Professional Documents
Culture Documents
PRTICA DE
FARMACOTCNICA
I
Prof. Herbert Cristian de Souza
2012-02
SUMRIO
AULA 1. SAIS PARA BANHO EFERVESCENTE
AULA 2. P SECATIVO
AULA 4. P ANTI-CIDO
10
11
12
13
14
15
17
18
19
20
22
23
AVISOS IMPORTANTES
A chamada ser feita com 15 minutos de aula. Portanto a tolerncia mxima para chegar ao
laboratrio at as 21:05 min;
Os alunos s podero fazer aula prtica se estiverem devidamente vestidos;
As fichas tcnicas devero ser confeccionadas antes da execuo das frmulas;
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4
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
5
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 1.
COMPONENTES DA FORMULAO
Cloreto de sdio
Cloreto de magnsio
cido ctrico
Bicarbonato de sdio
Fragrncia
Corante em soluo
PESO
PRTICO
FUNO
FARMACUTICA
40%
10%
20%
30%
q.s
q.s
MATERIAL UTILIZADO:
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TCNICA DE PREPARO
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
6
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 2.
COMPONENTES DA FORMULAO
xido de zinco
Mentol
Cnfora
Amido
Talco
q.s.p
P SECATIVO
PESO
TERICO
1,5g
0,25g
0,25g
1,50g
25,0g
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
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25. _______________________________________________________________________________
DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
7
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 3.
COMPONENTES DA FORMULAO
cido brico
cido benzico
cido saliclico
Mentol
Cnfora
Amido
xido de zinco
Talco
q.s.p
P DESODORANTE PARA OS PS
PESO
TERICO
4,50g
2,25g
0,90g
0,30g
0,30g
2,25g
2,25g
45,0g
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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__________________________________________________________________________________________
TCNICA DE PREPARO
1. _______________________________________________________________________________
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3. _______________________________________________________________________________
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
8
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 4.
COMPONENTES DA FORMULAO
Carbonato de clcio
Carbonato de magnsio
Carbonato de sdio
Caulim (silicato de alumnio) ou amido
P ANTI-CIDO
PESO
TERICO
32,0g
32,0g
26,0g
10,0g
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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TCNICA DE PREPARO
1. _______________________________________________________________________________
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
9
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 5.
COMPONENTES DA FORMULAO
Sulfato de magnsio
cido tartrico
Bicarbonato de sdio
Sacarose
PESO
TERICO
8,7 g
11,4 g
12,8 g
18,6 g
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
10
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 6.
COMPONENTES DA FORMULAO
Dextrose anidra
Cloreto de sdio
Citrato de potssio
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
__________________________________________________________________________________________
__________________________________________________________________________________________
TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
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25. _______________________________________________________________________________
DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
11
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 7.
COMPONENTES DA FORMULAO
Fosfato de sdio
Bicarbonato de sdio
PESO
TERICO
0,2g
4,8g
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
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25. _______________________________________________________________________________
DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
12
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 8.
COMPONENTES DA FORMULAO
Cloreto de potssio
Citrato de sdio
Cloreto de sdio
Glicose
PESO
TERICO
0,75g
1,45g
1,75g
10,0g
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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TCNICA DE PREPARO
1. _______________________________________________________________________________
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
13
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 9.
COMPONENTES DA FORMULAO
Brometo de escopolamina (1:10)
Lactose
PESO
TERICO
5mg
2,495mg
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
__________________________________________________________________________________________
__________________________________________________________________________________________
TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
14
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 10.
COMPONENTES DA FORMULAO
Glicerofosfato de clcio
Acar
Corante
Xarope de groselha
GRANULADO RECALCIFICANTE
PESO
TERICO
2,0g
20,0g
q.s
q.s
aglutinar
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
15
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 11.
COMPONENTES DA FORMULAO
Salicilato de sdio
cido ctrico
Bicarbonato de sdio
Lactato de sdio
Sulfato de magnsio
PESO
TERICO
15g
34g
30g
10g
10g
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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__________________________________________________________________________________________
TCNICA DE PREPARO
1. _______________________________________________________________________________
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DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
16
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
CPSULAS
So formas farmacuticas slidas que envolvem o frmaco em invlucros duros
constitudos de gelatina. Os invlucros possuem diferentes tamanhos, os quais so
escolhidos de acordo com a quantidade de matria-prima a ser encapsulada, de
acordo com a tabela abaixo:
n da cpsula
5
4
3
2
1
0
00
000
Capacidade mdia de ps em mg
At 65mg
65mg a 100mg
130mg a 200mg
200mg a 350mg
350mg a 550mg
550mg a 750mg
750mg a 975mg
975mg a 1400mg
17
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 12.
COMPONENTES DA FORMULAO
Paracetamol
Cimetidina
Carbonato de clcio
CPSULA ANTI-CIDA
PESO
TERICO
300mg
100mg
10mg
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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__________________________________________________________________________________________
TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
4. _______________________________________________________________________________
5. _______________________________________________________________________________
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25. _______________________________________________________________________________
DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
18
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 13.
COMPONENTES DA FORMULAO
Sene em p
Cascara sagrada
CPSULA LAXANTE
PESO
TERICO
50mg
300mg
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
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__________________________________________________________________________________________
TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
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25. _______________________________________________________________________________
DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
19
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 14.
COMPONENTES DA FORMULAO
Diclofenaco sdico
Paracetamol
CPSULA ANTI-INFLAMATRIA
PESO
TERICO
50mg
300mg
PESO
PRTICO
FUNO
FARMACUTICA
MATERIAL UTILIZADO:
__________________________________________________________________________________________
__________________________________________________________________________________________
TCNICA DE PREPARO
1. _______________________________________________________________________________
2. _______________________________________________________________________________
3. _______________________________________________________________________________
4. _______________________________________________________________________________
5. _______________________________________________________________________________
6. _______________________________________________________________________________
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24. _______________________________________________________________________________
25. _______________________________________________________________________________
DATA DE FABRICAO ______/______/_______
DATA DE VALIDADE _____/______/______
ASS. ALUNO ___________________________ VISTO DO PROFESSOR_____________________________
USO FARMACUTICO____________________________________________________________________
20
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 15.
DILUIO GEOMTRICA
Pesar: 1g PA e 9g Diluente
Transferir o diluente para o gral de porcelana
Triturar o diluente, para fechar os poros.
Retirar o diluente
Transferir para o gral: 1g PA, 1g Diluente e corante (opcional)
Triturar at perfeita homogeneizao
Acrescentar 2 g do diluente e homogeneizar
Acrescentar 4 g do diluente e homogeneizar
Acrescentar 2 g do diluente e homogeneizar
DICAS PARA A
HIGROSCPICOS
MANIPULAO
DE
CPSULAS
CONTENDO
FRMACOS
21
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
Obs.: Aerosil 200 tambm possui alguns sinnimos comerciais como Dixido de
Silcio Coloidal, Slica Coloidal Anidra, Aerosil ou Cab-O-Sil
Obs. 2: Para medir a higroscopicidade de uma matria prima faa um teste simples:
Tare um papel-filtro (daqueles redondos utilizados em laboratrios de qumica
analtica para filtragem simples) e pese 1g da matria prima a ser analisada. Deixe por
10 minutos e retire, quanto mais ativo impregnar no papel filtro mais higroscpica a
matria prima. Por exemplo se 0,7g continuar no papel a matria prima 70%
higroscpica (alta higroscopicidade). Lembre-se que estes testes dependem das
condies de temperatura e umidade do seu Laboratrio de Controle de Qualidade.
22
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 16.
Nome:
Amoxicilina triidratada
Sinonmia:
No referenciado
Frmula molecular:
C16H19N3O5S.3H2O
Forma qumica:
Base
Fator de equivalncia:
1,15
LAUDO DE MATRIA-PRIMA
N DCB
00736
Cd. DCB
00543.03-9
N CAS
61336-70-7
Peso molecular:
419,46
Fator de correo:
Consultar o certificado de anlise da matria-prima para
verificar a necessidade de aplicar o fator de correo
Cpsulas, comprimidos, ps
para suspenses orais,
suspenses orais, infuses
intramamrias e suspenses
injetveis
Usos:
Antibitico; Antibacteriano
Grau de pureza / aplicao:
Grau farmacutico
Especificao Geral
Teor ou Potncia: Mnimo de 900g e mximo de 1050g
Identificao
Espectrofotometria de absoro no infravermelho, espectro da amostra apresenta mximos de absoro somente nos
mesmos comprimentos de onda e com as mesmas intensidades relativas daqueles observados no espectro da substncia
padro
Espectrofotometria de absoro no ultravioleta, a soluo da amostra apresenta mximos de absoro em 230nm e em
274nm, idntico aos observados no espectro da substncia padro
Cromatografia em camada delgada, com obteno de mancha principal de posio, cor e intensidade similar a obtida
com a substncia padro
Ensaios de Pureza
pH: 3,5 a 6,0 (Soluo a 0,2% (p/V))
Cinzas sulfatadas: No mximo 1,0%
gua: Entre 11,5 e 14,5%
Embalagem e Armazenamento
Armazenar em recipientes bem fechados, protegidos do ar e da luz, a temperatura inferior a 30C
Amostragem
Verificar procedimento geral e/ou especfico de amostragem.
Precaues
Observar descrito na FISPQ.
Referncias
a
Elaborado por:
FARMCIA UNIPAC - ARAGUARI
Aprovado por:
Data:
Reviso n:
N de pgina:
de 1 at 1
23
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
AULA 17.
1)
CLCULOS DE PESAGEM
a)
Qual a quantidade em gramas de cada substncia nas seguintes formulaes? Demonstre os
clculos.
Frmula 1
Uria ............................................3,0%
cido saliclico..............................1,0%
cido ltico....................................2,0%
Peso total da frmula...................200g
Frmula 2
xido de zinco...............................1,5%
Mentol...........................................0,5%
Cnfora..........................................1,0%
Amido...........................................20,0%
Peso total da frmula.....................150g
b)
Quanto de cada componente abaixo dever ser pesado para se preparar 180 cpsulas?
Piridoxina.......................................60mg
Cistina...........................................200mg
Famotidina.....................................25mg
Alcachofra extrato seco..................50mg
c)
Na seguinte formulao, determine a quantidade de cada componente para a obteno de
500g do produto final.
cido brico......................................5,0g
Amido...............................................20,0g
Talco.................................................50,0g
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APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
2)
Representa a soma de todas as substncias, subtraindo a quantidade total solicitada. O q.s.p indica,
em geral, o peso total da formulao, sendo representado quase sempre pelos excipientes.
a)
Frmula 1
Cscara sagrada..............................100mg
Espirulina.........................................200mg
Excipiente...............q.s.p.................500mg
Frmula 2
cido brico.....................................6,0g
cido saliclico.................................1,5g
Amido..............................................5,0g
Viofrmio........................................1,0g
Talco...................q.s.p....................90,0g
3)
CLCULOS DE DILUIES
Vitamina B12..................1:100 indica que o frmaco diludo 100x, ou seja, 1mg de Vitamina B12
equivale a 100mg do diludo.
a)
Calcule o peso de cada frmaco para se fazer 100 cpsulas. Cada 50.000UI de vitamina A
equivale a 1g de vitamina A acetato.
Piridoxina (1:2) ....................................30mg
Cistina (1:10).........................................20mg
Vitamina B12 (1:100)...........................100mcg
Biotina (1:10)........................................0,2mg
Vitamina A .........................................25.000UI
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APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
4)
O Fator de Correo (Fc) utilizado para corrigir a diluio de uma substncia, ou o teor do princpio
ativo, ou o teor elementar de um mineral ou ainda a umidade. Esses acertos so feitos com base nos
certificados das matrias-primas ou nas diluies feitas na prpria farmcia.
Muitas matrias-primas so comercializadas na forma diluda pelo fabricante, e com isso o clculo do
Fc deve ser feito para 100%. Para o clculo do Fc devem ser considerados:
A. FATOR DE CORREO PELA POTNCIA DO FRMACO
Fc = 100%
Teor%
Peso Total = Peso P.A x Fc
Exerccios
1)
Calcule o Fc dos seguintes frmacos, e indique qual a quantidade que dever ser pesada para
se preparar 120 cps.
Clcio quelato (18% - significa que o teor do Clcio de 18%)...........................0,10mg
Carbonato de clcio (40%)..................0,20mg
Carbonato de magnsio (40%)............0,33mg
Cobre sulfato (25%)............................0,20mg
Excipiente q.s.p.....................................1cps
2)
3)
Betacaroteno..................10mg/cpsula.
Matria-prima disponvel: betacaroteno 11%
B. TEOR DE UMIDADE
Fc = 100%
100% - Teor de umidade%
26
APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
1)
Faa a correo do cido Flico que contm 5mg/cpsula, sendo que a matria-prima
disponvel tem 12% de umidade.
2)
3)
O laudo de Aciclovir relata que este frmaco est com 5% de umidade. Sabendo que o PM do
aciclovir de 225,2g, encontre a massa que corresponde aos 5% de umidade.
1) Calcule quanto de cada frmaco dever ser pesado para atenda a diluio do mesmo.
FRMACO
[ ]
Diazepan 1/10
1mg (P.A)..........................10mg (Diludo)
20mg (P.A).........................X (Diludo)
20 mg
X=200mg de diludo. Ou seja, dever ser pesado 200mg de diludo para que contenha
apenas 20mg de frmaco.
Finasterida 1/10
5 mg
cido Flico 1/10
20 mg
Clonidina 1/100
0,1 mg
Digoxina 1/100
0,25
mg
Triac 1/100
700 g
T3 1/1000
10 g
T4 1/1000
200 g
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APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
5)
FATOR DE EQUIVALNCIA
1)
Calcule o Feq do estolato de eritromicina.
Dados: PM Estolato de eritromicina 1056,41. PM de Eritromicina base 733,94
2)
a.
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APOSTILA PRTICA DE FARMACOTCNICA I UNIPAC ARAGUARI
PROF. HERBERT CRISTIAN DE SOUZA
3)
Calcule o Feq da amoxicilina Trihidratada.
a.
Dados: PM da molcula de amoxicilina trihidratada 419,46. PM da molcula de amoxicilina
anidra 365,41
4)
Calcule a quantidade de cada componente para fazer 60 cpsulas da seguinte frmula:
Cloridrato de Sertralina...................................50mg
Cloridrato de fluoxetina..................................12mg
Dados: PM do HCl Sertralina 342,69 / PM da Sertralina Base 305,97
PM do HCl Fluoxetina 345,79 / PM da Fluoxetina Base 308,74