Chng 3

KT QU V THO LUN
3.1. Phn lp T dch chit butanol ca l cy sn dy, bng cc phng php sc k ct t !n silica g"l #$ phn l%p #&c ' h&p ch(t 54) *(u t +c ca ch+ng #&c ,c #nh bng cc phng php ph- nh sau. 3.2. !" #$nh "%& '()" h*p "h%' 54 /&p ch(t 54 l0 ch(t bt 10u 20ng, c3 #i41 n3ng ch5y 6 7'897': o*) ;h- <= ca h&p ch(t 54 c>ng #?c t ng cho h&p ch(t @la2on) ;h- khAi l&ng ca h&p ch(t 54 cho pic ion m/z B'C DEFG tng Hng 2Ii cJng thHc phn tK *7L/MCN'B) ;h- 'M*9OEP 20 QR;T ca h&p ch(t 54 ,u(t hiSn tTn hiSu tng Hng ca 7L cacbon, t ong #3 c3 ': cacbon thuc khung @la2on 20 '7 cacbon thuc 20o 7 gAc #Ung) ;h- '/9OEP cho th(y tTn hiSu doubl"t B,'V 20 B,MW pp1 X'/, J Y ',W /Z[ #?c t ng cho hai p oton *9B 20 *9W ca 2\ng ] 20 ba tTn hiSu tng tc 2Ii nhau th"o hS ]^_ t`i L,:: X7/, dd, J Y W,:, 7,C /Z[ 20 B,W: pp1 X'/, d, J Y W,W /Z[ #&c gn cho /97a, /9Ba 20 /9:a) bc c3 1?t tTn hiSu ca 7 p oton ano1" ic 6 :,M8 Xd, JYL,C/Z[ 20 8,MW Xbr)s[ chHng td phn tK c3 #Ung #Ji) *c tTn hiSu ca gAc #Ung utinos" ge1 glucos" X 'C',M, L8,7, LB,:, LC,', LB,:, BL,'[, X 'CC,', LC,:, LC,L, L',V, BW,M, 'L,W[ 20 ha1nos" X 'CM,C, L8,', L7,7, L7,', LC,7, 20 'W,'[ #&c gn bng sc t & gi+p ca ph- 'M*9OEP) +,ng 3.1- bA liSu ph- 'M*9 OEP ca h&p ch(t 54

C."/0n 7 M 8 : B L W V 'C 'a 7a Ma 8a :a Ba 'aa 7aa Maa 8aa :aa Baa 'aaa 7aaa Maaa 8aaa :aaa Baaa

12PT * * * * */ * * * * * */ */ * * */ */ */ */ */ */ */7 */ */ */ */ */ */M

34 "h&56n 7$"h h0! h8" 9pp:; Th<" ngh=>: T?= l=>& @23A ':B,L ':B,: 'MM,8 'MM,8 'LL,: 'LL,8 'B',M 'B',M VW,W VW,B 'B8,7 'B8,M VM,L VM,L ':B,: ':B,L 'C8,C 'C8,C '7',M '7',M ''B,M '':,8 '88,W '88,W '8W,: '8W,: '':,M ''B,8 '7',L '7',B 'C',M 'C',M L8,7 L8,M LB,: LB,: LC,' LC,' LB,: LB,C BL,' BL,' 'CC,' 'CC,W LC,: LC,: LC,L LC,L L',V L',V BW,M BW,M 'L,W 'L,V

fua sA liSu ph- 20 so snh 2Ii t0i liSu D''F c3 th4 kt lu%n ch(t 54 l0 1t @la2onoit c3 t!n l0 utin Xgu" c"tin9M9N9D 9h9 ha1nopy anosyl9X'9iB[9 9Q9glucopy anosit[) /&p ch(t n0y #$ #&c phn l%p t cy Ruta graveolens 20 tj1 th(y t ong nhiku hl thcc 2%t, c3 ho`t tTnh chAng o,y ho 20 l01 bkn th0nh 1`ch 1u D':F)

, 6

'

'

OH OH
5" 6"

HO

8 7

1 9

O
4

1' 2

'

'

O O
4" 1''' HO 2'''

5'''

CH3 4'''
3'''

6'''

6 5

10

O
1''

O HO
2" 3"

OH

OH OH

OH OH

X54[ Putin

Putin hay utosid l0 1t lo`i 2ita1in ; c3 t ong gu5 cit us Xca1, chanh, b6i)))[, chm ,anh, hoa h\", l+a 1`ch ba g3c, b`ch #0n "ucalyptus 1ac o yncha))) XkhJng n!n nhn1 2Ii 2ita1in ;;, 1t 2ita1in dong ph\ng bSnh ;"llag ", bSnh ,5y a ngo0i da 6 dn tc pn ngJ[) *hq ; l0 #nu chi ;" 1"abilitr, c3 nghsa l0 th(1 thuAc n1 t ong nh31 @la2onoid ge1 c3 h"sp" idin, utin, t o," utin, l"ucocianidol))) Putin #&c chit ,u(t t cc d&c th5o n3i t !n 20 b0o ch th0nh ch pht1) *c biSt d&c nh 2inca utin", li@aton ;, utinion, n"o utin, 1"2on :CC, utin *, sophin 'CC, utasco bin, util"1on))) #ang #&c lu h0nh t !n th t Ung) =Ii tc dung tpng cUng sHc chu #cng 20 sHc bkn th0nh 1`ch 1ao 1`ch, l01 cho th0nh 1`ch dvo 20 #0n hei hn, tpng tTnh tht1 th(u, ph\ng nga nguy c gi\n #Ht, 2w 1`ch) E?c do cha c3 kt lu%n x 0ng 2k tc dung ca n3, nhng pa ot #$ gi5i thTch c ch tc dung ca 2ita1in ;. ad "nalin, 1t ch(t ni sinh c3 tc dung tpng cUng sHc chu #cng ca 1ao 1`ch nhng chy t ong thUi gian ngn do b phn hy, utin c5n t 6 sc phn hy (y n!n sHc chu #cng ca 1ao 1`ch #&c tpng cUng Xb5o 2S 1`ch[) Putin #&c dong t ong cc t Ung h&p bi4u hiSn suy gi51 chHc npng 1`ch b`ch huyt nh chn png, d c51, bHt Ht, #au, t iSu chHng gi$n tsnh 1`ch) Q(u hiSu chHc npng cc cn t s)

Th"o zJng y, thuAc #&c dong cho bSnh nhn b tpng huyt p, 1ao 1`ch d{ 2w #Ht, #k ph\ng #Ht 1`ch 1u n$o| ,u(t huyt c(p tTnh do 2i!1 th%n| ,u(t huyt ph-i 10 khJng x nguy!n nhn 20 cn1 1u t ong 1t sA bSnh khc) *ch dong tAt nh(t 6 =iSt Oa1 l0 dong nguen hoa h\" s}n c3 6 nhiku tynh, #?c biSt l0 Thi ^jnh 20 /5i Qng) Putin (t d{ tan t ong nIc 10 t ong hoa h\", utin l`i c3 h01 l&ng cao, t !n B~) Ohn dn thUng dong hoa h\" Xb ph%n dong chTnh l0 nu hoa[ sao nh lKa cho khJ #4 c3 thy phnn '7~ X#4 b5o gu5n uAng dnn[) hi dong c3 th4 dong i!ng ho?c dong 2Ii th5o guyt 1inh, h$1 th0nh chm uAng hng ng0y, 2a v tikn l`i c3 hng 2 ngon l0nh, tpng cUng b5o 2S 1`ch

HBnh 3.2. ;h- R9Eb ca h&p ch(t :8

HBnh 3.3. ;h- '/9OEP ca h&p ch(t :8

HBnh 3.4. ;h- '/9OEP ca h&p ch(t :8

HBnh 3.5. ;h- '/9OEP ca h&p ch(t :8

HBnh 3.C.;h- 'M*9OEP ca h&p ch(t :8

HBnh 3.D.;h- 'M*9OEP ca h&p ch(t :8

HBnh 3.E.;h- 'M*9OEP ca h&p ch(t :8

HBnh 3.F.;h- QR;T ca h&p ch(t :8

HBnh 3.1G.;h- QR;T ca h&p ch(t :8

HBnh 3.11.;h- /E^* ca h&p ch(t :8

HBnh 3.12.;h- /E^* ca h&p ch(t :8

HBnh 3.12.;h- /E^* ca h&p ch(t :8

HBnh 3.13.;h- /E^* ca h&p ch(t :8

HBnh 3.14.;h- /bf* ca h&p ch(t :8

HBnh 3.15.;h- /bf* ca h&p ch(t :8

HBnh 3.1C.;h- /bf* ca h&p ch(t :8

HBnh 3.1E.;h- *Nb ca h&p ch(t :8

HBnh 3.1E.;h- *Nb ca h&p ch(t :8

HBnh 3.2G.;h- 1J phdng '/9OEP ca h&p ch(t :8

HBnh 3.2G.;h- 1J phdng 'M*9OEP ca h&p ch(t :8