. M. Geology http://dx.doi.
org/10.1130/G33829.1 (2012).

- 723

620

( ) -
- ( 1-) . -

-
- ( )
.
( )
L1 :
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A-
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2006

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.9

.

. :

.

stevan.hubbard@med.nyu.edu :

1. Ward, C. W. & Lawrence, M. C. Front. Endocrinol. 2,
76 (2011).
2. Menting, J. G. et al. Nature 493, 241245 (2013).
3. Stroud, R. M. & Wells, J. A. Sci. STKE 2004, re7 (2004).
4. Wang, X., Lupardus, P., Laporte, S. L. & Garcia, K. C.
Annu. Rev. Immunol. 27, 2960 (2009).
5. Lemmon, M. A. & Schlessinger, J. Cell 141,
11171134 (2010).
6. Hubbard, S. R. & Miller, W. T. Curr. Opin. Cell Biol. 19,
117123 (2007).
7. De Meyts, P. Trends Biochem. Sci. 33, 376384
(2008).
8. McKern, N. M. et al. Nature 443, 218221 (2006).
9. Pandyarajan, V. & Weiss, M. A. Curr. Diab. Rep. 12,
697704 (2012).

.
.

.

.

.
( )

. ..
1

.

.

( .)1

|
65 | 2 0 1 3
)(
)(
)(
)(

| 1 .. . :

. ( )

(( .)monomers )

.
( )

( monomers .)1

.

.

()
.

.

2

.

( .)2

.
!

3

.

( )
. ..

...

4
.

| 66
| 2013
4
.

.

.

.

.

5

)(
)(
.
| 2
(
)
.

.

.

.

() . 1
.

( )

( )DNA .6

.

( .)2
.

7
.

.

8
.

shear
.

9

( .)shear thickening

.

10 supersolids

.

.
:

.
:
( )CNR-ISC .
francesco.sciortino@uniroma1.it; :

emanuela.zaccarelli@cnr.it
1. Lenz, D. A., Blaak, R., Likos, C. N. & Mladek, B. M.
Phys. Rev. Lett. 109, 228301 (2012).
& 2. Klein, W., Gould, H., Ramos, R. A., Clejan, I.
Melcuk, A. I. Physica A 205, 738746 (1994).
3. Mladek, B. M., Gottwald, D., Kahl, G., Neumann, M.
& Likos, C. N. Phys. Rev. Lett. 96, 045701 (2006).
4. Narros, A., Moreno, A. J. & Likos, C. N. Soft Matter
6, 24352441 (2010).
5. Li, Y. et al. Nature Mater. 3, 3842 (2004).
6. Seeman, N. C. Nature 421, 427431 (2003).
7. Zhang, K., Charbonneau, P. & Mladek, B. M. Phys.
Rev. Lett. 105, 245701 (2010).
8. Coslovich, D., Bernabei, M. & Moreno, A. J. J.
Chem. Phys. 137, 184904 (2012).
9. Nikoubashman, A., Kahl, G. & Likos, C. N. Phys.
Rev. Lett. 107, 068302 (2011).
10. Cinti, F. et al. Phys. Rev. Lett. 105, 135301 (2010).


OUTLOOK
Psoriasis
T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E
ONE YEAR. TEN STORIES.

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.

135

.

.

121

.
Seventy-five genetic loci
influencing the human red
blood cell
J Chambers et al
doi:10.1038/nature11677
/

iPSCs

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spin-liquid state of a kagomelattice antiferromagnet
T Han et al
doi:10.1038/nature11659
Somatic copy number mosaicism

in human skin revealed by
induced pluripotent stem cells
A Abyzov et al
doi:10.1038/nature11629

X
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doi:10.1038/nature11737
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doi:10.1038/nature11669
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M Warden et al
doi:10.1038/nature11617

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of the viscous anisotropy of
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L. Hansen et al
doi:10.1038/nature11671
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.
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signals of a critical transition to
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R Wang et al
doi:10.1038/nature11655

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A Eulalio et al
doi:10.1038/nature11739
| miR-590miR-199a
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through octopamine and
dopamine in Drosophila
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doi:10.1038/nature11614
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doi:10.1038/nature11670

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M Brown et al
doi:10.1038/nature11657
.
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among coeval star clusters as
revealed by blue stragglers
F. Ferraro et al
doi:10.1038/nature11686

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interferometer
F Giazotto et al
doi:10.1038/nature11702

| 70
| 2013
A corotating plane of
dwarf galaxies orbits the
Andromeda galaxy, the
Milky Ways twin PAGES 31 & 62
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What to see and where

to be seen in 2013
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EPIDEMIOLOGY
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FIGHTS BACK
Drug resistance threatens
to undermine TB progess
PAGE 14
3 2013
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H Jiang et al
doi:10.1038/nature11732

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mantle and the extraction of
carbon from Earths interior
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doi:10.1038/nature11679

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the human gut microbiome
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doi:10.1038/nature11711
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dwarf galaxies orbiting the
Andromeda galaxy
R. Ibata et al
doi:10.1038/nature11717


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M Schultze et al
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G Retallack et al
doi:10.1038/nature11777
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B Haider et al
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E Barry et al
doi:10.1038/nature11693
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P Ohouo et al
doi:10.1038/nature11658

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F Alonzo et al
doi:10.1038/nature11724

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MOVING
MOUNTAINS
Glaciation primes an alpine

landscape for dramatic
response to climate
change PAGES 173 & 206
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How cutting-edge research

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AND WORSE
WHATS IN
?A WORD
Rare catastrophes that

could be the end of us
Small change to application

form is a game changer
PAGE 154
PAGE 159
10 2013
10
.

Quaternary
2.5

() .

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|
73 | 2 0 1 3

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to climate variations
preconditioned by evolving
topography
V Pedersen et al
doi:10.1038/nature11786

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mechanotransduction channel
subunit for gentle-touch
sensation
Z Yan et al
doi:10.1038/nature11685

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| 74
| 2013

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evolution of vertebrates
Y Oisi et al
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of cellulose synthesis and
membrane translocation
J Morgan et al
doi:10.1038/nature11744
doi:10.1038/nature11794
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primary binding site on the
insulin receptor
J Menting et al
doi:10.1038/nature11781


protostar

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protoplanetary gap
S Casassus et al
doi:10.1038/nature11769
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an ultraluminous stellar-mass
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M Middleton et al
doi:10.1038/nature11697

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W Fu et al
doi:10.1038/nature11690

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doi:10.1038/nature11727

180

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J Qin et al
doi:10.1038/nature11674

()
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M Knobloch et al
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differentiation by the long noncoding RNATINCR
M Kretz et al
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DNA
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separase-dependent removal of
the kleisin subunit of cohesin
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doi:10.1038/nature11630

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urea channel from the gastric
pathogen Helicobacter pylori
D Strugatsky et al
doi:10.1038/nature11684
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replication makes inverted
chromosome fusions at
inverted repeats
K Mizuno et al
doi:10.1038/nature11676


INSIGHT
Frontiers in
biology
NATURE.COM/NATURE
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Vol. 493, No. 7432
NANOSCALE MATERIALS
CULTURE
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PAGE 385
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Ultrahard cubic
boron nitride
Science at the Sundance

Film Festival
MENTAL HEALTH
FUKUSHIMA
LEGACY
Nuclear meltdown left

psychological scars
PAGE 290
17 2013
17
.

.

.

()

.
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of electronic wavefunctions in
real solids
G Booth et al
doi:10.1038/nature11770

( )ASDs
.
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)

.
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PAGE 424
Take
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dysregulated eIF4E-dependent
translational control
C Gkogkas et al
doi:10.1038/nature11628
)(
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.
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by the Indian Ocean
J Tierney et al
doi:10.1038/nature11785
|

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learning and memory
A Lee et al
doi:10.1038/nature11803
PKM- is not required for
hippocampal synaptic
plasticity, learning and memory
L Volk et al
doi:10.1038/nature11802
|
77 | 2 0 1 3
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boron nitride
Y Tian et al
doi:10.1038/nature11728
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| 78
| 2013
13
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doi:10.1038/nature11682
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inactivate the CRISPR/Cas
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J Bondy-Denomy et al
doi:10.1038/nature11723

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E Ruark et al
doi:10.1038/nature11725

.

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melt above the coremantle
boundary
C Herzberg et al
doi:10.1038/nature1177

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planktonic foraminifera
S Peters et al
doi:10.1038/nature11815
|

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J Muzerolle et al
doi:10.1038/nature11746

.
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binary stars
N Kaib et al
doi:10.1038/nature11780
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the initially transcribing RNA
polymerase IITFIIB complex
S Sainsbury et al
doi:10.1038/nature11715
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.
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.Nature
Nature :
arabicedition.nature.com

83 .

86 .

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SHUTTERSTOCK/SERGEY NIVENS
2012

.
.2012

.
:

.

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( 12900

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.

81 | 2 0 1 3

Academic
Medicine )S. E. Straus et al. Academic Med.
)http://doi.org/jzc; 2012

.
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. :
.
1. Doctorate Recipients from U.S. Universities: 2009
NSF 11-306 (National Science Foundation, 2010).
2. Wu, L. & Jing, W. Issues Sci. Technol. 28, 8287 (2011).
3. LEAP 2010 API Representation on Fortune 500
Boards (LEAP, 2010).
4. Asian American and Pacific Islander Work Group
Report to the Chair of the Equal Employment
Opportunity Commission (EEOC, 2008).
5. Report to the National Science Board on the National
Science Foundations Merit Review Process Fiscal
Year 2011 (National Science Foundation, 2012).

.
| 84
| 2013

..

Clostridium difficile

.

.

.
.

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:

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.

..
..
.

..

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|
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.
.

.
.

.

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.
..

.

. :
:
.
:
.
1. Sursock, A. et al. Trends 2010: A decade of
change in European Higher Education (EUA,
2010).
2. TRANS-DOC Survey on PhD Programme
Structures and Administration in Europe and
North America Presented 15 October 2012 in
Brussels; available at go.nature.com/sm6lp9.
3. OCarroll, C. et al. The PhD in Europe:
Developing a System of Doctoral Training
That Will Increase the Internationalisation of
Universities. In European Higher Education at the
Crossroads (eds Curaj,A., Scott, P., Vlasceanu, L.
& Wilson, L.) 461484 (Springer, 2012).
| 86
| 2013
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