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Advanced Book Search <http://books.google.com.pk/advanced_book_search?q=pharmacodynamics+mcqs> Books </books> <http://books.google.com.pk/books?op=lookup&id=YEENOJtK8NMC&continue=http://book s.google.com.pk/books%3Fid%3DYEENOJtK8NMC%26pg%3DPA1%26lpg%3DPA1%26dq%3Dpharmaco dynamics%2Bmcqs%26source%3Dbl%26ots%3DTrtOSP1cbT%26sig%3Djc0Gq8Uw7bFvS3X2YO3NR6m vr0U%26hl%3Den%26sa%3DX%26ei%3DyqRqUY_-J4-zhAft_4DoDg><http://books.google.com.p k/books?id=YEENOJtK8NMC&printsec=frontcover&source=gbs_vpt_read> Add to my library Write review Page 1 books.google.com.pkhttp://books.google.com.pk/books/about/MCQs_in_PHARMACOLOGY_W ith_Explanitory_An.html?id=YEENOJtK8NMC&utm_source=gb-gplus-shareMCQs in PHARMACOLOGY With Explanitory AnswersMCQs in PHARMACOLOGY With Explanitory Answers Page vi This book does not attempt to compete with the existing books on the subject, whether textbooks or *MCQ* books, but, because of its slightly different emphasis, we hope it will *...* Pharmacokinetics and *Pharmacodynamics* (PK-PD) 1 2. Page vii Pharmacokinetics and *Pharmacodynamics* (PK-PD) 1 2. Autonomic Nervous System (ANS) 25 3. Central Nervous System (CNS) 47 4. Cardiovascular System (CVS) 80 6. Endocrinology 111 7. Autacoids and Opioids 8. Gastroenterology 9. Page 1 *Pharmacodynamics*. (PK-PD). 1. Rectal route of administration is characterized by all of the following, except: 1. Irritant drugs should preferably be given via this route rather than intravenously 2. As the absorption is irregular, the blood levels *...* Page 3 When *pharmacodynamic* tolerance to a drug is known to occur 5. For sustained release (SR) preparations 12. Which of the following antibiotics should not be administered to a patient whose renal function is severely compromised? 1. Page 5 *...* that digoxin levels should be maintained <1 ng/mL, digoxin was stopped. The following aspects of his management can be considered: 1. If the digoxin blood level on the next day Pharmacokinetics and *Pharmacodynamics* (PK-PD) 5. Page 7 *...* enzymes have been cloned 5. Interindividual variability in expression is seen with both CYPs as well as enzymes 34. Xenobiotic metabolism is traditionally considered to be carried out Pharmacokinetics and *Pharmacodynamics* (PK-PD) 7. Page 9 *...* drugs is significantly increased in patients with impaired hepatic function? 1.

Morphine 2. Midazolam 3. Digoxin 4. Amikacin 5. Nifedipine 45. In general, potency of a drug is not considered Pharmacokinetics and *Pharmacodynamics* ( PK-PD) 9. Page 10 The variability in *pharmacodynamic* effects of drugs is characterized by all of the following, except: 1. Drug response may *...* useful 49. Which of the following are examples of targeted drug 1 0 *MCQs* in Pharmacology with Explanatory Answers. Page 11 *...* of receptor can never antagonize a partial agonist 5. Famotidine and losartan can be considered partial agonists ANSWERS WITH EXPLANATION Ans. 1: 1, 3 Explanation: Many drugs Pharmacokinetics and *Pharmacodynamics* (PK-PD) 11. Page 13 *...* of alcohol, phenytoin, salicylates and other drugs to be nonlinear or zero order. However, all the processes in the body can be saturable and thus nonlinear. For example, GI absorption Pharmacokinetics and *Pharmacodynamics* (PK-PD) 13. Page 14 If *pharmacodynamic* tolerance to a drug is known to occur (morphine), the correlation between effect and concentration may not be *...* Depletion of norepinephrine by reserpine and depletion 14 *MCQs* in Pharmacology with Explanatory Answers. Page 15 Although *pharmacodynamic* tolerance is better characterized, pharmacokinetic tolerance may also occur. *Pharmacodynamic* tolerance can occur because of reduction in the number of receptors, decreased synthesis or depletion of mediators, *...* Page 17 *...* to improvement in bioavailability. Usually drugs with half-lives greater than 8 hours are not considered suitable for making a CR preparation as they may not provide much additional benefit over Pharmacokinetics and *Pharmacodynamics* *...* Page 19 *...* ensure the metabolism of most of the xenobiotics. CYP3A4 is the most abundant CYP that metabolizes about 50 percent of all drugs. Ans. 33: 2, 4, 5 Explanation: CYPs are known by Pharmacokinetics and *Pharmacodynamics* (PKPD) 19. Page 21 *...* is a member of transcription factor superfamily and has a definite role in CNS development and body response to stress. When a ligand such as omeprazole binds to AHR, it leads to induction of Pharmacokinetics and *Pharmacodynamics* *...* Page 22 Ans. 46: 4, 5 Explanation: *Pharmacodynamic* variability implies different response at same concentrations in the same *...* the slope of this concentrationpercent curve gives an idea about the *pharmacodynamic* variability in the 22 *MCQs* in *...* Page 23 percent curve gives an idea about the *pharmacodynamic* variability in the

population. It arises because of differences in age, sex, genetics, concomitant diseases and drugs and no single factor may alone be responsible. Ans. 47: 1, 2, *...* Page 62 ANSWERS WITH EXPLANATION Ans. 1: 2, 3 Explanation: Differences in *pharmacodynamics* between adults and children do exist. Amongst the most *...* Ans. 6: 3, 5 Explanation: Acute low back pain refers 62 *MCQs* in Pharmacology with *...* Page 77 In contrast, acquired tolerance is one that develops with the use of a drug it can be pharmacokinetic, *pharmacodynamic* or learned. Pharmacokinetic tolerance is known to develop if repeated administration produces lower concentration *...* Page 95 These include macrolides, HMG-CoA reductase inhibitors, imidazoles, cyclosporine, omeprazole, protease inhibitors, quinidine, verapamil, etc. Nitrates cause a *pharmacodynamic* interaction with sildenafil, leading to hypotension; a marked *...* Page 137 *...* 5 Explanation: The interaction between ACE inhibitors and NSAIDs is *pharmacodynamic* and not pharmacokinetic. It is believed that part of the antihypertensive effect of ACE inhibitors is through prostaglandins (vasodilatory and natriuretic) *...* Page 192 Which of the following alterations in *pharmacodynamic* actions of morphine can be present in the elderly? 1. Increase in abuse potential 2. Increase in analgesic effect 3. Increase in respiratory depression 4. Increase in nausea, vomiting 5. Page 198 Helps to distinguish between pharmacokinetics and *pharmacodynamics* of a drug 3. Allows us to distinguish between *...* variability is high 35. It is not advisable to use crossover design in 1 98 *MCQs* in Pharmacology with Explanatory Answers. Page 201 However, in general, the lesser the frequency, the better is the compliance, irrespective of the cost. Ans. 2: 1, 2 Explanation: Due to age-related *pharmacodynamic* changes (exact cause unknown) occurring in the elderly, the antihypertensive *...* Page 204 *...* drug treatment because there is a lot of interindividual variability in the pharmacokinetics as well as *pharmacodynamics*. *...* Ans. 18: 2, 3, 4 Explanation: Levodopa absorption may be 204 *MCQs* in Pharmacology with Explanatory Answers. Page 205 Therefore, it is difficult to make any generalizations. Moreover, it must also be

established that there are no pharmacokinetic changes in the elderly; only then we can think of *pharmacodynamic* changes. The heart rate response to adenosine is *...* Get print book <http://books.google.com.pk/books?id=YEENOJtK8NMC&sitesec=buy&source=gbs_vpt_rea d> No eBook available Amazon.com <http://www.amazon.com/gp/search?index=books&linkCode=qs&keywords=8184483872> Find in a library <http://books.google.com.pk/url?id=YEENOJtK8NMC&pg=PA1&q=http://worldcat.org/isb n/8184483872&clientid=librarylink&usg=AFQjCNFlZaL73D7cY1UNKGpIF_rgBxJTBg&source= gbs_buy_r> All sellers <http://books.google.com.pk/books?id=YEENOJtK8NMC&sitesec=buy&source=gbs_buy_r> Front Cover <http://books.google.com.pk/books?id=YEENOJtK8NMC&printsec=frontcover> <http://books.google.com.pk/books?id=YEENOJtK8NMC&dq=pharmacodynamics+mcqs&sites ec=reviews> 1 Review <http://books.google.com.pk/books?id=YEENOJtK8NMC&dq=pharmacodynamics+mcqs&sites ec=reviews>Write review <http://books.google.com.pk/books?op=lookup&id=YEENOJtK8NMC&continue=http://book s.google.com.pk/books%3Fid%3DYEENOJtK8NMC%26pg%3DPA1%26lpg%3DPA1%26dq%3Dpharmaco dynamics%2Bmcqs%26source%3Dbl%26ots%3DTrtOSP1cbT%26sig%3Djc0Gq8Uw7bFvS3X2YO3NR6m vr0U%26hl%3Den%26sa%3DX%26ei%3DyqRqUY_-J4-zhAft_4DoDg>http://books.google.com.pk /books/about/MCQs_in_PHARMACOLOGY_With_Explanitory_An.html?id=YEENOJtK8NMC MCQs in PHARMACOLOGY With Explanitory Answers

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