4.

Schematic Diagram Predisposing Factors Sex Female Reproductive Age Genetic Predisposition Nulliparous Early menarche Precipitating Factors Use of fertility pills Smoking Intake of fatty foods

Increased Estrogen and Progesterone levels in the Body

Abnormal growth factors are released In the system

Decreased cytokine production

Stimulation of uterine cell tissue

Increased uterine cell mitotic rate

Monoclonal proliferation of neoplastic uterine smooth muscle cells

Continuous growth of neoplasm with absence of tumor suppressor cells

Inhibition of apoptosis of neoplastic cells

Proliferated cells eventually form tissues

Development of uterine fibroid (leiyomyomas) withinin the myometrium

Intramural Myoma

Adequate vascular supply of O2 and nutrients Menorrhagia Constipation Urinary Frequency Difficult Defecation Abdominal Pain Abdominal Distension Abdominal Tenderness

Increase in size of uterine myoma

Palpable Abdominal Mass

Endometrial enlargement and distention

Impaired uterine lining

Blockage of fallopian tube

Distorted uterine shape

Impaired uterine function

Primary Infertility