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    40 views14 pages

    Antibiotik - Penghambat Sintesis Asam Nukleat

    Uploaded by

    Muhammad Reza Basri

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 14

    Klasifikasi

    Finkel, Richard., Clark, Michelle A. Cubeddu, Luigi X., 2009, Lippincott's Illustrated Reviews: Pharmacology, 4th Edition, LWW, USA

    Fluorokuinolon

    http://www.thekanjifoundrypress.com/f.html

    Fluorokuinolon

    http://www.activtox.com/hepatotoxicity/str.php

    Mekanisme Kerja

    Finkel, Richard., Clark, Michelle A. Cubeddu, Luigi X., 2011, Lippincott's Illustrated Reviews: Pharmacology, 5th Edition, LWW, USA

    Molecular Biology DNA Replication

    Tahap Inisiasi Replikasi DNA


    DNA Supercoiling dapat tercipta akibat aktivitas DNA helikase

    Figure 5-21 Molecular Biology of the Cell ( Garland Science 2008)

    Spektrum Kuinolon

    Finkel, Richard., Clark, Michelle A. Cubeddu, Luigi X., 2011, Lippincott's Illustrated Reviews: Pharmacology, 5th Edition, LWW, USA

    Spektrum Kuinolon

    Finkel, Richard., Clark, Michelle A. Cubeddu, Luigi X., 2011, Lippincott's Illustrated Reviews: Pharmacology, 5th Edition, LWW, USA

    Inhibitor Folat

    Finkel, Richard., Clark, Michelle A. Cubeddu, Luigi X., 2011, Lippincott's Illustrated Reviews: Pharmacology, 5th Edition, LWW, USA

    Mekanisme Kerja

    Spektrum Kotrimoksazol

    Finkel, Richard., Clark, Michelle A. Cubeddu, Luigi X., 2011, Lippincott's Illustrated Reviews: Pharmacology, 5th Edition, LWW, USA

    Efek Samping

    Finkel, Richard., Clark, Michelle A. Cubeddu, Luigi X., 2011, Lippincott's Illustrated Reviews: Pharmacology, 5th Edition, LWW, USA

    Mekanisme Resistensi
    a. Menurunkan permeabilitas membran terhadap obat: adanya pompa effluks akan menurunkan konsentrasi molekul obat dalam sel b. Perubahan enzim DNA gyrase (untuk Fluorokuinolon) c. Perubahan struktur enzim dihidrofolat reductase; umumnya pada bakteri gram negatif (untuk trimetoprim)

    Suggested Readings

    Tjay dan Rahardja, 2003, Obat-Obat Penting, Edisi 5, Elex Media Komputindo, Jakarta Katzung, B.G. (Ed.), 2007, Basic and Clinical Pharmacology, 10th Ed., Lange, New York Neal, 2005, At a Glance: Farmakologi Medis, EMS, Jakarta Janeway, 2005, The Immune System, 2nd Ed., Garland Science, New York Finkel, R., Clark, M. A., Cubeddu, L.X., 2009, Lippincott's Illustrated Reviews: Pharmacology, 4th Edition, LWW, Philadelphia

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