‫بسم ال الرحمن الرحيم‬

OVARIAN NEOPLASMS
CLASSIFICATION OF
OVARIAN NEOPLASMS
 HISTOGENETIC
CLASSIFICATION
Histologically, ovarian tumours can arise from
any of the three elements constituting the
ovary (surface epithelium, germ cell
apparatus, and ovarian stroma).
1. Epithelial Tumours
2. Germ cell tumours
3. Sex cord stromal tumours
 CLINICAL CLASSIFICATION
Clinically, ovarian tumours can be divided into:
1. Benign or malignant
tumours
2. Cystic or solid tumours
N.B.: Benign ovarian tumours are usually cystic while
malignant tumours are usually solid. N.B.: Malignant
ovarian tumours are usually primary, but may be rarely
metastatic.
 HISTOGENETIC CLASSIFICATION
1. EPITHELIAL TUMOURS OF THE OVARY
a. Serous Cystadenoma
b. Mucinous cystadenoma
c. Endometrioid tumours
d. Brenner tumour
2. GERM CELL TUMOURS
a. Teratoma
b. Dysgerminoma
c. Endodermal sinus tumour
d. Choriocarcinoma
3. SEX CORD STROMAL TUMOURS
a. Ovarian Fibroma
b. Thecoma
c Granulosa cell tumour
d. Androblastoma (Sertoli-leydig cell
1. EPITHELIAL TUMOURS
OF THE OVARY
 The commonest neoplasms arising
in the ovary.
 They are essentially benign, but
could be either border line, or
malignant tumours.
 Tumours originate from the surface
epithelium (derived
embryologically into Mullerian and
Wolffian epithelium), which can
differentiate into serous,
2. GERM CELL
TUMOURS
 Amongst the commonest ovarian
tumours seen in women <30 years
of age.
 Essentially benign, less than 2-3%
may be malignant.
 Tumours arise from totipotential
germ cells, and may therefore
contain elements of all three germ
layers (ectoderm, endoderm, and
 Germ cell tumour could be either:
 Differentiated
 Embryonic tissue (teratoma)
 Extra-embryonic tissue:
 Yolk sac: Endodermal sinus tumour

Trophoblast: choriocarcinoma
 Undifferentiated
 No evidence of differentiation into
embryonic or extra-embryonic tissue
(Dysgerminoma)
3. SEX CORD STROMAL
TUMOURS

 The least commonly encountered

tumours representing <4% of all
ovarian neoplasms.
Originate from two elements in
the gonad:
 The primitive sex cord; which
developmentally gives origin to
granulosa cells in the ovary, or
Sertoli cells in the testicle.
 The stroma of the gonad; which
differentiate into theca cells in
the ovary or Leydig cells in the
testicle.
Thank you