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  • Module 2 - Connective Tissue Cells

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    Sam Tagarda
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    This document describes the cellular characteristics and roles of resident and wandering cells found in connective tissue. Resident cells such as fibroblasts, chondroblasts and osteoblasts synthesize proteins of the extracellular matrix. Wandering cells, including macrophages, mast cells, lymphocytes, and neutrophils, have roles in immune functions like phagocytosis, antigen presentation, and cytokine secretion. Fibroblasts synthesize collagen and elastin. Macrophages phagocytose foreign substances and present antigens. Lymphocytes and plasma cells are involved in immune responses.

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    Histology

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    This document describes the cellular characteristics and roles of resident and wandering cells found in connective tissue. Resident cells such as fibroblasts, chondroblasts and osteoblasts synthesize proteins of the extracellular matrix. Wandering cells, including macrophages, mast cells, lymphocytes, and neutrophils, have roles in immune functions like phagocytosis, antigen presentation, and cytokine secretion. Fibroblasts synthesize collagen and elastin. Macrophages phagocytose foreign substances and present antigens. Lymphocytes and plasma cells are involved in immune responses.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    16 views12 pages

    Module 2 - Connective Tissue Cells

    Uploaded by

    Sam Tagarda
    This document describes the cellular characteristics and roles of resident and wandering cells found in connective tissue. Resident cells such as fibroblasts, chondroblasts and osteoblasts synthesize proteins of the extracellular matrix. Wandering cells, including macrophages, mast cells, lymphocytes, and neutrophils, have roles in immune functions like phagocytosis, antigen presentation, and cytokine secretion. Fibroblasts synthesize collagen and elastin. Macrophages phagocytose foreign substances and present antigens. Lymphocytes and plasma cells are involved in immune responses.

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    of 12

    CONNECTIVE TISSUE:

    Cellular Characteristics
    and roles
    Resident Cells Wandering/transient
    Cells
    Fibroblasts,
    chondroblast,
    osteoblast, odontoblast
    Macrophages
    Adipose cells
    Mast cells
    Undifferentiated
    mesenchymal cells
    Lymphocytes
    Plasma Cells
    Neutrophils
    Eosinophils
    Basophils
    Monocytes

    Fibroblasts

    Synthesize collagen,
    elastin, GAG,
    proteoglycans,
    multiadhesive
    glycoproteins
    Involved in
    production of growth
    factors
    Macrophages

    Secretion of cytokines &
    other molecules
    Phagocytosis of foreign
    substances & bacteria
    Antigen processing and
    presentation to other cells
    Constitute the MPS
    Characterized by irregular
    surface w/ pleats,
    protrusions, indentations,
    a well developed golgi
    complex, many lysosomes,
    a prominent RER
    Adipose Cells

    Specialized for
    storage of neutral
    fats or for the
    production of heat
    A.k.a. fat cells
    Mast Cells and basophils

    Oval to round
    Cytoplasm filled
    w/ basophilic
    secretory granules
    Small, spherical
    nucleus centrally
    located
    Liberation of
    pharmacologically
    active molecules
    (eg, histamine,
    heparin)
    Pericytes

    A.k.a.
    adventitial/perivascular
    cells
    Found around capillaries
    and venules
    Surrounded by basal
    lamina material
    Typically wrapped, at
    least partially, around
    capillary
    Nucleus takes on a shape
    similar to endothelial cells
    (flattened but curved)
    Lymphocyte

    Production of
    immunocompetent
    cells
    Have a thin rim of
    cytoplasm
    surrounding a
    deeply staining,
    heterochromatic
    nucleus
    Smallest of the
    free cells in the CT
    Most numerous in
    lamina propria of
    the GI tracts
    Plasma Cells

    Production of antibodies
    Relatively large, ovoid,
    with a considerable
    amount of cytoplasm
    Cytoplasm -> basophilic
    due to extensive rER
    Nucleus spherical &
    typically
    offset/eccentrically
    positioned, exhibit large
    clumps of peripheral
    heterochromatin
    alternating w/ clear areas
    of euchromatin
    Neutrophils

    Phagocytosis of
    foreign substances,
    bacteria
    Most common
    WBC
    Larger than RBCs
    Multilobed
    nucleus

    Eosinophils

    Participation in
    allergic &
    vasoactive
    reactions
    Modulation of
    mast cell activities
    & the
    inflammatory
    process
    Nuclei typically
    bilobed
    Monocytes

    Precursors of the
    cells of the MPS
    Largest of the
    WBCs
    Travel from bone
    marrow to body
    tissues, where they
    differentiate into
    various phagocytes
    of the MPS

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