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  • Characteristics: Year Location N.O. of Persons Affected Putative Mode of Transmittion

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    Gregório Gomes
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    There are 4 known genotypes of hepatitis E virus (HEV). HEV1 and HEV2 primarily cause large waterborne outbreaks in developing countries, while HEV3 and HEV4 typically cause sporadic cases in developed countries. HEV3 and HEV4 can be transmitted between humans and pigs. While all genotypes cause acute hepatitis, HEV1 and HEV2 have higher mortality rates compared to HEV3 and HEV4, especially among pregnant women.

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    There are 4 known genotypes of hepatitis E virus (HEV). HEV1 and HEV2 primarily cause large waterborne outbreaks in developing countries, while HEV3 and HEV4 typically cause sporadic cases in developed countries. HEV3 and HEV4 can be transmitted between humans and pigs. While all genotypes cause acute hepatitis, HEV1 and HEV2 have higher mortality rates compared to HEV3 and HEV4, especially among pregnant women.

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    26 views1 page

    Characteristics: Year Location N.O. of Persons Affected Putative Mode of Transmittion

    Uploaded by

    Gregório Gomes
    There are 4 known genotypes of hepatitis E virus (HEV). HEV1 and HEV2 primarily cause large waterborne outbreaks in developing countries, while HEV3 and HEV4 typically cause sporadic cases in developed countries. HEV3 and HEV4 can be transmitted between humans and pigs. While all genotypes cause acute hepatitis, HEV1 and HEV2 have higher mortality rates compared to HEV3 and HEV4, especially among pregnant women.

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    of 1

    Characteristics

    Viral discovery Geographic distribution

    HEV1
    1983 Developing countries

    HEV2
    1986 Mexico, Africa No Yes Yes Unknown No Smaller scale epidemics Young adults Not discriminatory 0.5-3% High None Not Reported Only human and non-human primates 2

    HEV3
    1995 Developed countries Yes ? ? Yes Yes No epidemics Persons 40 years of age Mostly male Not determined Not determined Yes Yes Humans Pigs 10

    HEV4
    2003 China, Taiwan, Japan Yes No No Unknown Yes Uncommon

    Food-borne transmission Fecal-oral transmission Water-borne transmission Personto-person transmission Zoonotic transmission Occurrence of epidemics Highest attack rate Gender Mortality rate Mortality among pregnant women Chronic infection Severe disease among immunocompromised Interspecies Transmission Subtypes

    No Yes Yes Yes No Common

    Young adults Male preponderance 0.5-3% High None Not Reported Only human and non human primates 5

    Young adults Not discriminatory 0.5-3% High None Not reported Humans Pigs 7

    Year 1955-1956 19781979 1986 19881989 1991 1991 1994 2004 2008
    a

    Location India Kashmir, India Mexicoa Ethiopia India Chinab Vietnam Sudanb Ugandab

    N.o. of persons affected 29300 >270 >200 >750 79000 119000 >300 >2600 >10000

    Putative mode of transmittion Waterborne Waterborne Contaminated well water After monsoon rains Contaminated river water (Ganges) Waterborne After heavy rains Safe water insufficient Substantial person-toperson

    Caused by HEV2, b Caused by HEV1

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