ABSTRAK

NANDA AMELIA ANDARINA. Gambaran Leukosit pada Mencit yang Diinfeksi Plasmodium berghei dan Diberi Infusa Daun Papaya (Carica papaya Linn.). Dibawah bimbingan UMI CAHYANINGSIH. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian infusa daun Carica papaya Linn. terhadap persentase diferensial leukosit mencit yang diinfeksi Plasmodium berghei. Pada penelitian ini digunakan sebanyak 30 ekor mencit putih (Mus musculus albinus) jantan dan betina dengan bobot rata-rata 25 g. Penelitian ini menggunakan rancangan acak lengkap dengan tiga ulangan. Mencit dibagi dalam 5 kelompok perlakuan yaitu 1) kontrol normal (tidak diinfeksi dan diobati), 2) kontrol negatif (diinfeksi tetapi tidak diobati), 3) kelompok PA1 (infusa daun C. papaya L. dengan pengenceran 1x10-2), 4) kelompok PA2 (infusa daun C. papaya L. dengan pengenceran 1x10-4) dan 5) kelompok PA3 (infusa infusa daun C. papaya L. dengan pengenceran 1x10-6). Hasil penelitian menunjukkan bahwa persentase neutrofil pada mencit jantan cenderung lebih tinggi dibandingkan pada mencit betina dan kelompok KN. Persentase monosit dan eosinofil pada mencit jantan dan betina cenderung lebih rendah dibandingkan kelompok KN. Persentase limfosit pada mencit jantan dan mencit betina cenderung lebih tinggi dibandingkan kelompok KN. Persentase basofil tidak berpengaruh pada semua perlakuan. Kata kunci: infusa daun Carica papaya L., leukosit, malaria, mencit, Plasmodium berghei

ABSTRACT
NANDA AMELIA ANDARINA. Leucocyte Profile of Mice that Infected Plasmodium berghei and Given Papaya Leaf Infusion (Carica papaya Linn.). Under direction of UMI CAHYANINGSIH. This research was conducted to determine the effect of Carica papaya Linn. leaf infusion to the percentage of differential leucocyte mice that was infected by Plasmodium berghei. This research used laboratory animals such as male and female mice (Mus musculus albinus) that had been infected by P. berghei. Design of this research was completely randomized design with three replication. About 30 mice with an average weight of 25 g were divided into 5 groups that consists of 1) KNO (normal control), 2) KN (negative control group) was infected P. berghei, 3) PA1 group (C. papaya L. leaf infusion with dilutions of 1 x 10-2), 4) PA2 (C. papaya L. leaf infusion with dilution 1 x 10-4) and 5) PA3 group (C. papaya L. leaf infusion with 1 x 10-6). The results showed that neutrophil percentage in male mice was tend to higher than female mice and KN group. Monocyte and eosinophil percentage in male and female mice was tend to lower than KN group. Lymphocyte percentage in male and female mice was tend to higher than KN group. Basophil percentage was not influence in all groups. Keywords: leucocyte, malaria, mice, Carica papaya L. leaf infusion, Plasmodium berghei