.

&

 1900 & 1997

Metabolic Syndrome (Syndrome X)


50,000

5 1973-1997

 (2)

 ( )
Digoxin
28,000

41,000 3,300

163,000

46% /
14%
11%

parkinson
( )
61,000

2
dyskinesia
( )
73,000

Parkinsons disease

dyskinesia


( http://www.worstpills.org/)

Troglitazone (Rezulin) : severe hepatotoxicity

Rosiglitazone (Avandia) : myocardial infarct &
heart failure

Amiodarone (Cordarone) : fatal lung & liver

toxicity
Clopidogel (Plavix) : GI bleeding
Verapamil (Covera HS) : heart failure & bleeding

Alzheimer & Parkinson

Galantamine (Reminyl) : heart attack & stroke
Pergolide (Permax) : heart valve damage

Promethazine (Phenergan) : respiratory

depression
Antidepressant : suicide risk
Attention Deficit Drugs : hypertension,
tachycardia and death
Nefazodone (Serzone) : fatal liver toxicity


Rosuvastatin (Crestor) : rhabdomyolysis & kidney
damage

Celecoxib (Celebrex) : myocardial infarct & stroke
Leflunomide (Arava) : fatal interstitial pneumonia &
liver toxicity

Imantinib (Gleevec) : heart cell death & heart failure

Doxorubicin : heart damage
Iressa : fatal interstitial pneumonia

" "!

 Chemotherapy

 National Institute of Health (NIH) 2001

42%

&

Alternative Medicine

Alternative Medicine Classification

National Institute of Health (NIH) 5
1. Alternative Medical System: oriental
medicine (acupuncture, herbal med),
ayurveda, homeopathy
2. Biological Based Practices: vitamin or herbal
supplement
3. Manipulative & Body Based Therapies:
chiropractice, massage
4. Mind-Body Interventions: meditation, yoga
5. Energy Therapies: qigong, reiki

(holistic)


Harvard Medical School
1990
1997 47.3 %
1997
629
2005 70%
50


1998 13
16 (81%)
(http://www.cfpc.ca/cfp/2004/Jun/vol50-jun-editorials-2.asp)

1998-2003

Harvard Division for Research and Education in
Complementary and Integrative Therapies 2000

Acute Toxicity Test

Cytotoxicity Test

Microbial Limit

 liver function test

78 5 12

6 12

21

31

SGPT

13

19

(5.00-35.00 U/L)
Alkaline
Phosphatase

57

68

SGOT
(5.00-40.00 U/L)

(35.00-125.00)

Principle of Herbal Medicine Formulation

Leader Group : provide major action
Assistant Group : provide supporting
action
Detoxified Group : control any possible
toxicity
Carrier Group : provide target along
meridian channels


5 5



molecular biology

 (Cell Cycle)
G1 G2
proteinRNA
S DNA
M

Cell Cycle

ACE Inhibitor Activity Test


Oriental Medicine

14

 electromeridian imaging (EMI)


14
(
)
( )
5
( )
( ) & 4

(12 15 8)
5

8
(
)

27
LiShiZhen ()

Moxibustion

Shennong Materia
Medica


( )
(
)

(14 6)

17

 2
2540-2541
.
..2547
. .
..2548

.

.
pathophysiology
molecular biology