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  • Manifestasi Klinis dan Etiologi Sindrom Koroner Akut

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    Ferdinando Baeha
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    1. Coronary artery disease (CAD) manifests clinically as myocardial ischemia which presents as unstable angina (UAP), non-ST-segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). 2. According to the WHO, 60% of deaths are caused by cardiovascular disease. The AHA reports that over 1 million Americans experience myocardial infarctions annually. In Indonesia, cardiovascular disease accounts for 26.4% of deaths and 40% of fatalities are due to myocardial infarctions. 3. The pathophysiology of atherosclerosis involves endothelial dysfunction, foam cell formation, oxidation of LDL cholesterol, inflammation, and plaque rupture over many decades as the lesions progress

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    1. Coronary artery disease (CAD) manifests clinically as myocardial ischemia which presents as unstable angina (UAP), non-ST-segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). 2. According to the WHO, 60% of deaths are caused by cardiovascular disease. The AHA reports that over 1 million Americans experience myocardial infarctions annually. In Indonesia, cardiovascular disease accounts for 26.4% of deaths and 40% of fatalities are due to myocardial infarctions. 3. The pathophysiology of atherosclerosis involves endothelial dysfunction, foam cell formation, oxidation of LDL cholesterol, inflammation, and plaque rupture over many decades as the lesions progress

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    73 views4 pages

    Manifestasi Klinis dan Etiologi Sindrom Koroner Akut

    Uploaded by

    Ferdinando Baeha
    1. Coronary artery disease (CAD) manifests clinically as myocardial ischemia which presents as unstable angina (UAP), non-ST-segment elevation myocardial infarction (NSTEMI), or ST-segment elevation myocardial infarction (STEMI). 2. According to the WHO, 60% of deaths are caused by cardiovascular disease. The AHA reports that over 1 million Americans experience myocardial infarctions annually. In Indonesia, cardiovascular disease accounts for 26.4% of deaths and 40% of fatalities are due to myocardial infarctions. 3. The pathophysiology of atherosclerosis involves endothelial dysfunction, foam cell formation, oxidation of LDL cholesterol, inflammation, and plaque rupture over many decades as the lesions progress

    Copyright:

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    of 4

    SINDROM KORONER AKUT

    Manifestasi klinis manifestasi klinis sebagai akibat iskemia miokardium

    UAP NSTEMI STEMI

    WHO 60% penyebab kematian PJK

    AHA > 1 juta orang PJK MI

    Indonesia 26,4% PJK

    40% kematian PJK

    ETIOLOGI

    Pathophysiology of Atherosclerosis

    Endothelial Dysfunction
    Foam Cells
    oxidized LDL homocysteine smoking aging hyperglycemia hypertension

    Fatty Streak

    Intermediate Fibrous Complicated Lesion Atheroma Plaque Lesion/Rupture

    35-45 yrs Endothelial injury


    nitric oxide endothelin-1 vasodilation

    45-55 yrs Lipid accumulation


    adhesion molecules (ICAM, VCAM) monocyte adhesion macrophage LDL uptake

    Inflammation

    55-65 yrs

    >65 yrs

    continued macrophage/lipid accumulation leukocyte accumulation cytokines (IL-6, TNFa, IFNg )


    4

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