Nephron Portion Reabsorbed Secreted Mechanisms of Major Characteristics

Reabsorption
Apical Basal/
Lateral
Proximal Tubule Na+, Cl-, HCO3-, K+, H+, Organic acids -Na/H -Na/K ATPase -65% H2O, Na+, K+, Urea reabsorbed
H2O, Glucose, aa’s and bases exchanger -HCO3- -100% glucose, aa, protein reabsorbed
-Bicarb buffer diffusion -H2O passively follows Na+ – Isosmotic
system reabsorption
Loop of Henle
• Thin Descending H2O Only None -Reabsorption 2° to cortical -Concentrates tubular fluid
medullary urea gradient
• Thin Ascending Na+ (passive) Urea -Impermeable to H2O
-Dilutes tubular fluid
• Thick Ascending Na+, Cl-, K+, Ca2+, H+ -Na/K/2Cl -Na/K ATPase -Impermeable to H2O
Mg2+, HCO3- cotransporter -K+ channel -Dilutes tubular fluid
-Na/H -Cl- channel -Na/K/2Cl cotransporter major
exchanger transporter ~20% NaCl reabsorbed –
-Lumen inhibited by furosemide
+potential
drives
paracellular
reabsorption
Na+,K+,Mg2+,Ca
2+

+ - 2+ 2+
Early Distal Tubule Na , Cl , Ca , Mg -NaCl -Na/K ATPase -Impermeable to H2O, Urea
transporter -Cl- channel -NaCl transporter inhibited by thiazides
Late Distal Tubule and Cortical
Collecting Duct
• Principal Cells Na+, Cl- K+ -ENaC channel -Na/K ATPase -EnaC blocked by Amiloride
-K+ channel -Cl- channel - Na/K ATPase regulated by Aldosterone
(secretion) – Aldosterone inhibited by
spironolactone
• Intercalated Cells H2O (+ADH only), H+ -Permeable to H2O only in presence of
HCO3-, K+ ADH
Medullary Collecting Duct Na+, Cl-, Urea, HCO3-, H+ -Permeable to H2O in presence of ADH
H2O (+ADH only) -Permeable to Urea
-Can actively secrete H+