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Manymutationsarecommon,infactanymutationthat occursinmorethanonepercentofthepopulationiscalledaPolymorphismmutation(U.S. NationalLibraryofMedicine,2014).Polymorphismmutationsincludeeye,hairandevenskin color.Thesemutationsusuallyhavenonegativeeffectsonthebodybutmayhaveachanceof causingdisorders.Now,thatweknowwhatgenemutationsareandhowtheyoccur,lets discovermoreaboutgenemutationsandtheiraffectsonourbodiesandproteins. Cellsofthehumanbodyaremadeupofproteinswhichgenesconstruct,makingevery proteinimportanttoeachofourcells.Geneticdisordersarefromagenemutationaffectingthe proteinsfunctionorevenstoppingtheproteinsfunctiontotally(U.S.NationalLibraryofMedicine, 2014).Genemutationsarewhatpreventsoneormoreproteinstowork(U.S.NationalLibraryof Medicine,2014).Themaininterestaboutgenemutationsisinhowtheyaffectourproteinsthat makeupourcells.Genemutationsinoneormorecellsinconsideredageneticdisorder(U.S. NationalLibraryofMedicine,2014).Mostgenemutationsthatarecommontoushumansarenot harmful,likehairbeingbrownoreyesbeingblue,butthenagainsomegenemutationsare incompatiblewithlife(U.S.NationalLibraryofMedicine,2014).Somegeneticmutationscanbe soseverethattheywillcauseanembryointhewombtodieandnevermakeittobirth.After learningtheeffectsofgenemutations,letstakeacloserlookatsomegenemutations. Sinceallgenedisordersaregenemutations,whichderivefromamalfunctioninproteins, letslookcloselyatwhattypesofgenemutationsthereareandtheireffectsonproteins.Each genemutationhasvaryingeffectsonhealthandoccurindifferentplaces.Onemutationiscalled theMissenseMutation(U.S.NationalLibraryofMedicine,2014).Thismutationiscausedfroma changeinoneDNAbasepairwhileconstructingaprotein(U.S.NationalLibraryofMedicine, 2014).TheDNAbasepairsarethebuildingblocksoftheDNAsdoublehelixandbychanging oneofthebuildingblocksitalterstheproteinsfunction.ThegameofJengabestshowsthatby removingbuildingblocks,likeaDNAbasepair,thedesiredrectangularblockbecomesatilting towerwithunfilledholesandnolongeraperfectbuilding.ThenonsenseMutationisverysimilar