>Human CCR5 MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLL NLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKAR TVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVM VICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQ VTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISV GL >Chimpanzee CCR5 MDYQVSSPIYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLL NLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKAR TVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVM VICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQ VTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISV GL >Orangutan

CCR5 MDYQVSSPTYDIDYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLL NLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKAR TVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVM VICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQ VTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISV GL >Gorilla CCR5 MDYQVSSPTYDIDYYTSEPCQKTNVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLL NLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKAR TVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVM VICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQ VTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISV GL >Mouse CCR5 MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSVTDIY LLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALK VRTVNFGVITSVVTWAVAVFASLPEIIFTRSQKEGFHYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLL VMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNRLDQA MQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNPDRASSVYTRSTGEHEV STGL >Rat CCR5 MDFQGSIPTYIYDIDYSMSAPCQKFNVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSMTDIY LFNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKLFTGIYHIGYFGGIFFIILLTIDRYLAIVHAVFAIK ARTVNFGVITSVVTWVVAVFVSLPEIIFMRSQKEGSHYTCSPHFPRIQYRFWKHFQTLKMVILSLILPLL VMVICYSGILNTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEYFGLNNCSSSNRLDQA MQVTETLGMTHCCLNPVIYAFVGEKFRNYLSVFFRKHIVKRFCKHCSIFQQVNPDRVSSVYTRSTGEQEV STGL >Zebrafish CCR5 MTEEPSTVAATKTDYSDYYNEEGDFEQPCNNGQTKAFSEVFLPTLYSIVFIIGFIGNGLVVWVLVRYRHK SNMTDVCLFNLALADLLFLVSLPFWAHNAMDEWIFGRFMCHTITGLFMIGLYASIFFMVLMTLDRYAIIV HAHSVFSRNRSTKMGLALASLVWMLSLLVSLPNIIFAKDKNETNSKISCGSDFPKDSSWMPFTYLKMNLL SLVFPLIIMIFCYSRIIPTLLSMKSQKKHKVVRLILAVVAVYFIFWTPYNIVMFLMFLQKMEYMLTCEWH

NGLSLAMQWVETIALSHCCLNPIIYAFAGEKFRGAVIKVLNDQFPMCFKQCASFTHQLSERRSSMFSRSS EISSTQIA >Chicken CCR5 MENYTDLGDMDVTTTFDYGDTAPCMGTEEKHFAANFLPPLYSLVVIFGFIGNILVVLILVKYKKLKSMTD IYLLNLAISDLLFIFSLPFWAYYAAHDWIFGDALCRILSGVYLLGFYSGIFFIILLTVDRYLAIVHAVFA LKARTVTYGILTSIVTWAVALFASVPGIVFHKTQQEHTRYTCSAHYPQEQRDEWKQFLALKMNILGLVIP MIIMICSYTQIIKTLLQCRNEKKNKAVRLIFIIMIVYFFFWAPYNICILLRDFQDSFSITSCEISGQLQK ATQVTETISMIHCCINPVIYAFAGEKFRKYLRSFFRKQIASHFSKYCPVFYADTVERASSTYTQSTGEQE VSAAL >Jerboa CCR5 MNFQVPSPTDDTDYGMAEPCQKTNVKQLAAQLLPPLYSLVFISGFVGNVLVILILISCKKLKSMTDIYLF NLAISDLLFLLTLPFWAHYAANEWVFGNIMCKLLTGLYHIGYFGGIFFIILLTIDRYLAVVHAVFALKAR TVTFGVMTSGVTWVVAIFASLPGIIFTRSQKEGFHYTCSPHFPNRQYHFWKNFQTLKMIILGLVLPLLVM VICYSGILHTLLRCRNEKKRHRAIRLIFAIMIVYFLFWTPYNIVLFLTTFQMFFGLNNCDNSNRLDQAIQ VTETLGMTHCCINPVIYAFVGEKFRKYLFVFFQKHITKCFCKHCPIFQQDSPEHVSSVYTRSTGEQEVSV GL >Hamster CCR5 MDLQVSSPSYLYDMDYSMSVPCQKTNVKQIAGQLLPPLYSLVFIFGFVGNMLVILILISCKKLKSMTDIY LFNLAISDLLFLFTLPLWAHYAANEWVFGGIMCKLFTGIYHIGYFGGIFFIILLTVDRYLAIVHAVFALK ARTVTFGVMTSGVTWVAAVLASVPEIIFTRSQKEGLHHSCSPHFPHTQYRFWKSFQTLKMVILSLVLPLL VMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLITFQEFFGLNNCTSSNRLDQA MQVTETLGMTHCCINPVIYAFVGEKFRNYLSVFFQKHIVKRFCKHCPIFQQNNLDRMNSVCTRSTGEQDI STGL >Dove CCR5 MDIMENHTIDLSDWPLTTEFEYSDSTPCPGTEEKHFAANLLPPLYSLVVIFGLTGNMLVVLILVKYKRLK SMTDIYLLNLAISDLLFIFSLPFWAYYAAHDWIFGDALCRILSGVYLLGFYSGIFFIILLTLDRYLAIVH AVFALKARTVTYGILTSVVTWAVSICGILTSVVTWAVAICASVPGIVFHKSQKEHSRYTCSAHYPSEQRD LWKQFLTLKMNILGLVIPMLIMICSYTQIIKTLLQCRNEKKHKAVRLIFIIMIVYLLFWAPYNICILLRD FQGIFSITTCEGNGQLHKATQVTETISMIHCCINPVIYAFAGEKFRKYLHSFFRKQIAFHFSKYCPVFYV DTAERASSTYTQSTGEQEVSAAL >Dog CCR5 MNYQTSTPYYDIDYGTSEPCQKVNVRQIAARLLPPLYSLVFIFGFVGNVLVVLILIDCKKLKSMTDIYLL NLAISDLLFLLTIPFWAHYAADQWTFGNKMCQLLTGLYYIGFFTGNFFIILLTMDRYLAIVHAVSASKAR TVTFGVVTSGIAWVVAVLASFPRIIFTRSQKEGSRFTCSPHFPPSQHHFWKNFQALKMSVLGLILPLLVM IIGYSAILKTLLRCRNEKKRHKAERLIFVIMIVYFLFWAPYNIVLLLSTFQEFFGLNNCNSSNRLDQAMQ ITETLGMTHCCINPIIYAFVGEKFRRYLSLFFRKHIARRFCKCCPIFQGELPDRVSSVYTRSTGEQEISV AL >Cat CCR5 MDYQATSPYYDIEYELSEPCQKTDVRQIAARLLPPLYSLVFISGFVGNLLVVLILINCKKLRGMTDVYLL NLAISDLLFLFTLPFWAHYAANGWVFGDGMCKTVTGLYHVGYFGGNFFIILLTVDRYLAIVHAVFALKAR TVTFGAVTSAVTWAAAVVASLPGCIFSRSQKEGSRFTCSPHFPSNQYHFWKNFQTLKMTILGLVLPLLVM IVCYSAILRTLFRCRNEKKKHRAVKLIFVIMIGYFLFWAPNNIVLLLSTFPESFGLNNCSSSNRLDQAMQ VTETLGMTHCCINPIIYAFVGEKFRSYLLVFFQKHIARRFCKHCPVFQGKALDRASSVYTRSTGEQEISV GL >Cow CCR5 MDYQTSTPLYDIDYGMSEPCQKLNVRQIAARLLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLL

NLAISDLLFIITIPFWAHYAADQWVFGNTMCQLFTGFYFIGYFGGIFFIILLTIDRYLAIVHAVFALKAR TVTFGAATSVVTWVVAVFASLPGIIFTKSQKEGSRHTCSPHFPSSQYHFWKNFQTLKIVILGLVLPLLVM IVCYSGIIKTLLRCRNEKKKHKAVRLIFVIMIVYFLFWAPYNIVLLLSTFQEFFGLNNCSGSNRLDQAMQ VTETLGMTHCCINPIIYAFVGEKFRNYLLRFFRKYFASRFCKGCPVFQGEAPERVSSVYTRSTGEQEISV GL >Cichlid CCR5 MDETTETDFTFSLNLTESSLFQGFSTPPTENSSAYSSEYTTDYYYDPTMFDEFEPCVYTRHGATFLPAIY IIFFLLGVLGNSLVFWVITFGARLRTMTDVCLLNLAIADLLLVCCLPFLAHQARDQWVFGDAMCKIVLGI YHIVFYCGIFFITLMSIDRYLAIVHAVCAMRARTRSFGMIAAAVTWGAGFLASFPDLIFLQEQRNASGQH TCYPGFPGVSSSLHFWQVFSIAKMNIVGLLIPIIILGFCYSQIIWRLLNSQSSKKQAIRLVVIVVAIFFC CWIPYNIASLARALELKHRFLDCGHSKAVRLALQITEAIAYSHSCLNPILYVFVGEKFRRHLLRMINRSP CRLCQLIKVFIPQDRISTSVYSQTTSVDERSTAM >Horse CCR5 MDYQTTSPFYDIDYGMSEPCQKTDVRQIAARLLPPLYSLVFISGFVGNLLVALVLIKCKKLKSMTDIYLL NLAISDLLFLLTLPFWAHYAAHQWELGNTMCRLLTGLYFIGFFSGIFFIILLTIDRYLAIVHAVFALKAR TVTFGLMTSGVTWAVAVFVSLPGIIFTKSQKEGTRFTCSPHYPPSQYHFWRNFQALKMTILGLVLPLLVM IICYSGILKTLLRCRNEKKRHKAVRLIFVIMIMYFLFWAPYNIVLLLSTFQKSFGLDQCSSSNRLDQAMQ VTETLGMTHCCINPVIYAFVGEKFRNYLLGYFRKHIVRRFCKSCPVFQGEAPKRVNSIYTGSTGEQEISV GL >Frog CCR5 MNHTPAVIEDLSTLFTNYDDYTPCDKDEIKQKAAKFLVPVYIFVFLLGIIGNALVIIILIKYKKLRNMTD IYLLNLAISDLLFVISLPFWAYYVTNDWAFGDALCKLFSGLYLTGFYGASFFIILLTLDRYLAIVHAIFA MKVRTVKFSISTSVFLWGIAIFFSLPGFIFYKAEKQAGNWTCSPYYTTSWKLIFTFMMTILGLFIPLVVM LFCYSRIIYTLLRCRSEKKKHKAVKLIFIIMVVFFIFWMPYNIVYLMHTFQDPESPNACETSNKLDEAVQ WTEAISYFHCCLNPIIYAFVGEKFRKYLFIFLQKVFPNWCLCSSLFSTHMSLHERHSSLYTPSTGEHDIS AVL