Professional Documents
Culture Documents
INDUSTRIAL
PARTNERSHIPS
MARYLAND
INDUSTRIAL
PARTNERSHIPS
ISBN 978-0-9884803-0-8
Dedication
This book is dedicated to Dr. Herbert A.
Rabin and Dr. David F. Barbe, whose vision
and perseverance helped create and
sustain the Maryland Technology Enterprise
Institute (Mtech) and the Maryland Industrial
Partnerships (MIPS) Program.
©2012 Maryland Technology Enterprise Institute (Mtech), A. James Clark School of Engineering, University of Maryland
Foreword
Martin O’Malley, Governor, State of Maryland
The global challenges of our time—climate change, terrorism, scarce resources, is all happening while investing in our educational system, as every bit of MIPS funding
energy security, and healthcare—are driving a new wave of job-creating innovation goes to participating Maryland universities.
in education, technology and life sciences; all sectors for which Maryland has a strong
competitive advantage. To sustain job creation over the long term, a modern economy needs an engine that
continually drives advances in education and innovation. MIPS is one of those engines,
Therefore, the Maryland Industrial Partnerships, or MIPS, is critically important to we need it now more than ever.
Maryland’s ability to create jobs, expand opportunity, and make our children winners
in the changing global economy. Congratulations to MIPS for the advances it has supported for 25 years.
This book illustrates the broad reach of one of our State’s most successful initiatives for
fueling innovation-driven economic growth.
Over the past 25 years, more than 500 companies have utilized MIPS funding. They’ve
sold more than $24 billion in products and created thousands of jobs in Maryland.
1
2
Foreword
William E. Kirwan, Chancellor, University System of Maryland
Twenty-five years ago Dr. David Barbe, now Director of the University of Maryland’s member. This academic-industrial partnership in and of itself helps ensure both the
Technology Enterprise Institute, put forward a vision of a new program that would business viability of the idea and its technical feasibility.
leverage the resources of Maryland’s public universities to serve the future of the
state’s economy by bringing faculty and students into collaboration with Maryland Both the company and faculty member have incentives to participate and succeed. For
companies to develop new products and processes. As the then-president of the the company, there is access to world-class expertise and facilities, in addition to an
University of Maryland College Park, I was delighted to help this vision become a obvious financial incentive—funds for new, innovative product development. Faculty
reality as the Maryland Industrial Partnerships (MIPS) program. From the beginning, members get financial support for commercially directed R&D and their students have
the primary mission of MIPS has been to create the technology products that generate the opportunity to solve real world-problems in an entrepreneurial environment.
good jobs in our state, and MIPS has enabled the University System of Maryland (USM)
to do just that. This is the MIPS formula for success in innovating our way to the future. We take great
pride in the Maryland companies that have brought innovative products to market by
MIPS has blazed the trail in showing how effectively a relatively modest government- accessing the expertise of the creative faculty of Maryland’s public universities. I have
funded program can help us innovate our way to success. In the intervening twenty- no doubt that the MIPS program will see continued success in the future, providing
five years, Maryland companies have sold over $24 billion worth of products enabled even more economic growth and prosperity for Maryland.
by MIPS projects, highlighting the MIPS program’s ability to create thousands of good
jobs in our state. A new economic impact study by the Jacob France Institute of the
University of Baltimore shows that those MIPS products and the jobs they support
contribute $87 million each year in Maryland state taxes and another $70 million in
county taxes. This impact is accomplished with a budget that is currently less than $2 William E. “Brit” Kirwan
million per year, representing a substantial financial return to the State. Chancellor
University System of Maryland
The payoff from MIPS takes many other forms as well. Good paying jobs support
the high quality of life that defines Maryland and strengthens our communities. In
addition, the innovative products developed through MIPS make our state healthier
and more productive, as the pages of this book attest.
How has MIPS attained this remarkable success? The secret lies in the very structure
of the program. There must be a collaboration between a company and a faculty
3
4
A Remarkable Record of Success
The MIPS Economic Impact Study
We are very pleased to announce the recently completed economic impact study of • MIPS lifetime spending of $37.0 million assisted in catalyzing the development
the MIPS program: “An Analysis of the Impacts of MIPS Program Spending and the and commercialization of technologies that have attracted $884.2 million in
Commercialization of MIPS Funded Projects on the State of Maryland,” prepared by additional grant, debt, equity, and venture capital funding into Maryland.
Dr. Richard Clinch, Director of Economic Research at the Jacob France Institute of
the University of Baltimore. Dr. Clinch and his team analyzed the effects of the MIPS • Several MIPS supported companies have been acquired over the past few
program on Maryland’s economy and the return on the investment in MIPS to the years and the acquisition cost of these companies has totaled over $18.0 billion
state treasury. Some highlights of the 16-page report include: dollars.
• Research conducted by the MIPS program has found that MIPS supported Overall, the Jacob France Institute’s report paints a picture of a program that
technologies have generated $24.6 billion in cumulative sales over the past 25 continues to make a significant contribution to the Maryland economy.
years.
5
MIPS Projects Around the State of Maryland
Distribution of companies participating in MIPS projects around the state
Industries
Aerospace Engineering/R&D
AG/AQ/FOOD Manufacturing
Bioscience Medical
Map created by BNIA-JFI
Communications Software
Energy/Environment Other
6
Lockheed Martin
Stable photochromic compounds, shape memory alloys, and
coupled cavity lasers
Project Manager: Various; Principal Investigator: R. S. Hosmane, J. Baras, Y. J. Chen, UMBC, UMD
Location: Baltimore, Maryland - Baltimore County; Project Start Date: 2/1/1990
Business Description
Headquartered in Bethesda, Md., Lockheed Martin is a
global security and aerospace company that employs
about 120,000 people worldwide and is principally
engaged in the research, design, development,
manufacture, integration and sustainment of advanced
technology systems, products and services. The
corporation’s net sales for 2011 were $46.5 billion.
Challenge
Lockheed sought help from MIPS-supported researchers
to increase the stability of photochromic compounds, to
improve the quality assessment of shape memory alloys,
and to gain a better understanding of the operation of
coupled cavity lasers. Lockheed and Martin Marietta merged
in 1995.
MIPS Role
In the photochromic compound project, the university Interesting Fact
researchers fabricated samples of the materials and Lockheed and MIPS have collaborated on a total of eleven
performed chemical characterization of them. This research projects.
was published in a major scientific journal. For the shape
memory alloy project, university researchers developed
a prototype smart tool post for machine tools that can
self-tune to compensate for vibration during the cutting
process, resulting in a much smoother cut. In the laser
project, the university team designed and developed
a coupled cavity diode laser, which led to an improved
understanding of this type of laser.
7
8
Hughes Network Systems
Broadband Internet applications over satellite
Business Description MIPS Role “Dr. Hansen and MIPS were essential to
20/20 GeneSystems (‘20/20’) was founded in May, 2000, Hansen had a deep background in relevant biochemistry
to develop and promote an innovative proteomics and had previously invented chemical agents to the success of this product, which has
product line that provides drug companies, biodefense kill anthrax spores, so he was quite expert in the become an international gold standard
specialists and life scientists with new tools for protein environment in which the test kits would be employed.
analysis. The company’s headquarters are in the heart He made specific recommendations on improvements
for suspicious powder screening. Over
of the biotechnology corridor in Rockville, Md., in close to and the optimization of BioCheck®, and ran many tests the past seven years, thousands of
proximity to the National Institutes of Health with which demonstrating its efficacy compared to generic protein government and commercial places
the company has extensive collaborations. tests.
of businesses have been able to safely
Challenge Results and promptly resume operations
20/20 was developing the BioCheck® Suspicious Powder 20/20 GeneSystems has formed a separate division,
Screening Kit, which provides a cost-effective, reliable 20/20 BioResponse, to produce, market and sell following suspicious powder incidents
screening tool to quickly and easily determine whether a BioCheck®. In 2010, Smiths Detection began distributing through the use of this product by
powder contains biological material in order to rule out the product worldwide.
many of the substances that cause powder incidents (e.g.
first responders. BioCheck® has likely
talcum powder, dry wall dust, powdered sugar, etc.). The saved hundreds of millions of dollars in
company needed researchers to improve, optimize, and economic waste while creating many
test the effectiveness of the product.
new jobs in Maryland.”
– Jonathan Cohen, President and CEO,
20/20 BioResponse
11
12
A&G Pharmaceutical
Breast cancer theranostic biomarker
Project Manager: Ginette Serrero, Ph.D.; Principal Investigator: Katherine Tkaczuk, M.D., UMB
Location: Columbia, Maryland - Howard County; Project Start Date: 8/1/2008
13
“I can see the benefits and the
strengths of having Maryland
companies working with University of
Maryland faculty. The MIPS program
was very useful and powerful in
getting it [GP88] to the next level.”
– Dr. Ginette Serrero,
CEO, A&G Pharmaceutical
14
Advanced Digital Forensic Solutions
Image classification technology for forensic triage
“The MIPS project was a success in that Business Description During the MIPS project, researchers collaborated with
ADF Solutions is the market leader in media exploitation ADF to perfect one image classification technology and
it provided us with a state of the art and cyber forensic triage tools used for scanning integrated several iterations into the company’s tools.
image analysis technology, which was computers and peripheral devices. These easy-to-use
tools rapidly extract actionable intelligence to help The resulting image classification technology provided
primarily aimed at our law enforcement identify and capture suspects who are a threat to public ADF with a whole new way to quickly identify
users.” safety or national security, and accelerate prosecution of incriminating data by classifying suspect pictures into
criminals. These proven tools are actively used by field categories of interests, saving agents time by not having
– J.J. Wallia, CEO,
Advanced Digital Forensic Solutions, Inc. operatives in defense, intelligence, law enforcement, to review every single picture.
border security, and other government agencies
worldwide. Results
The project successfully produced an advanced image
Challenge analysis technology.
ADF sought technologies that could identify
incriminating data faster and more accurately.
MIPS Role
UMD researchers were already working on advanced
image classification technologies that were deemed a
perfect fit for ADF’s tools.
15
16
AHPharma Food Safety Products
Radiant floor heating and LED lighting for poultry houses
Project Manager: James L. McNaughton, Ph.D.; Principal Investigator: Jeannine Harter-Dennis, Ph.D., UMES
Location: Salisbury, Maryland - Wicomico County; Project Start Date: 8/1/2012, 4/20/2010, 8/1/2008
17
“AHPharma has been impressed
with the professionalism of the MIPS
technical personnel, as well as with
the university specialists, in assisting us
in the commercialization of this new
technology.”
– James McNaughton, President and CEO,
AHPharma
“MIPS provides an avenue for the poultry industry to get on a path of sustainable
agriculture, produce energy savings that result in quick payback and significant
grower profits, provide technology needed to meet EPA regulations to have a
positive impact on Chesapeake Bay Restoration, and providing a much needed
boost in the Maryland jobs market, not only in the manufacturing of new technology
systems, but in the marketing, installation, and maintenance of these systems as well.”
– James McNaughton, President and CEO, AHPharma
18
Alertus Technologies
Emergency alert messaging system
Business Description the technology would need to be optimized and MIPS project ended, Alertus received funding from an
Alertus Technologies has a decade of experience in prototyped. NCIIA grant, business plan competitions, and TEDCO
developing emergency alert systems for campuses grants to bring the invention to market.
and large-area, high-occupancy facilities. The Alertus MIPS Role
Emergency Notification System is designed to cost- Through MIPS, Alertus Technologies completed a Several key member’s of Alertus’ team were participants
effectively retrofit in-building spaces through innovative prototype of the company’s Alert Beacon® and validated of the university’s Hinman CEOs Program, the nation’s
technologies such as the Alert Beacon®, while leveraging the system’s radio subcarrier technology. first undergraduate living-learning entrepreneurship
and integrating existing facility infrastructure and IT initiative. Blake Robertson, CTO, connected with Jason in
assets. The outcome is a single, integrated “easy button” Results 2003 while both were in Hinman.
alerting capability to ensure timely, consistent notifications Alertus Technologies now has 20 employees, multi-
to everyone enterprise-wide. Alertus is recognized million dollar revenue, and a continually expanding FEMA partnered with Alertus during the past few years
worldwide for its unparalleled reliability, affordability, and product line. The company has hundreds of customers, on its initiative to create a next-generation national
interoperability. The company’s clients can attest to the including the U.S. Capitol and other government Integrated Public Alert Warning System. Alertus was
reliability of the Alertus solution, having activated the facilities, universities and schools, medical centers, awarded a contract for the study and testing of its radio
system during real emergencies and threats to save lives, military bases, and commercial facilities. Alertus’ subcarrier technology and has assisted in other areas
protect property, and maintain continuity of operations. products are distributed by Honeywell Fire Systems and such as alerting individuals with disabilities.
serve as a receiving device for WeatherBug’s lightning
Challenge detection stations in school systems and airports
In 2001, a tornado ripped through the University of across the country. Alertus Technologies has developed “MIPS funding was pivotal. It enabled us to
Maryland, tragically killing two students and injuring additional products related to its Alert Beacon®, validate the invention’s commercialization
others. Unfortunately, like most campuses, the including a text-to-speech interface for public address
(PA) systems, digital signage override software, Alertus
potential and get onto the path to our first
buildings did not have a public address system. Alertus
Technologies was founded by a university student, Jason Desktop for computer networks, cable TV override, LED customers. Without MIPS, we would not
Volk (’03, MBA ’05), then 19 years old, with an innovative marquees, VOIP alerts, and a fire alarm interface. have been able to get our first product
idea for equipping campuses with prominently placed,
wall-mounted, audible-visual notification appliances Interesting Facts out the door and land those first few key
using a reliable, cost-effective transmission medium, Alertus Technologies was the first student-formed customers.”
FM radio data subcarriers. To put the idea into practice, company to receive MIPS funding. Just as the company’s
– Jason Volk, CEO, Alertus Technologies
19
Alertus Technologies’ wall-
mounted Alert Beacon® captures
the attention of building
occupants with flashing strobes
and a sounder, and notifies
what the emergency is and
how to respond. The units are
typically mounted in lobbies
and prominent areas as a cost
effective solution to equip multi-
building facilities with reliable
emergency notification in the
absence of a conventional public
address system. Alert Beacons®
are today installed in hundreds
of campuses and other facilities.
20
American Dynamics Flight Systems
Vertical take off and landing unmanned aerial vehicle
21
“MIPS allowed us to push our technology forward,
and we wouldn’t be anywhere near the maturity
of our technology if it wasn’t for MIPS.”
– Wayne Morse, President and CEO,
American Dynamics Flight Systems
22
Amplimmune
Testing cancer therapeutic AMP-224 for enhanced immune response
23
24
AnthroTronix
Robot toolkit for rehabilitation
Project Manager: Corinna Lathan; Principal Investigator: Catherine Plaisant and Allison Druin, UMD
Location: Silver Spring, Maryland - Montgomery County; Project Start Date: 2/1/2001
25
“MIPS provided us with a great opportunity
to work with cutting-edge researchers and
was core to our ability to develop products
for kids with disabilities.”
– Corinna Lathan
Board Chair and CEO, AnthroTronix
26
Automated Precision
Algorithms and software for 3D inspection system
Business Description The images are taken while specialized light patterns
For 25 years Automated Precision, Inc. (API) has been are being projected on the object using a computer
creating advanced metrology solutions for the world’s projector. Images and light patterns are analyzed “We thought, ‘why limit yourself to one light pattern’?”
leading companies. API offers a unique mix of innovative together through a new algorithm developed by Dr. said Gupta. “By using multiple patterns, we can
engineering capability, superior product quality, and Gupta and Tao Peng, a Ph.D. student in the department accurately analyze holes and discontinuities in
outstanding customer service to improve businesses. of mechanical engineering. The 3D models are then surfaces—within seconds.”
The API team can significantly improve the quality of examined against specifications for a particular product.
products and processes. Not only do their experts enhance Results
a company’s ability to perform inspections, but they also Systems using single light patterns are also used today, The project enabled API to further develop and
enhance the capability of the machines producing parts. but with limitations. If parts have holes or discontinuities, expand the market for its family of laser 3D coordinate
API shows companies new ways of increasing productivity, they can fail. measuring machines. The company has added 72 jobs
reducing scrap, enhancing machine accuracy, and and annual revenues of $29M.
improving inspection efficiency.
MIPS-Related Quotes
Challenge “One out of every 200 automobiles might be sampled
API sought to develop algorithms and software for on a car production line,” said Aaron Sabino, Product
3D inspection using point cloud data after being Manager for API. “It can take 12-18 hours to inspect a
approached by an automobile manufacturer to solve a vehicle. Hundreds of cars can go through during this
part-scanning problem. time.”
MIPS Role
UMD researchers helped develop the core of API’s
RapidScan technology, which scans but does not touch
products. Instead, it takes images using a digital camera
and creates 3D computer models from those images.
27
API connected with the
university after Peng
interned at the company.
API was approached by an
automobile manufacturer
to solve a part-scanning
problem.
28
AviHome
Plenum floor ventilation for poultry houses
29
Darkling beetles are also a menace for
the broiler industry. They are a major
vector for disease while also damaging
to poultry houses and food safety. No
darkling beetles were found in the
AviHome system trials.
30
Baltimore Animal Medicine
Slow-release analgesic for veterinary medicine
31
MIPS “helped make this happen.”
– Michael Guarnieri, CEO,
Baltimore Animal Medicine
32
Beacon Research
Stormwater filtration system
Project Manager: David M. Ayres; Principal Investigator: Allen Davis, Ahmet Aydilek, UMD
Location: Columbia, Maryland - Howard County; Project Start Date: 2/1/2012
Business Description particular importance in the Chesapeake Bay watershed, the laboratory-scale research into working prototypes
Beacon Research is a research and development firm as particulate matter may include nitrogen and for testing in urban environments. Although the research
focused on environmental remediation research, clean phosphorus-containing matter. These two nutrients, in conducted in Dr. Allen Davis’ laboratory in the University
water technology and rapid prototyping. addition to sediment, are the primary pollutants of the of Maryland’s department of civil and environmental
Chesapeake Bay. engineering proved the validity of the technology, the
Challenge applied science had not yet been proven. The MIPS
Our current urban infrastructure is highly reliant on The premise for this work is that commercial synthetic funding is assisting BRI as the company builds and tests
impervious surfaces, including roadways, parking lots, filter and drain elements, namely geosynthetics, can multiple prototypes. The project team is examining the
and building rooftops. Rainfall that strikes these surfaces be used as filters to remove particulate matter from economy of design and replacement of geotextile filters
cannot infiltrate into the soil and subsurface, rapidly urban runoff and that the resulting technology will have within stormdrains and their performance under varying
becoming surface runoff. This runoff is conveyed away several advantages over existing stormwater control environmental conditions.
from the source via the stormdrain infrastructure system technologies. Fundamental laboratory work to date has
to minimize flooding and associated safety concerns. demonstrated that geosynthetic filters can effectively Results
As this rainfall and runoff is transported across these remove suspended solids from urban runoff through While this project is underway, BRI’s range of prototypes
impervious surfaces, particulate matter is mobilized a filtration mechanism, improving water quality; and has been designed and constructed and are awaiting
and transported. These particulates include soil matter provide uniform flow and thereby increase the drainage approval from the University of Maryland and Howard
and anthropogenic particulate matter resulting from capacity of the drain system. Geosynthetics can provide County to insert in optimal locations for testing. Once
the attrition of pavements, vehicle wear materials, and a simple treatment system and/or replace traditional field-testing is complete, the product is slated for a
corroded building materials. These enhanced flows and sand filters in stormwater runoff treatment systems in launch in late 2013.
particulate loads are directed into local receiving bodies, urban areas, while minimizing the need for cleaning or
causing erosion problems, toxicity concerns, and general material replacement. These filters may also have other
overall detriment to stream ecosystems. Currently, most filtration applications for water quality improvements.
urban storm drains have no or inefficient treatment.
An efficient technology to address stormwater quality MIPS Role
in highly urbanized areas could have a major impact The grant from MIPS and the Maryland Department of
in managing runoff in these areas. This issue is of Natural Resources enabled Beacon Research to transfer
33
“MIPS allows small companies
like ours to tap into the brightest
minds and the best talent within
the University of Maryland
system as we tackle the most
challenging problems of cleaning
the Chesapeake Bay. With our
MIPS-DNR grant, we were able to
leverage our strength in design
and rapid prototyping with
the academic strengths of the
University.”
– David M Ayres, Principal Scientist, BRI
34
Beyond Meat
Taste and product enhancement for plant protein (meat alternative) products
Business Description on the entire bike. The transmission gears also had to
BIKETOO Inc. was founded in 2002 by Phil Adkins, Drew be thoroughly tested and analyzed for the possibility
of selecting better materials for the gears. In addition, Pictured, from left to right: Dinesh Agarwal, Andy Phillips, Drew Phillips, Phil
Phillips, and Andy Phillips. The company is developing
Adkins and Norman Conway.
Biketoo®, a patented, multi-speed, motor-driven cycle the transmission housing had to be redesigned to help
that allows riders to use only pedals and/or a motor, reduce the weight of the bike and reduce production
and uses gasoline or propane as its power source. The costs. Drew Phillips invented the bike after considering
49 cubic centimeter motor is California EPA-approved.
MIPS Role the biggest problem with bicycling for long
Shifting between pedal and gas/propane motor modes
is very easy, using a patented “kick-out”. The bike While the project is still in progress, the bike’s vibration distances— you always needed to select a point
features zero drag from the power drive-train when in and stress tests have “passed with flying colors.” UMD to turn around so you were not too tired to return
pedal mode. engineers have reduced the transmission housing
home. His goal was to create a bike that you
weight by six pounds, with further reductions likely.
Challenge They are currently working on the final set of gears. could pedal until you are ready to drop, and then
BIKETOO needed vibration and stress tests conducted flip a switch to the power mode and comfortably
Results ride home at speeds up to 30 MPH. It took the
BIKETOO has found vendors for 75 percent of its bike
parts, including the MIPS team-specified components.
company three years to build its prototype. The
All meet DOT or EPA specifications where required, bike has multiple patents that cover the engine
including the tires, rims, brakes, and lights. When location in relation to the frame structure, and
customers purchase the bike they can select from either
drive line design, among others.
of two motors: gasoline or propane.
37
“Without MIPS, we would have
had little chance to get this bike in
production. The work they are doing
for us would have cost us upwards of
$250,000.”
– Phil Adkins, CFO, BIKETOO
38
Biomedica Management
Optimization of blood-clotting foam to treat severe bleeding
MIPS Role
The company is working with Dr. Leonid Medved from
the UMB department of biochemistry and molecular
biology to test the hemostatic efficiency of the ClotBlock
fibrin layer and the optimal amount of thrombin for
preparation of the ClotBlock thrombin layer.
39
40
BioSurface Engineering Technologies
Spinal fusion using a novel peptide
Business Description used the results to design an optimal drill bit that
Since 1910, Black & Decker has been setting the standard significantly improves the performance of percussion
for innovation and design of power tools, accessories, drilling. The new bit has improved energy transmission,
outdoor yard care equipment, home cleaning products, a better material egress mechanism, and enables
automotive and lighting products, hardware and other environmentally safe operation.
home improvement products. The inventor of the first
portable electric drill with pistol grip and trigger switch, The work included developing an impact model based
Black & Decker has evolved from a small machine shop on 3-dimensional wave propagation, an experimental
in Baltimore, Maryland to a global manufacturing and facility to validate the egress model, a combined egress
marketing powerhouse with a broad line of quality and impact model, and optimal drill bit design. The
products used for home and commercial applications. project also included the fabrication of a prototype drill
When users need to get work done, they trust Black & bit.
Decker for the products that will do the job efficiently and
reliably. Results
A new line of 29 drill bits, called Bullet Speed Tip
Challenge Masonry Drill Bit, resulted from the project, leading to
Black & Decker sought to design a family of masonry annual sales of several million dollars. The Bullet bits drill
drill bits with improved efficiency to conserve power in up to two times faster than competitive bits, and drill up
battery-powered drills. to six times more holes per battery charge when using a
cordless drill. Patents were issued to UMBC and licensed
MIPS Role to Black & Decker.
UMBC researchers conducted a systematic, scientific
Black & Decker merged with Stanley in study of the mechanics of concrete drilling and
2010 to form Stanley Black & Decker.
43
44
Blackrock Algae
Biofouling screen systems for improving water quality in the Bay
Project Manager: Matthew J. Diedzic, Jr. “Jay”; Principal Investigator: Patrick Kangas, UMD
Location: Perry Hall, Maryland - Baltimore County; Project Start Date: 2/1/2011
45
The Chesapeake Algae Project (ChAP), which was initiated by and
is currently managed by parent company Blackrock Energy, is a
partnership of higher-education institutions and corporations through
a multilateral agreement comprised of: the University of Maryland,
College Park, College of William & Mary, Virginia Institute for Marine
Science, Smithsonian Institution, University of Arkansas, Western
Michigan University, Statoil, HydroMentia, and the Blackrock Energy
Corporation. 46
Blue Infusion Technologies
Bluetooth glove for controlling smartphones
Project Manager: Willie L. Blount Jr; Principal Investigator: Marc Cohen, UMD
Location: Columbia, Maryland - Howard County; Project Start Date: 8/1/2012
They include wafer heater products, thin film and Blue Wave’s products are sold to U.S. research
coating services, and chemical and physical vapor institutions. The company is planning commercialization
deposition products. and full-scale manufacturing for its products.
Challenge Blue Wave has developed its own technology and has
Blue Wave sought to develop new thin film and oxide several U.S. patents.
coatings for the company’s line of semiconductors.
MIPS Role
The university team developed highly sensitive UV
detectors for chemical and biological sensing, missile
49
“MIPS support was the
foundation for this company.”
– Dr. R.D. Vispute, CEO & CTO,
Blue Wave Semiconductor
50
Bowles Fluidics
Fluidic nozzle for windshield wipers testing and development
51
“The aerodynamic effects on
performance of windshield washer
systems have helped us develop
systems to meet our customer
requirements.”
– Chi Srinath, V.P. Advanced Engineering,
Bowles Fluidics
52
Captain’s Choice Food Products
Food processing line for seafood soups
53
Captain’s Choice is a new spin-off venture of Beach to Bay Seafood, Inc. Beach to Bay is a family
owned and operated seafood restaurant and market with more than 30 years of retail experience.
They have a retail store in the restaurant where they sell their very popular marinades, seasonings,
fresh crab soups and clam chowder. Beach to Bay is owned by Richard Evanusa and his family. They
previously owned and operated a successful seafood business —Beachy’s Seafood—in Ocean City,
Maryland for 10 years. Beach to Bay relocated to Princess Anne as the need to expand exceeded
their Ocean City location. Prior to that, they operated Leon’s Delicatessen and Catering in Salisbury,
Maryland, for over 20 years.
54
Cellex
Rapid and sensitive flu test
Cellex will also apply for FDA Business Description value and for determining the preliminary sensitivity
Cellex develops technologies and products for and specificity for the QFlu test. Mutations as identified
approval for the second product, the diagnostic tests suitable for point-of-care use. by sequencing were used as a gold standard for drug
QFlu Diagnostic Test, which is intend- resistance.
Challenge
ed to be used for influenza diagnosis. Cellex sought a clinical study of the company’s rapid, Results
They intend to submit this application point-of-care method for diagnosing influenza and flu The MIPS grant funding enabled Cellex to gather clinical
data, which helped the company get a $2 million NIH
in the next two weeks and could get virus drug resistance.
grant, which in turn permitted them to perform a large
approval by late December 2012. MIPS Role clinical study enrolling more than 500 patients. The data
A clinical study was conducted for Cellex’s QFLU, a test from the MIPS and NIH-funded studies was submitted
designed to simultaneously diagnose influenza and to the FDA in September, 2012, in an application for
detect flu virus drug resistance in point-of-care settings. approval for Cellex’s first product, the QFlu Combo Test,
The clinical study involved three clinics and enrolled which can be used to simultaneously diagnose influenza
several hundred voluntary patients. Two nasophyrangeal and detect resistance to Tamiflu. This is a first-of-its-
swabs were collected from each participant. One of the kind product that has great commercial potential and
swabs was used for culture-based detection, while the significant public health implications. Cellex is confident
other was used for QFLU test-based detection. The cell it can be approved by the FDA in 6-9 months.
culture method is a gold standard for setting a cutoff
55
“The MIPS grants have played an
important role in bringing the QFlu
project to a successful conclusion.”
– Dr. X. James Li,
Chief Scientific Officer, Cellex
56
Coil
Active cables for electric guitars
58
Corridor Pharmaceuticals
Therapeutic for anthrax and other pathogens
Project Manager: Peter D. Suzdak, Ph.D.; Principal Investigator: Gerald Rosen, UMB
Location: Towson, Maryland - Baltimore County; Project Start Date: 2/1/2012
59
60
CSA Medical
Spray cryotherapy for esophageal cancer
Project Manager: Steven . Schaefer; Principal Investigator: Bruce D. Greenwald, M.D., UMB
Location: Baltimore, Maryland - Baltimore City; Project Start Date: 2/1/2012
61
“Years ago, CSA medical
was able to attract
several million dollars of
investment capital. But
it wasn’t until Maryland
Industrial Partnerships
came along, and in
particular with the
support of Dr. Martha
Connolly, that we were
able to take it to the
next level and attract
additional capital and
do additional studies to
prove the efficacy of the
technology.”
– Steven E. Schaefer
Chief Financial Officer,
CSA Medical
62
DataStream Content Solutions
Content management user interface and software engineering best practices
63
64
Earth Networks
Thermodynamic models for a home energy demand response system
Business Description for utilities, helping them to reduce demand for power
As a provider of comprehensive atmospheric data for nearly during peak times by pre-heating and pre-cooling
20 years, Earth Networks is taking the pulse of the planet buildings and tying into their smart grid initiatives.
with the world’s largest weather observation, lightning
MIPS Role “We are fortunate to work with a great
detection, and greenhouse gas monitoring networks
and is establishing a network for collecting data within Mechanical engineering professor Jungho Kim and mechanical engineering group at the
the planetary boundary layer. The company’s popular doctoral student Michael Siemann developed the University of Maryland…MIPS funding
WeatherBug website, desktop application and mobile thermodynamic models Earth Networks uses in e5 to allowed us to get into the market using
apps for major smartphone platforms provide real-time, predict energy consumption based upon weather data. a novel approach to demand response
neighborhood-level weather and advanced severe weather That data is compiled from Earth Networks’ 10,000 challenges. Once we have data certified
alerts to millions of consumers. Enterprise solutions weather stations, each of which sends information
by utilities and consumers like us, we are
from Earth Networks enable organizations and markets, every 2.5 seconds, along with input from the company’s
staff meteorologists and data from both the National
expecting to grow the program into a
including energy and utilities, agriculture, schools, sports
and recreation, emergency operations and government Weather Service and World Meteorological Organization. much larger initiative that will hopefully
entities, to safeguard lives, prepare for weather and The UMD team’s model takes all of this data, predicts result in more skilled and well-paying
climate events and improve business operations. Founded the temperature inside a building and calculates the jobs here in Maryland. MIPS funding was
in 1993, Earth Networks (www.earthnetworks.com) is energy it will take to maintain it. That information is critical in getting the e5 program from
headquartered in Germantown, Md., with additional then used to pre-cool or pre-heat a structure to reduce
concept to reality.”
locations in Mountain View, Calif.; New York, NY; Milan, Italy loads during peak times, saving both utility companies
and a local presence in 50 countries worldwide. and consumers money while keeping temperatures – Christopher D. Sloop, Chief Technology
comfortable. Officer and Co-Founder, Earth Networks
Challenge
Earth Networks developed and piloted a new home Results
energy efficiency demand response program called e5, Earth Networks began e5 pilot programs with utility demand-response events. Overall, the e5 program resulted
which stands for ease, energy, efficiency, environment companies and consumers in Texas during the summer of in an average energy savings of 13.8% when thermostat
and Earth. The service works for consumers as a free 2012. The e5 pilot program demonstrated impressive results setbacks were optimized.
smart app for their thermostat that helps them manage when compared to traditional thermostat-based demand
their heating and cooling. The e5 service also works response programs. In fact, the e5 program kept homes, on
average, within 1.5 °F of the users’ comfort settings during
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Earth Networks’ president and CEO Robert
Marshall, who also co-founded the company in
1993, is a cum laude graduate of the University
of Maryland College of Engineering (UMBC). The
company supported the work of Kim, Siemann,
and Greg Smith on e5 for two years prior to the
MIPS project, at $80,000 per year.
66
EcoEmergence
Efficacy test for bioremediation products on fats, oil and grease in wastewater
67
68
Emerald Sky Technologies
H-OZ , collaborative autopilot inner loop controller
Project Manager: Steven L. Fritz; Principal Investigator: James (Sean) Humbert, UMD
Location: Columbia, Maryland - Howard County; Project Start Date: 2/1/2010
Business Description executing a flight with maximal safety and efficiency. Emerald Sky Technologies originated
Emerald Sky Technologies (eSky) develops advanced The MIPS project supported development of the inner
avionics for general aviation. The company’s products loop controller (ILC) for H/OZ at UMD. The ILC accepts in the MCE Incubator (formerly the
are based on OZ, an integrated graphical primary flight commands and sensor data from H/OZ and sends control NeoTech Incubator) in Howard County.
display system and HFCS, a collaborative flight control inputs (bank angle, pitch attitude, power) to the aircraft
system. to maintain the selected flight parameters.
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70
Epitaxial Technologies
Epitaxial material characterization
Project Manager: Dr. Olaleye Aina; Principal Investigator: Terrance L. Worchesky, UMBC
Location: Baltimore, Maryland - Baltimore County; Project Start Date: 2/1/1999
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72
FiberCell Systems
Validation of a large-scale, hollow fiber bioreactor
Business Description performance. This would be an entirely new concept in Dr. George Pavlakis at the NCI in
FiberCell Systems is a leading supplier of hollow bioreactor operating principles.
fiber bioreactors to academic and biotechnology Frederick provided FiberCell with the
markets. Hollow fiber bioreactors offer many MIPS Role cell line to test for protein production.
significant advantages over conventional cell culture MIPS supported the building of the prototype, but also
methods. The adoption of hollow fiber bioreactors for connected FiberCell Systems with Dr. Dean Mann at
If successful, it will be the first time
biomanufacturing has been limited due to the fact that UMB, Dr. Paul Allenza and his BREP group in Mtech’s that this protein has been available
Biopharmaceutical Advancement Facility (BAF). BAF
a scalable system has not been available. Current hollow
provided laboratory space, equipment, facilities and
in significant quantities for animal
fiber systems are limited by the solubility of oxygen in
cell culture media and the pumps required to generate expertise to make the project possible. The combined testing. The only method that has
high flow rates. role of MIPS, UMB and BAF was instrumental in making worked for production of this protein
the project happen.
Challenge is in FiberCell’s smaller scale hollow
FiberCell Systems developed and patented a novel Results fiber bioreactors. A direct comparison
method for generating gas delivery to hollow fiber Proof of principle for the basic function of the
cartridges. Instead of passively exchanging gas with bioreactor operating principles was established. Further
with the large-scale system provides
a medium and flowing that medium through the optimization of culture conditions and operating valuable information about the scale-
parameters with an ultimate goal of establishing cGMP
cartridge, it delivers alternating amounts of medium
compliance is ongoing.
up process. This is a further example
and gas directly to the interior of the reactor. Rather
than using pumps, gravity feed is utilized to circulate of the strength of collaboration for
the medium in both directions. The challenge was to biotechnology research in Maryland.
create and build a prototype system and evaluate its
73
“MIPS provided FiberCell with both
the seed money to test and evaluate
a new type of bioreactor and
connections with Maryland resources
to make the project a success.”
– John Cadwell, President, FiberCell
74
Fleetpro
Training for vehicle inspection
Business Description in the late 80’s. Towson provided a professor of and Accessories Necessary for Safe Operation
Fleetpro provides on-site preventive maintenance and instructional course development, while Fleetpro • FHWA Appendix G Minimum Periodic Inspection
inspection services for vehicle and equipment fleets. provided subject matter experts. This effort resulted Standards
Currently over 14,000 vehicles, operated by 300 fleet in initial training programs for basic preventive
• FHWA Part 396 Inspection, Repair and Maintenance
customers, utilize Fleetpro’s services in the Mid-Atlantic maintenance and company policy and procedures. This
region. Fleetpro customers include private commercial/ was followed several years later, in 1994, by a second, • Code of Maryland Regulation 11.22 Preventive
industrial business fleets, as well as municipal, local, larger MIPS project between University of Maryland Maintenance Program
state and federal government fleets. These fleets contain University College (UMUC) and Fleetpro. This multi- • Commercial Vehicle Safety Alliance (CVSA) Out of
the full range of commercial vehicles, including trucks, year, multi-phase project was to develop a series of five Service Standards
tractors, transit buses, school buses, autos, and off-road paper-based, self-instruction training programs and
equipment, among others. certification exams incorporating Instructional Systems The training programs have dramatically improved how
Design methodologies. UMUC provided multiple experts commercial trucking companies, transit agencies, school
Challenge in ISD, who worked with a team of Fleetpro and outside bus operators, and other commercial and government
Fleetpro management recognized the importance of subject matter experts. fleet users have their vehicles inspected for compliance
professional training programs to provide reliable and with state and federal preventive maintenance and
efficient vehicle inspections that would comply with Results safety laws. The programs and training materials
federal and state regulations. At the time, a survey of Fleetpro has increased its revenues over 800 percent developed via the MIPS projects are still in use today and
the training market showed there were no regulatory, since these programs were instituted, from just under will continue to be.
inspection-focused training programs commercially $1M in revenue at the start of the MIPS projects, to over
available. Fleetpro decided to develop and implement $8M today. More than 400 people have been trained
a set of training programs to meet the need. After using Fleetpro programs.
researching the training program development market,
the company realized the complexity of such projects The 1994 MIPS multi-year project resulted in the
and that they needed the assistance of professional development of the five programs covering the
educational program developers. following vehicle inspection related federal and state
regulations and standards:
MIPS Role
Fleetpro’s MIPS project began with Towson University • Federal Highway Administration (FHWA) Part 393 Parts
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“Fleetpro has a very comprehensive regulatory and preventive
maintenance training program. After training, technicians are
able to produce a much more reliable and consistent, standards-
based inspection than ever before. This results in safer vehicles
and lower costs of fleet operation and maintenance.”
– Bill Nielson, Fleet Maintenance Manager,
Fleetpro
76
FlexEl
Battery management system for thin-film batteries
77
FlexEl is a UMD spinoff based upon the work of
electrical and computer engineering professors Martin
Peckerar and Neil Goldsman. The pair developed
FlexEl’s batteries when investigating a new way to
power “Smart Dust” through a government grant.
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Fyodor Biotechnologies
Yeast-based Artemisinin (YAT) Production
Business Description method, and is thus able to meet and adjust to market
Founded in 2008, Fyodor Biotechnologies is focused demands.
on the research, development and manufacturing of
innovative diagnostic and biopharmaceutical products MIPS Role
targeted towards global health diseases. Fyodor Fyodor worked with Dr. Ganesh Sriram from the
is a socially responsible company focused on the University of Maryland’s department of chemical and
translation of relevant biotechnologies to diagnostic and biomolecular engineering to develop and optimize this
biopharmaceutical products, designed to address critical novel, yeast-based technology to reliably produce and
healthcare needs in emerging markets in Africa, Asia manufacture artemisinin. The project demonstrated that
and South America. The company’s goal is to expand the YAT technology can produce artemisinin in yeast
the availability and affordability of rapid diagnostics at least 1,000 times more efficiently and faster than the
and pharmaceuticals, with an initial focus on malaria. conventional plant source.
Fyodor’s flagship product is the Urine Malaria Test—a
one-step test for at-home or point-of-need diagnosis of Results
clinical malaria in persons with fever. Fyodor won two SBIR Phase I awards (each worth
$150,000), a $476,000 SBIR Phase 2 award, and a $200,00
Dr. Eddy Agbo was a Research Fellow Challenge commercialization funding award from the Maryland
at the Johns Hopkins University School The drug Artemisinin is, to date, the most effective Biotechnology Center. The company is located in the
treatment against malaria and is in clinical trials for University of Maryland, Baltimore Biopark, having
of Medicine, where he worked on the treatment of other diseases as well. Artemisinin is recently expanded their laboratory space.
diagnostic and therapeutic biomarker extracted from plants with long growing seasons, often
resulting in low crop yields, which lead to shortages and
discovery, then went on to work in supply interruptions. Fyodor’s YAT platform technology
industry before founding Fyodor. is based on an industrial process for artemisinin
synthesis, which shifts artemisinin production from
plants to a more reliable and scalable, yeast-based
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80
Genovation Cars
Aerodynamic modeling of a high-efficiency automobile
Business Description
Rockville, Md.-based Genovation Cars Inc designs and
builds pure electric vehicles (EVs) and plug-in hybrid
electric vehicles (PHEVs). The company is currently
developing the G2; a two-door, four-seat, hatchback
PHEV with an electric-only range of 50 miles and 300-
mile capability with a range-extending generator.
The G2 is designed for simplicity, safety, low-cost
manufacturing and off-the-shelf availability of parts
made in America. The company’s objective is to provide
its customers with safe, sustainable automobiles that do
not compromise their driving independence or pleasure.
Challenge
A major challenge when designing any fuel-efficient
vehicle is minimizing aerodynamic drag while
maintaining a style that is attractive to buyers.
Predicting the drag coefficient using computer
simulation is standard procedure, but wind tunnel
testing is essential to ensure stability under various pitch
and yaw situations. The results of these tests provide
essential data to vehicle suspension designers.
data contributes enormously to future passenger safety, giving the company confidence in using the model for
MIPS Role which is worth much more than fuel savings. future design modifications. More importantly, the large
The Glenn L. Martin Wind Tunnel is perfectly suited to data set produced through testing can be used by the
testing vehicles. A small business such as Genovation Results suspension design team and eliminate trial-and-error
Cars could not afford the cost of privately contracting Tests demonstrated that the original computational design in the future.
with a commercial wind tunnel to run these tests. The fluid dynamics modeling was accurate and reliable,
81
“The MIPS program enabled Genovation to achieve a critical success factor in the most cost-
effective means possible. One of the biggest aspects related to automobile efficiency is air
resistance. Typically, around 60 percent of the power required to cruise at highway speeds is used to
overcome aerodynamic drag. This percentage increases significantly the faster you go. Automotive
aerodynamics is also critically important for safety reasons, most notably to increase downforce. Great
care was taken to design the G2 with a healthy amount of downforce and aerodynamic stability.”
– Andrew Saul, CEO, Genovation Cars
82
Gliknik
Recombinant IgG Fc for treatment of autoimmunity
Challenge
GlycoPure sought to modify an existing, proprietary,
cell-based method for converting chitin to
n-acetylglucosamine (NAG) to effectively produce NAG, a
high-value chemical precursor to glucosamine.
Chitin is extracted from crab and other
MIPS Role crustacean shells, and can be converted
Through the MIPS project, researchers are working to glucosamine, which is used in
to improve the overall process by removing the
requirement for bacterial growth using an enzyme- products sold as building blocks for
mediated process. The enzymes are already in use for cartilage.
the cell-based process. Operators responsible for the
NAG production will only need to add enzymes to the
raw material and employ a well-controlled bioprocess to
generate NAG. Designs for commercial-scale processing
will also be developed. A secondary objective of the
project is to evaluate processes for the conversion of the
resulting NAG to glucosamine (GlcN) and scout for the
most cost-effective recovery process for this product.
Results
While the project is in progress, several bacteria strains
have been identified.
85
86
Green Eyes
Development of ProbeGuard Anti-Biofouling Device
Business Description protective sensor “garage”. Both the outer (static) and
Green Eyes markets aquatic monitoring systems and inner (rotating) cups have windows that align to allow
services to academic, environmental consulting, sewage free communication with the ambient water in sampling
treatment and federal, state, and local government mode and are staggered in protected mode to block
water monitoring agencies. the sensors from the ambient water. Upon closing the
windows, a biocide is delivered by one to four compact
Challenge and highly efficient proprietary pumps. All activities of
Green Eyes sought to address a longstanding biofouling ProbeGuard are microprocessor-controlled, and the time
problem for aquatic instrumentation with the of all actions logged on non-volatile, on-board memory.
development and commercialization of ProbeGuard,
Results
The MIPS project enabled Green Eyes a product that controls biofouling on various moored
The successful project has enabled Green Eyes to market
aquatic instruments by enclosing sensors in a chamber
to create 16 jobs in Maryland. that is periodically treated with a biocide after data is Probeguard, which reduces servicing costs by 50-75
collected. The chamber is opened and flushed with percent while improving data quality. The system also
ambient water before sampling to insure data integrity. allows real-time access to data.
MIPS Role
Biofouling was identified by the Alliance for Coastal
Technologies (ACT) as a key problem for observing
systems that was yet to be solved. Through MIPS,
Green Eyes refined ProbeGuard, which addresses this
problem by using two concentric cups that form a
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88
GreenSpacers
Noah Berk,
Founder and CEO,
GreenSpacers
Growing fresh air with soil-free plants
Results
The products’ appeal is far reaching. GreenSpacers’
plants can be found in nearly 100 commercial locations.
Clients now include hospitals, medical offices,
commercial buildings, and local businesses that are
motivated to provide clean indoor air for employees,
customers and guests.
89
“Among the advances we have made
through MIPS is the construction of
a hydroponic conversion chamber, a
room with extra-high humidity and
heated floors, with lighting that’s been
placed in such a manner to grow low,
medium or high-light plants. It is the
only chamber of its kind in the U.S.”
– Noah Berk,
Founder and CEO, GreenSpacers
90
Hoopers Island Oyster Aquaculture
Salting system for oyster aquaculture
Business Description control the salinity of Chesapeake oysters for the half-
Hoopers Island’s mission is to lead the way in the shell market. This has long been done by watermen
development and implementation of a new and exciting by transporting mid-Bay oysters to the much saltier
oyster aquaculture industry in Dorchester County and waters of the barrier island bays below Ocean City and
the State of Maryland. Assateague Island. After living in these waters for a few
days, the oysters are significantly saltier and preferred by
Hoopers Island Oyster Aquaculture Company was the restaurant market. The MIPS project for a land-based
created to produce and market high-quality half-shell wet storage and salinity system will make this practice
oysters and the equipment needed to support the obsolete and provide far more control over the oyster
aquaculture industry in the State of Maryland. taste.
The company has successfully built equipment and
designed a system that will easily transition the MIPS Role
Hoopers Island is in the heart of Chesapeake seafood traditional methods of Maryland watermen into a While this project is in progress, UMD researchers are
country and is still home to the first Phillips Seafood cutting-edge industry. This industry will be one of the currently working with Hoopers to develop a wet storage
first steps forward in meeting society’s demands of system.
processing plant, which was the beginning of the
sustainability and transparency in seafood production.
famous Phillips Crab House and seafood empire in
Maryland. Steve Phillips, President and CEO of Phillips
Challenge
Seafood, has personally endorsed Hoopers Island Hoopers sought to develop a wet storage system for
Oyster Aquaculture Co. and has committed to being oysters to achieve salinity consistency and remove
one of the first customers for this new process. coliform bacteria. The challenge is to simulate and
91
“The opportunity provided by MIPS will fast-forward our
business by advancing our oyster aquaculture technology. The
after effects of this research made possible by MIPS will be an
asset for the Chesapeake Bay for years to come.”
– Ricky Fitzhugh, President, Hoopers
92
HY-TEK Bio
Clean energy from fossil fuels
Business Description
Pictured, from left to right: Feng Chen, Associate Professor, UMCES; Bob
Maryland-based HY-TEK Bio is an early stage company During phase two of the project, which ends in February,
Mroz, President and CEO, HY-TEK Bio; Jack French, Vice President, HY-TEK
developing a patent-pending system to remove carbon 2013, researches are fine-tuning the algae to perform at Bio.
dioxide and other harmful greenhouse gases from smoke an industrial scale in HY-TEK Bio’s system.
stack flue gas.
50 percent of the algae produced. The project ends in
MIPS Role November, 2012.
HY-TEK Bio’s system scrubs the gas by funneling it into a UMCES researchers isolated a new strain of algae from
sealed bioreactor that contains algae, wastewater, nutrient the Chesapeake Bay’s Back River tributary that grows MIPS-Related Quote
and LED lights. The algae feeds on pollutants in the fast, contains a 42-47 percent lipid content and survives “We’re moving to an entirely new concept in closed
wastewater and flue gas, yielding cleaner water and cleaner in environments with as much as 100 percent CO2. The bioreactor design using our patent-pending mylar
emissions. The process produces high-lipid-oil algae, a newly isolated strain was named HTB-1 for HY-TEK Bio 1. tank structure. This concept will revolutionize closed
key ingredient in bio-plastics and biofuels, some skin care bioreactors. Our new ½ scale (4’x20’) mylar bioreactor
products, nutritional supplements, cosmetic and paint During phase two, which is on-going, researchers are tank holds nine tons of water (or algae).
thickeners and additives for both human and animal food fine-tuning and optimizing components of the flue
products. gas-scrubbing system, including lighting, frequency, “HY-TEK Bio is a classic example of the Maryland
wavelength, duty cycling, bubble size absorption rates Industrial Partnerships Program making a difference in
Challenge and various sources of nutrients. helping a small company bring big ideas to market.
During phase one of HY-TEK Bio’s MIPS/DNR-funded — Bob Mroz, President and CEO, HY-TEK Bio
project, UMCES researchers planned to comb the Results
hundreds of thousands of strains of known algae to The City of Baltimore granted HY-TEK Bio $255,000 Interesting Facts
select the one that would perform best with HY-TEK to conduct a demonstration of their technology at HY-TEK Bio has received what it calls “off-the-scale”
Bio’s patented technology. The goal was to find one Baltimore City’s Back River Waste Water Treatment support from local companies in its preferred corporate
that could survive in an environment with 20 to 40 Plant. The project has already demonstrated that the sponsor program. More than 20 local companies have
percent CO2 and respond to certain light wavelengths technology works using just 10-foot tanks and providing provided HY-TEK Bio with hardware or services, at no
to promote faster growth. Ideally, the algae would also an 85-90 percent mitigation of harmful gases from the expense. Bob Mroz says “They just want to be involved,
have a high lipid content for later use in the products methane-fired power plant. Baltimore City receives even in this economy.”
mentioned above.
93
“As a result of the MIPS grant, we have
been able to garner the support of
Baltimore City for this project, which
was precisely the support we needed
to move towards commercialization.
MIPS has been the key to moving our
technology out of the lab and into the
marketplace.”
– Bob Mroz, President and CEO,
HY-TEK Bio
94
iBiquity Digital Corporation
HD Radio system testing at increased power levels
Project Manager: Albert Shuldiner; Principal Investigator: Ellyn Sheffield, Salisbury University
Location: Columbia, Maryland - Howard County; Project Start Date: 2/1/2007
Business Description MIPS Role seek FCC authorization for an overall increase in digital
iBiquity Digital is the developer and licenser of HD Salisbury researchers examined higher power levels power levels. Various broadcasters supported iBiquity’s
Radio™ Technology, which is transforming AM and for the digital carriers in the FM HD Radio system. The request to allow broadcasters to increase the power level
FM broadcasting with a vastly increased number of MIPS project focused on the feasibility of increasing of their digital radio broadcasts. On January 29, 2010,
channels, dramatically improved sound quality, and an power levels and the potential impact of that increase on the FCC issued an order authorizing FM radio stations
array of new data services. iBiquity is actively engaged adjacent analog channels. Increased digital power levels to increase their digital power levels based on the test
with broadcasters; receiver, component and broadcast allow broadcasters to increase the coverage of their results conducted pursuant to the MIPS grant. iBiquity
equipment manufacturers; automotive manufacturers; digital signals and to enhance the signal penetration also distributed results to regulators in other countries
and retailers in the United States and around the world of buildings. The project also involved the collection considering HD Radio adoption and to the International
to ensure swift and successful adoption of HD Radio of audio samples of analog radio programming from Telecommunication Union. The information about
Technology. several existing radio stations. Analog broadcasts were high-power FM broadcasts helped to encourage the
examined with the digital power of adjacent channel Mexican government to adopt HD Radio technology as
Challenge stations set to existing authorized levels and proposed the digital radio standard in Mexico earlier this year. The
iBiquity sought to obtain FCC clearance for the use of higher higher levels. A subjective evaluation of the audio FCC authorization of increased power resulted in several
broadcast power levels for the digital carriers in the FM HD samples was conducted using listeners to determine if dozen stations around the country increasing the power
Radio system. they perceive a diminution in audio quality. levels of their digital broadcasts and improving the
quality of their digital signals.
“This project has helped to strengthen the Results
value of our digital radio product, which in There was no appreciable decrease in audio quality
turn supports continued employment of 43 from the increase in digital power levels. This finding
allowed the broadcast industry to become comfortable
people in our Columbia, Maryland office.” with the benefits of increasing digital power levels
– Albert Shuldiner, Senior VP & General Counsel, for the HD Radio system and allowed the industry to
95
iBiquity Digital Corporation
96
Information Technologies Curves
Smart Algorithms for Managing Ridesharing Services
Project Manager: David Mohebbi; Principal Investigator: Dr. Elise Miller-Hooks, UMD
Location: Gaithersburg, Maryland - Montgomery County; Project Start Date: 8/1/2011
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98
Innovative Biosensors
Biosensor for Detecting Salmonella and Listeria
99
100
Instant Access Networks
EMP-protected microgrids using renewable energy
Project Manager: Charles L. Manto; Principal Investigator: Hilkat Soysal, Frostburg State
Location: Cumberland, Maryland - Allegany County; Project Start Date: 2 /1/2012, 10/1/2008
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InstantLabs Medical Diagnostics Corporation
Development of PCR assay for the detection of MRSA
Project Manager: Neil Sharma, Steven Guterman; Principal Investigator: Dr. Jennifer Kristie Johnson, UMB “The quality of the researchers and the
Location: Baltimore, Maryland - Baltimore City; Project Start Date: 8/1/2012
support from MIPS will allow us to enter
the market sooner.”
Business Description of hospital Staph isolates. MRSA is resistant to common – Steven Guterman, Chief Executive Officer, InstantLabs
InstantLabs is a molecular diagnostic device company antibiotics, and often results in serious illness and even
and the developer of portable, quantitative, real- death. It is an ever-increasing cause of community and
time PCR (qPCR) systems. The company is focused on hospital acquired infections worldwide.
medical diagnostic and food safety applications for its
proprietary technologies. InstantLabs currently markets The rapid diagnosis of MRSA is critical to both patient
its Hunter Accelerated-PCR® platform with disposable treatment and efficient hospital operations.
Multiple Assay Cartridges (MACs), bringing simplicity
and power to complex diagnostic testing without InstantLabs is seeking to develop a rapid method to
dependency on central laboratories or acute care detect Methicillin Resistant Staph Aureus (MRSA) on the
facilities for sample analysis. The compact, affordable Hunter® Real-Time Polymerase Chain Reaction (RT-PCR)
and fully-integrated Hunter system is especially suited platform. This will allow accurate and quick diagnosis of an
for use at points-of-care and points-of-need to detect increasingly important multi-drug resistant pathogen.
and analyze a wide variety of common and problematic
pathogens. InstantLabs is positioned to broaden the MIPS Role
addressable market for RT-PCR in areas where gold- Dr. Jennifer Kristie Johnson will design and test the PCR assays
standard accuracy combined with ease-of-use and rapid to detect MRSA.
time to results can make a consequential improvement
in operational efficiency as well as health outcomes. Interesting Fact
InstantLabs instrument, the Hunter, is not confined to human
Challenge diagnostics. it is used in food safety, and we are working on
Decision making for patients with a Staph infection used animal health test kits along with an industrial application.
to be easy. Simple, inexpensive antibiotics cured all but
the worst cases. However, in the early 1960’s, a new rare
pathogen appeared, Methicillin-Resistant Staphylococcus
Aureus (MRSA); it now represents more than 35 percent
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104
Integrated BioTherapeutics
Feasibility of Toxin Based S. Aureus Vaccine - PII
Business Description These infections are now more difficult to treat due to of sepsis in adults with a SA infection complicated by
IBT develops vaccines and therapeutics for S. aureus development of methicillin resistance. Consequently, bacteremia. Researchers also assessed whether adults
and filoviruses such as Ebola. The company’s vaccines the number of infections due to methicillin-resistant S. with persistent SA colonization have higher antibody
target a wide range of Staphylococcal exotoxins, major aureus (MRSA) has increased. SA most commonly causes levels.
virulence factors of S. aureus pathogenicity. skin and soft tissue infections with a range of severity,
from uncomplicated boils to life-threatening surgical Results
Challenge site infections. SA infections are often complicated In this trial, it was found that SA sepsis patients did
Staphylococcus aureus is a well-recognized cause of by bacteremia, the spread of the bacteria into the have significantly lower antibodies to SA toxins than
invasive disease and sepsis. Mortality rates related to bloodstream. SA bacteremia can lead to sepsis, a SA patients without sepsis. This finding may lead to
sepsis are high, despite appropriate antibiotic therapy. systemic response to the infections that leads to multi- a vaccine treatment for SA sepsis and has enabled
Why some patients with S. aureus bacteremia develop organ failure and often death. Efforts to develop a Integrated BioTherapuetics to create nine new jobs.
sepsis and others do not is largely unknown. Might vaccine to prevent SA infections have been unsuccessful.
low levels of antibodies to S. aureus exotoxins show However, no one has explored whether a vaccine
an association with sepsis risk among adults with against SA could reduce the severity of an SA infection.
bloodstream infection? And if so, might that lead to a SA produces a number of exotoxins that increase the
vaccine for treating that sepsis? severity of infection. The primary purpose of IBT’s MIPS
project was to determine the feasibility of developing a
MIPS Role toxin-based vaccine by assessing whether pre-existing
Staphylococcus aureus (SA) is a bacteria that causes antibodies to SA toxins are associated with a lower risk
both community- and hospital-acquired infections.
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106
Juxtopia
Auditorily-based speech enhancement scheme
107
Juxtopia is a minority-owned firm and a graduate of the ETC incubator. Juxtopia
returned to the ETC to create the Juxtopia® Urban Innovation and Cooperative
Entrepreneurship (JUICE) Lab with a mission to guide other minority-owned high-
tech companies to transition innovations and inventions into the commercial
marketplace.
108
K&L Microwave
Cross-coupled filter synthesis
109
“Dr. Zaki’s software is in use today in an expanded product line
and a new filter design, based on the use of high-temperature
superconducting materials.”
– Charles J. Schaub, President, K&L Microwave
110
Luke’s Premier Foods
Scale-up process for heirloom tomato juice
Business Description plants and moving with the seasons, similar to wheat Luke’s hired 11 people in 2012 and
The mission of Luke’s Premier Foods is to develop an harvesters and portable wine bottlers.
economical, environmentally friendly, mobile processing anticipates expanding that to 20 in
facility capable of using a waste crop (heirloom tomato MIPS Role 2013 by running two full shifts. Luke’s
seconds, even thirds) as the basis for the creation of MIPS made it possible to utilize the Food Science
a “micro-batch” canning plant, producing the best center at UMES and to test several different processes
entered the market in August, 2012
quality heirloom tomato juices in the world. This and pieces of equipment while utilizing feedback and and has sold more than 150 cases of
specific assistance from UMES professors.
includes development of the first commercially available premier heirloom tomato juices on the
heirloom tomato nectar. Luke’s plans to successfully
replicate the facility and products nationwide, then Results Eastern Shore in just the first month,
internationally. In 2012, Luke’s successfully proved the first tier of with tastings for grocers such as Whole
processing works by producing more than 4,000 cases
Challenge of premier heirloom tomato juice, tomato nectar, and Foods, Safeway and Dean & Deluca,
Luke’s first challenge was to prove their process is bloody mary mix and is marketing those juices now. upscale restaurants such as Liquid
sustainable when taken from “kitchen to commercial,”
while utilizing UMES food quality facilities and staff
Assets and Restaurant 213 in Salisbury,
knowledge to test equipment and procedures to fit popular clubs such as Seacrets in Ocean
within USDA guidelines. This has been successful. City, liquor stores such as Binn 66 in
The next step is to determine the maximum limits of
production, helping determine cost-effectiveness Rehoboth Beach, farm markets such as
and potential profitability while creating a new How Sweet It Is and Pops, and multiple
revenue stream for small- to medium-sized Maryland
tomato growers. The final challenge is creating mobile other locations, with sales to many . The
company is also developing potential
private label processing capabilities.
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“Because of the MIPS-funded
opportunity to incubate our project
at UMES, we have moved all of Luke’s
assets and business functions to
Princess Anne (from Iowa). Our project
would not have been possible without
MIPS and the extraordinary support
of Dr. Jurgen Schwarz at UMES. We
are proud to say Luke’s maintains our
99 percent “best tasting tomato juice I
have ever tasted” success.
– Jim Hudson, Owner, Luke’s
112
Mack Trucks
Improved reliability in truck powertrains
113
“Because of the MIPS funded
opportunity to incubate our project at
UMES, we have moved all Luke’s assets
and business functions to Princess
Anne, Maryland (from Iowa). Our
project would not have been possible
without MIPS, and the extraordinary
support of Dr. Jurgen Schwarz at UMES.
We are proud to say Luke’s maintains
our 99% “best tasting tomato juice I
have ever tasted” success.”
– Jim Hudson, Member/Owner
114
Maritime Applied Physics Corp.
High-performance, low fuel-use hydrofoil ferries
MIPS Role
Wind Tunnel researchers worked with MAPC to test and
improve the design of the company’s ferry hull.
115
“Because of the MIPS funded
opportunity to incubate our project at
UMES, we have moved all Luke’s assets
and business functions to Princess
Anne, Maryland (from Iowa). Our
project would not have been possible
without MIPS, and the extraordinary
support of Dr. Jurgen Schwarz at UMES.
We are proud to say Luke’s maintains
our 99% “best tasting tomato juice I
have ever tasted” success.”
– Jim Hudson, Member/Owner
116
Martek Biosciences
Microbial production of DHA
Project Manager: Richard Schuck; Principal Investigator: Andrew Lazur, UMCES, Horn Point
Location: Jarrettsville, Maryland - Harford County; Project Start Date: 8/2/2004
119
Maryland Aquatic Nurseries is the
largest supplier of aquatic plants
on the East Coast, and they
have one of the most beautiful
workplaces in Maryland!
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Maryland Environmental Plastics
Biodegradable plastic pots for vegetation restoration
Project Manager: Alan Berry and Chirp Shannahan; Principal Investigator: Patrick Kangas, UMD
Location: Easton, Maryland - Talbot County; Project Start Date: 2/1/2010
Because of the research conducted through the Business Description MIPS Role
Maryland Environmental Plasics (MEP) is an Easton, Md.- The MIPS/DNR-funded research project focused on the
MIPS program, the company has branched out
based startup dedicated to developing a biodegradable effects that a biodegradable seed pot would have in
and is working on other projects that will help seedling pot to enhance the growth and establishment establishing growth of SAV in the Chesapeake Bay Basin.
the crab industry in the Chesapeake Bay area, in of sub-aquatic vegetation (SAV) within the Chesapeake The objectives were to determine the best seedling pot
particular a new biodegradable “trap door” for Bay, restoring grasses that have been destroyed by design that would maximize vegetative growth, and
lost crab pots (ghost pots). pollutants. then allow that viable plant to be safely transplanted to a
site, with the intent of reestablishing the environmental
Challenge health of the Chesapeake Bay.
MEP sought to design a vessel that would allow seeds
to germinate and propagate without being removed by Results
tidal flow or consumed by creatures in the Bay. Secondly, The UMD research team designed a seedling pot, as well
the company needed to produce the vessel with a as a small ‘sod’ pot that can be used for growing SAV
material that would stand up to the rigors of the initial in a controlled environment for re-planting in strategic
germination, growth and placement in the Bay, but locations in the Bay. The company is currently working with
also naturally degrade in the sub-aquatic environment. environmental agencies in Maryland and Virginia to assess
Thirdly, the pot design had to be easily and economically the validity of the program. Implementation of the pot
produced via standard injection-molding production system is planned for early 2014.
processes.
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122
Matrics Technology Systems
Advanced RFID antenna designs
Project Manager: Dr. William R. Bandy; Principal Investigator: Kawthar A Zaki, UMD
Location: Columbia, Maryland - Howard County; Project Start Date: 2/1/2001
Challenge Results
Maxion sought to improve the performance of its The MIPS projects that Maxion undertook have helped
interband cascade (IC) laser. propel the company into a market leadership position
in mid-infrared lasers. The company has been working
extensively with U.S. federal agencies, including the
Department of Defense, the Department of Homeland
Security, and NASA.
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MedImmune
Characterization of Synagis®
Project Manager: Dr. John Hope; Principal Investigator: Dr. Bradford C. Braden, Bowie State
Location: Gaithersburg, Maryland - Montgomery County; Project Start Date: 2/1/2000
Business Description MIPS Role MIPS has jointly funded six different
Gaithersburg-based MedImmune is the global biologics Bowie State researchers characterized the three
arm of AstraZeneca PLC, with approximately 3,500 dimensional structure and physiochemical properties of research projects with MedImmune,
employees worldwide. Synagis®. including three directly related to
MedImmune’s Synagis® product is the first monoclonal Results
Synagis®, since 1996.
antibody approved for the prevention of an infectious Synagis® has therapeutic advantages over existing
disease, as well as the first such drug to be safely used in treatments, and has become a breakthrough product
children. with over $1B in sales per year and more than $11B
in sales historically. MedImmune was acquired by
Synagis® prevents a serious lower respiratory tract disease AstraZeneca in June, 2007, for $15.6B. They have 1,925
caused by the respiratory synctial virus (RSV), prominent employees in Maryland.
in the Northern Hemisphere during the winter months.
RSV is the most common respiratory infection for infants
and children. Approximately 50 percent of all infants are
MIPS “helped in [the] structural testing
infected with RSV during their first year of life; nearly all of Synagis lots,” said MedImmune
children have been infected at least once by the time they
scientist Dr. John Hope in a post-project
reach their second birthday.
report. “The process for which the MIPS
Challenge grant assisted in development of is still
MedImmune wanted to characterize the humanized
antibody Synagis® to identify potential changes in being used at MedImmune for testing
structure that occurred at the antigen binding site. This Synagis® and related glycoproteins.”
could possibly lead to a new antibody with improved
viral neutralizing characteristics.
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MedImmune
Bioprocess production training for Medimmune’s Synagis® production team
Business Description has been employed over the past 10 years by personnel “With the MIPS funding and
Gaithersburg-based MedImmune is the global biologics in Mtech’s Bioprocess Scale-Up Facility (BSF).
arm of AstraZeneca PLC, with approximately 3,500 MedImmune support that we received
employees worldwide. Interesting Fact we developed an interactive, on-line
The training module developed under MIPS has been
Challenge used to train almost all of MedImmune’s workers who
and self-paced training program that
MedImmune sought consistency in the manufacturing manufacture Synagis®, the company’s lead product. addressed each element of vaccine
Synagis® is the largest selling biotech product made
of Synagis®, the company’s lead product, manufactured
in Maryland, with cumulative sales of $11B. Synagis®
manufacturing, as conducted at
in Frederick. MedImmune’s manufacturing workers
needed training in their particular roles in the (palivizumab) is the first monoclonal antibody approved MedImmune. The project was a great
complicated manufacturing process. by the U.S. Food and Drug Administration (FDA) to help experience, and fostered a continuing
prevent an infectious disease.
MIPS Role relationship with MedImmune.”
The UMD team designed, developed and evaluated – Ed Sybert
enhanced bioprocessing training materials for
MedImmune’s production technicians.
Results
UMD researchers custom-designed a training program
for MedImmune’s manufacturing workers. This training
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130
Nora Therapeutics
Manufacturing and purification protocols for rhG-CSF
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132
Northrop Grumman Corporation
Weight measuring subsystem for a new, automated mail and document processing system
Project Manager: J.R. Seewagen, Robert Hosier; Principal Investigator: Uri Tasch, UMBC
Location: Linthicum, Maryland - Anne Arundel County; Project Start Date: 8/1/1992
Business Description
Northrop Grumman Corporation offers an extraordinary
portfolio of capabilities and technologies that enable the
company to deliver innovative systems and solutions for
applications that range from undersea to outer space and
into cyberspace.
Challenge
Northrop Grumman sought to develop a weight
measuring subsystem for the company’s new automated
mail and document processing system.
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134
Nutramax
Evaluation of Cosequin; pharmacokinetics of Cosequin and Cosamine
135
136
Omic Biosystems
DiART-enabled proteomic biomarker discovery
Omic Biosystems, Inc. was founded Business Description to study low abundance phosphorylated proteins within
Omic Biosystems Inc. has three business objectives: the “phosphoproteome,” and employ filamentous
around proprietary technology, DiART, omics reagent sales, biomarker service and biomarker fungi as a model cellular system to demonstrate the
developed in Dr. Shuwei Li’s laboratory discovery. The company is developing a novel DiART- effectiveness of DiART in biomarker discovery while
based protein phosphorylation assay platform that analyzing important fungal pathways involved in cell
at the University of Maryland at allows for the detection of low-abundance proteins in a wall synthesis.
College Park (UMD) and licensed to the more effective and economical way, making it useful for
Results
company. basic life science research, as well as for discovery efforts
The project is in progress and results are pending.
in the pharmaceutical and biotechnology industry.
Challenge
Omic wanted to identify disease-specific biomarkers
using modern systems biology tools and the former
University of Maryland Biotechnology Institute’s
proprietary Deuterium isobaric Amine Reactive
Tag (DiART) technology, which Omic Biosystems is
commercializing. Omic hopes to discover biomarkers
that have clinical significance and find new diagnostics
and drugs associated with these biomarkers.
MIPS Role
While this project is in progress, Omic plans to develop a
sensitive, rapid, and inexpensive DiART-based workflow
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138
OmniSpeech
Voice activity detection for speech extraction technology
Project Manager: Carol Espy-Wilson; Principal Investigator: Shihab Shamma M.D., UMD
Location: College Park, Maryland - Prince George’s; Project Start Date: 2/1/2011
Results
In 2012, OmniSpeech raised investment of up to $2
million from private investors. The company also won
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140
Optimal Solutions Group
Using artificial intelligence to reduce monitoring and knowledge diffusion costs for
Medicare Advantage Plans: a feasibility study
Project Manager: Mark Turner; Principal Investigator: Lise Getoor, UMD
Location: College Park, Maryland - Prince George’s; Project Start Date: 08/1/2011
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142
PharmAthene
Anthrax therapeutic
Project Manager: John Troyer; Principal Investigator: Alan Cross, Subhendu Basu, UMB
Location: Annapolis, Maryland - Anne Arundel County; Project Start Date: 8/2/2004
143
144
Pixelligent Technologies
Nanocrystal additives for increased resolution in photolithography
Business Description The big challenge in that area is to write more circuit has made in significantly scaling-up its manufacturing
Pixelligent Technologies is an innovator in manufacturing features on a chip of the same size. The limitation at that capacity. The company is now producing and shipping
high-quality nanocrystal additives and polymer time was based on the wavelength of light used to make its nanocrystal additives to customers around the world.
nanocomposites for the electronics, industrial, and military the chips. UMD researchers worked with Pixelligent
markets. on developing a new material, a reversible contrast Interesting Facts
enhancement layer (R-CEL), where a chemical layer is Pixelligent is a graduate of Mtech’s Technology
Pixelligent’s proprietary methodology for delivering used to focus the light and improve the resolution. Advancement Program (TAP) incubator. Pixelligent’s first
uniform dispersions is the best in the world. This is the three employees earned their Ph.D.s from the University
key enabling technology required to deliver the highest MIPS Role of Maryland. Founder Greg Cooper earned his Ph.D.
performance in a wide range of demanding and mission- UMD researchers started out working with organic dyes in Physics, Zhiyun Chen earned his Ph.D. in Electrical
critical applications. The company’s Zirconia and Hafnia for the chemical layer, then switched to nanoparticles. Enigineering, and Serpil Gonen Williams earned her
nanocrystals are used to improve the optical, electronic, UMD support helped Pixelligent as it transitioned this Ph.D. in Chemistry.
thermal, and mechanical properties of numerous polymer technology to other applications in semiconductor
systems. manufacturing and the electronics industry.
145
“Pixelligent is poised to take a leading role in this next
phase of the ‘nanotech revolution’ as we continue
to scale-up our manufacturing capacity to meet the
increased demand for our high-quality nanocrystal
additives.”
– Craig Bandes, President & CEO of Pixelligent Technologies
146
Plant Sensory Systems
Production of nematode-resistant soybeans
Project Manager: Frank Turano; Principal Investigator: Nadim Alkharouf, Towson University
Location: Baltimore, Maryland - Baltimore County; Project Start Date: 2/1/2011
147
“MIPS funding was the impetus in bringing together a team of
talented plant scientists from the university, federal government,
and small business sectors to work together on a project that
addresses a critical agronomic need. The positive results of the project
substantially broaden the commercial potential of the tested PSS
technology..”
148
– Frank Turano, Chief Research Officer and Co-Founder, Plant Sensory Systems
Profectus BioSciences
Cholera Toxin A1 subunit as an HIV DNA vaccine
149
150
Quantum Sail Design Group
High-performance offwind, racing sail testing and design
Project Manager: Per Andersson, Larry Leonard; Principal Investigator: Jewel Barlow, UMD
Location: Annapolis, Maryland - Anne Arundel County; Project Start Date: 2/1/1999
151
152
Recovery Science
Hand and finger training exoskeleton for rehabilitation and performance enhancement
Project Manager: Nayan R. Shah; Principal Investigator: Jae Kun Shim, UMD
Location: Hollywood, Maryland - St. Mary’s County; Project Start Date: 2/1/2009
MIPS Role
UMD researchers investigated the differences between
young and elderly persons in intrinsic and extrinsic
musculature and used the scientific evidence obtained
to develop a wearable, exoskeleton hand for differential
training of these target muscles. The device will be
used for hand and finger rehabilitation in the medical
community, as well as to enhance the performance of
athletes who use their hands during competitions.
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154
Remedium Technologies
Advanced bandage for severe bleeding
Challenge
Remedium was developing a tunable, tissue-adhesive
wound dressing (HemogripTM Pad) with applications in
trauma and cardiac catheterization procedures.
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156
Renewable Energy Solutions
Vertical axis wind turbine testing
Business Description RES, with its unique airfoil design, is trying to overcome Results
Renewable Energy Systems’ commercial and residential the deployment limitations of traditional horizontal The Wind Tunnel tests have generated a strong R&D
Marilyn turbine wind energy systems will bring axis wind turbines, enabling effective installation at interest from other academic institutions, including the
breakthrough, cost-effective wind power to suburban, just above rooftop heights and, more importantly, in University of Texas, whose researchers are building a
urban and rural users across the commercial, government locations not previously possible for HAWTs, such as prototype for a hybrid solar-wind turbine by deploying a
and residential markets. RES will be the worldwide industry atop tall buildings. photovoltaic thin film on top of Marilyn.
leader in small wind energy production systems in four
years. RES’ turbine system makes it possible to deploy small
wind systems in new urban and suburban markets
RES’ mission is to be the leading provider of small wind that traditionally were not considered for small wind
energy production systems for the commercial and implementations.
residential markets initially, and ultimately for a wider range
of energy applications by utilizing their breakthrough MIPS Role
Marilyn turbine design and cost-effective manufacturing A full-size Marilyn airfoil was tested in the Glenn. L.
process. Martin Wind Tunnel.
157
158
Resensys
Hybrid power cells for bridge health monitoring
MIPS Role
The goal of Resensys’ MIPS project was to adapt a
thin-film battery to work with the company’s sensors.
159
”MIPS is a great vehicle to leverage
research and expertise for small
companies like us in Maryland.”
– Mehdi Kalantari
President and Founder, Resensys
160
Rexahn Pharmaceuticals
Polymer-drug conjugates for cancer therapy
Business Description for Nanomedicine & Cellular Delivery (CNCD), in the “We are honored to have received [this]
Rexahn Pharmaceuticals Inc. is a publicly traded development of polymer-drug conjugates for the
clinical stage pharmaceutical company dedicated to targeted delivery of cancer drugs. The researchers grant from MIPS for our continued
commercializing first-in-class and best-in-class therapeutics attached anticancer drugs to a nontoxic, water-soluble cancer therapy research. Rexahn
for cancer and central nervous system (CNS) disorders. polymeric carrier so they could be localized
Rexahn currently has three drug candidates in Phase in the tumor area by a process known as enhanced
has the opportunity to potentially
II clinical trials, Archexin®, Serdaxin®, and Zoraxel™—all permeability and retention effect (EPR). Once the drug revolutionize the market for anti-cancer
attached to the polymer localized around tumors, the
potential best-in-class therapeutics. Rexahn also operates
cells engulfed the polymer-drug conjugate, cleaved the
treatment. The grant from MIPS gave
key R&D programs of nanomedicines, 3D-GOLD and TIMES
drug discovery platforms. bond between the drug and the polymer and released us the resources we needed to take our
the drug inside the tumor cells to kill cancer cells. work with the talented research team at
Challenge
A major problem with many cancer drugs is their lack Results UMB, to the next level.”
of tumor specificity and dose-limiting toxicity. The The project has shown that the polymer-drug conjugate – Dr. Chang Ahn,
ultimate purpose of Rexahn’s MIPS project was to reduce inhibited tumor growth significantly in tumor-bearing Chairman and Chief Executive Officer
Rexahn Pharmaceuticals Inc.
toxicity for patients and increase the efficacy of cancer animal models. Rexahn is conducting further preclinical
chemotherapeutics by selectively targeting them to development to move this project toward the human
tumor cells. trials.
MIPS Role
Rexahn worked with Dr. Anjan Nan, from UMB’s Center
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162
RioRey
Expand capabilities of a system to prevent Internet network attacks
MIPS Role
UMD researchers improved the processing speed and
expanded the algorithms of the system to handle
emerging attacks. They also studied the distribution of IP
addresses within an attack.
163
164
Sirnaomics
Silencing scar formation by targeting Hoxb13
MIPS Role
UMD researchers found a peptide (HK) that is an
effective carrier of RNAi to some tissues in animal
models. They proposed to show that an improved HK
carrier would greatly augment the delivery of siRNA-
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Dr. Patrick Y. Lu, the founder, President
and CEO of Sirnaomics, has 25 years
of biomedical research and 18 years of
biopharmaceutical industry experience
and is a veteran of several Maryland
biotech companies, including Intradigm
Corporation, Novartis and Digene.
166
Spessard Manufacturing
Electronic home plate
Project Manager: Leroy “Buzz” Chamberlain; Principal Investigator: Christopher Davis, UMD
Location: Hagerstown, Maryland - Washington County; Project Start Date: 2/1/2012
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168
Sterilex Corporation
Optimize disinfectant for dentists
Project Manager: Shira Kramer, PhD; Principal Investigator: Dr. Timothy Meiller, UMB
Location: Hunt Valley, Maryland - Baltimore County; Project Start Date: 8/1/1996
169
Sterilex is a woman-owned firm. Dr.
Kramer, the CEO, has served on the
MIPS advisory board and the Board
of Directors of the Organization for
Safety, Asepsis and Prevention.
170
Stress Indicators
SmartBolts production automation
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172
SullyPower (formerly ProParts LLC )
3D helix wind turbine
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174
Sustainable Systems
Aeolun Harvester(R) wind turbine evaluation
Project Manager: Terrence C. Sankar; Principal Investigator: Yizun Wang, Frostburg State
Location: Frostburg, Maryland - Allegany County; Project Start Date: 8/1/2009
Business Description A prototype vertical axis wind turbine unit was The Aeolun Harvester® is an instance of
Sustainable Systems Inc. (SSI) was created with the constructed and installled installed adjacent to the
Compton Science Center at Frostburg State University.
learning from and attempting to emulate
mission of creating a vertical axis wind turbine that was
efficient enough, cost-effective enough, and simple A smaller unit was tested in the Glenn L. Martin Wind nature, in this case hurricanes and tornadoes.
enough for ubiquitous deployment in rural, urban, Tunnel in College Park. The segments that make up the wind turbine
developed and under-developed settings, at scales of 2 are inherently simple entities and may be
to 100 kilowatt capacities. Results
The Aeolun Harvester® design, which has since won quite inexpensive to produce in a wide
Challenge a full design patent, has shown promising electricity variety of materials and sizes.
Sustainable Systems sought to test and evaluate its production efficiency and, in real-world conditions
Aeoulun Harvester®, a vertical axis wind turbine which (high wind events), has demonstrated its ability to stand
up to 80 mile-per-hour winds and continue operating
The origins of the geometry in the
uses an innovative active turbine design. The company
also planned to develop manufacturing and distribution throughout. In addition, the UMD Renewable Energy logarithmic spiral and Fibonacci series
processes to accomplish wide commercial deployment. Lab has chosen the Aeloun Harvester design and there embues the Aeouln Harvester® with a
will install a small system on their roof in the near future.
pleasing kinetic art appearance that lends
MIPS Role
Researchers provided test data, performance curves,
itself to deployment in the built environment.
materials guidelines, construction know-how and
installation methods for the commercial production and By operating through and surviving winds
sale of the Aeolun Harvester(R) vertical axis wind energy
in excess of 80 miles-per-hour, the Aeolun
conversion system.
Harvester® has demonstrated that it can
be safe in places where other wind turbine
designs might not be.
175
“MIPS has been, and continues to be, the great facilitator
of this undertaking, which we hope will be a significant
creator of well-paid and long-lasting Maryland jobs.”
– Dr. Terry Sankar, President and CEO, Sustainable Systems
176
Techno-Sciences Inc.
Semi-active magnetorheological seat suspension system
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Telcare
Cellular glucose meter for managing diabetes
Business Description providing personalized feedback will improve testing “MIPS has enabled us to do some
Telcare uses award-winning, cellular, machine-2-machine compliance, resulting in superior glycemic control as
technology to bridge the last mile between patients and measured by lowered glycosylated hemoglobin levels, of our most important research and
their caregivers in order to improve the care of chronic and improved patient satisfaction with care. development for this product. The
illness. Telcare’s first product is the Telcare BGM, a cellular-
enabled blood glucose meter for the 28 million Americans MIPS Role fact that MIPS invested us in this way
and 100 million addressable patients worldwide who UMB researchers have measured the results associated and recognized our technology was
with using Telcare’s two-way connection between
have diabetes that instantly transmits glucose values to a
patients and caregivers.
critical to attracting support from
care-management server and provides instant feedback
and coaching to patients with diabetes. In addition to Qualcomm, one of the nation’s largest
directly reducing cost of care by improving outcomes and Results companies and probably the world’s
preventing complications, Telcare creates an ecosystem of The Telcare Blood Glucose Monitoring System was
care that provides caregivers and disease managers with cleared by the FDA in 2011. The company raised 25.5 leading company in the area of wireless
previously-unavailable actionable clinical data. million in funding, led by new backer Sequoia Capital communications.”
with participation from its existing investor Qualcomm
Challenge Life Fund, in August, 2012. The Telcare BGM® device
— Jonathan C. Javitt, Vice Chairman,
Telcare sought a six-month clinical trial with patients won an E-tech Award at CTIA Wireless 2010, the People’s Telcare
with Type 1 and Type 2 diabetes to prove that Choice Award at CTIA Wireless 2009, and Best in Show at
connecting patients with diabetes to their care MobiTechFest 2009.
managers via a cellular-embedded glucose meter and
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180
Traffax
Traffax traffic detector design and testing; Bluetooth data dissemination
Project Manager: Dr. Stanley E. Young; Principal Investigator: Ali Haghani and Michael Pack, UMD
Location: College Park, Maryland - Prince George’s County; Project Start Date: 8/1/2008
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182
TRX Systems
Product life cycle assessment of TRX Sentinel
Challenge
to do.”
In June, 2012, TRX released NEON – a new personnel
In phase one of its MIPS project, TRX Systems sought – Carole Teolis, CTO and Chairman, TRX
location system that locates and tracks personnel
to ruggedize its indoor location system to withstand operating indoors and in urban areas where GPS is
the harsh environments in which first responders and MIPS Role unavailable or unreliable. The advantages of NEON
firefighters might need to operate. During phase two, In Phase one of the MIPS project, a high-reliability,
are improved situational awareness and command
high-temperature package was developed and the
effectiveness through the use of advanced sensor fusion,
MEMS sensors characterized to ensure the accurate
time of flight ranging, and mapping algorithms that
communication of location and vital signs information
deliver precise, real time location of personnel indoors.
of firefighters under extreme conditions. In Phase
two, researchers developed and conducted a series of
analyses and accelerated tests on the product to identify,
assess, and mitigate the dominant failure mechanisms to
which the product is susceptible in harsh environments.
Results
The two-phase MIPS project resulted in a design for
TRX’s tracking device enclosure. While the packaging has
evolved, the basic design and materials were developed
Project Manager: Craig E. Lindemann; Principal Investigator: Jae Kun Shim, UMD
Location: Baltimore, Maryland - Baltimore City; Project Start Date: 2/1/2012
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186
United Therapeutics
Development of a broad-spectrum, antiviral drug
Business Description test its efficacy against West Nile virus in mice, a key United Therapeutics has a market
United Therapeutics Corporation is a publicly traded proof-of-concept that will allow UT to select a final drug
biotechnology company focused on the development compound to move toward clinical trials. capitalization of $2.7B and 543
and commercialization of unique products to address employees. It is considered to be one of
the unmet medical needs of patients with chronic and Results
life-threatening conditions. On September 30, 2011, the Unither Virology LLC
Maryland’s top biotech companies.
subsidiary was awarded a contract with an aggregate
Challenge value of up to $45.0 million under a Broad Agency
UT sought to show that its unique glycobiology antiviral Announcement from the U.S. National Institute of
compounds could be effective against a wide variety Allergy and Infectious Diseases for studies directed at
of pathogens, including West Nile, Hepatitis C, and HIV the development of a broad spectrum antiviral drug
viruses. based on UT’s glycobiology antiviral platform. Products
are in pre-clinical development.
MIPS Role
Since 2008, UT has been actively collaborating with
UMD’s Maryland Pathogen Institute. Researchers
have been screening UT’s antiviral agents for activity
against West Nile virus in vitro. Dr. Brenda Fredericksen
worked with UT’s broad-spectrum antiviral drug to
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188
Universal Security Instruments
IoPhic advanced fire alarm technology
189
190
VisiSonics Corporation
Enhanced 3D audio experience via personalization
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192
WellDoc®
Mobile integrated therapies
Website: www.aemetis.com; Project Manager: Steven Hutcheson; Principal Investigators: Jonathan Dinman
and Robert Briber, UMD
Location: College Park, Maryland - Prince George’s County; Project Start Date: multiple dates