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The effect of ascorbic acid deficiency on leukocyte phagocytosis and killing of actinomyces
Title:
viscosus.
Author: Goldschmidt, M C : Masin, W J : Brown, L R : Wyde, P R
Citation: Int-J-Vitam-Nutr-Res. 1988; 58(3): 326-34
The ascorbic acid content of guinea pig leukocytes is reduced by a factor of 16:1 between normal
and scorbutic guinea pigs. Ascorbic acid deficiencies do not appear to affect phagocytic activity
but do change leukocyte morphology. A deficiency of this vitamin appears to significantly
interfere with the in vitro bactericidal effectiveness of circulating leukocytes against ingested,
cell-associated, and extracellular bacterial cells of the oral pathogen, Actinomyces viscosus.
Leukocytes from scorbutic guinea pigs killed 13% of ingested and cell-associated Actinomyces
viscosus compared to 83% killed by normal leukocytes by both acridine orange staining and
Abstract:
viable count. Degranulation resulted in extracellular killing in normal but not scorbutic
leukocytes. This decreased bactericidal activity can be reversed by adding supplements of the
vitamin to the diet of scorbutic animals. Chemotactic responses were much lower in vivo and
absent in vitro in scorbutic leukocytes. The acridine orange staining technique is an excellent
indicator of leukocyte health. This study supports the important role for ascorbic acid in
leukocyte function and also discusses its probable protective and bactericidal activities related
to oral pathogens.
Review
None
References:
Copyright Hogrefe : & : Huber Publishers. Abstracts are reprinted by the permission of the
publisher of the journal for volume, pages, and dates cited. Hypertext links to electronic jo :
Notes:
urnal sites, if available, can be found in the the Peer Reviewed Journal List on the IBIDS home
page.
Language: English
Publication
Journal-Article
Type:
Actinomyces pathogenicity : Ascorbic Acid physiology : Ascorbic Acid Deficiency blood : Blood
Keywords:
Bactericidal Activity : Leukocytes physiology : Phagocytosis
URL: http://verlag.hanshuber.com/Zeitschriften/IJVNR/index.html

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