Allergen and prevention

(allergen)
(allergen) (IgE-mediated
reaction)
(glycoprotein) 10,000 40,000
(aeroallergen) allergen

aeroallergen 2 60 micron
aeroallergen modify allergic reaction
hydrocarbon chlorine, hydrogen sulfide, formaldehyde

1. Gravitational methods (Durham sampler)

slide glycerin jelly 2
24 turbulent airflow
identify


2. Volumetric methods
- rotating air impactor slide slide

slide Rotorod sampler,
intermittent rotoslide sampler
- inertial suction samplers
plate
Burkhard spore trap, Accuvol

179

 (aeroallergen)
aeroallergen 2
1. indoor allergen allergen allergen house dust
mite, cat, dog, cockroach, indoor mold
2. outdoor allergen allergen allergen
allergen outdoor mold
(pollen antigen)
allergen


5 - 60
pollen aeroallergen

(Bermuda) (Para grass) (Johnson grass) (sedge)

(Careless weed) (English plantain)
(Acacia) (Casuarina) (Mimosa)

1. picnic, camping, jogging

2.

3. (HEPA)
(mold antigen)

180


10
aeroallergen Cladosporium, Fusarium, Aspergillus, Alternaria,
Penicillium, Monilia, Yeast, Helminthosporium, Curvularia

1. Lysol, Clorox

2.

3.

4.
5.
6.
7. 1-2 3-4
8.
9.
10.
11.
12. (dehumidifier)
13.
14.
(cockroach antigen)

49% 37%

181


1.
-

-
-
-
-
-
-
2.
Lysol Lysol

3.
- boric acid

-
-
4.
-

(cat antigen)

purify Fel d I
cat albumin Fel
dI
Fel d I > 8 g/g of dust
Fel D I < 0.2 g/g 80 g/g
cat antigen

182

 Fel d I 2.5 10
Fel d I

20 24
Fel d I 8 g/g of dust sensitized level

1.
2.
cat allergen
3.
4.
5.

6. HEPA filter 3% Tannic acid cat

allergen 4
cat allergen
7. (HEPA filter)
8.
(dog antigen)
Can f I dog
albumin Can f I
Ig E sensitization 10 g/g of dust
10

1.
2.

3.
183

4.
5. , ,

6. HEPA filter
7. (HEPA filter)
8.
(dust mite)
.. 1967
62
84
class Arachnida, subclass Acari, order Astigmata, family Pyroglyphidae
Dermatophagoides, Euroglyphus, family storage mite
Lepidoglyphus, Blomia, Tyrophagus
Dermatophagoides pteronyssinus, Dermatophagoides
farinae
8 0.3 mm. (hygroscopic)

75 80
(poikilothermic)
25 30C


1 1,000,000 1

(
200,000 )
2 20 - 50
3
18
enzyme
protease, glutathione, transferase heat shock protein, high density lipoprotein
group
184

15. group I allergens purify .. 1980 glycoprotein proteolytic enzyme

25 kDa
Der p I, Der f I allergen 550 C
16. group II allergens 14 kDa Der p II, Der f II
100 / 1 group I antigen 2
/ 1 specific IgE mite antigen
sensitization level
500 1 group I antigen
10 / 1

1.
polyurethane

(

2. 55 - 60 30
100




2
3. dacron


4.

5.

185

6.
7.
8. Benzyl benzoate, Pyrethroids, Pirimiphos methyl
3% Tannic acid
4

9. 3 4
10.

11. HEPA (high efficiency particulate air filter)

12.

1.

2.

3. ozone ozone
ozone

186


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10. . . 2541; 115-130.

187