http://www.home-remedies-for-you.com/remedy/Cold-Sores.html http://www.sumanasinc.com/webcontent/animations/content/herpessimplex.html http://www.nhs.uk/Conditions/Mouth-ulcer/Pages/Diagnosis.aspx http://www.webmd.com/skin-problems-and-treatments/tc/cold-sores-topic-overview http://www.mayoclinic.com/health/cold-sore/DS00358/DSECTION=treatments-and-drugs http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Cold_sores http://www.herpes.org.uk/coldsores.html http://www.nlm.nih.gov/medlineplus/coldsores.html http://www.nhs.uk/conditions/Cold-sore/Pages/Introduction.aspx http://www.zovirax.com.au/What-Is-A-Cold-Sore/Stages-of-virus/ http://www.animated-teeth.com/cold_sores/t1_cold_sores.htm http://www.emedicinehealth.com/cold_sores/page5_em.htm#cold_sores_diagnosis http://emedicine.medscape.com/article/218580-overview#a0199 http://www.medicinenet.com/herpes_simplex_infections_nongenital/page6.htm#how_is_oral_herpes_diagnosed http://www.webmd.

com/skin-problems-and-treatments/understanding-cold-sores-symptoms

Skema. 2.4. Pathway Herpes Simpleks

Kontak langsung, droplet, seksual

Masuk kedalam sel host

Penetrasi kedalam DNA host

Virus berkembang biak (membelah diri) dan merangsang protein dan sentosa DNA virus dengan membentuk virus-virus baru, membran host yang lisis

Melepaskan pirofan Sel point hipotalamus

Merusak epidermis membentuk vesikel intraepidormail

meningkatkan suhu Hipertermi

kerusakan jaringan kulit

bentuk fisik berubah

kerusakan

lapisan kulit Gangguan citra tubuh

zat kimiawi/ reaksi peradangan Kerusakan integritas kulit

Nyeri

menstimulus reseptornya

Sumber : Jawet (1996)