ABSTRAK

RASIONALITAS PENGGUNAAN CIPROFLOXACIN

DI KECAMATAN ILIR TIMUR I
KOTA PALEMBANG
(Muhammad Habibi Nst, Januari 2014, 74 Halaman)
Fakultas Kedokteran Universitas Sriwijaa
Latar Belakang: !i"or#lo$a%in meru"akan sala& satu anti'iotik an( 'eredar luas
di )ndonesia* !+! (Center for Disease Control and Prevention) men(estimasi
'a&wa setia" ta&unna sekitar ,0 juta dari 1,0 juta "asien tela& direse"kan
anti'iotik an( se'enarna tidak di"erlukan* Ketidakte"atan "erese"an terse'ut
da"at mene'a'kan tidak ter%a"aina tujuan tera"i, menin(katna Adverse Drug
Reaction (-+.) "ada kom'inasi %i"ro#lo$a%in den(an o'at/o'at tertentu,
menin(katna resistensi anti'iotik, serta menin(katna an((aran 'iaa
"en(o'atan* 0amun, 'elum ada data s"esi#ik an( menilai rasionalitas
"en((unaan %i"ro#lo$a%in*
Metode: Studi "en((unaan o'at melalui analisis rese" o'at di )nstalasi Farmasi
.uma& Sakit Umum 1oe&ammad Hoesin 2alem'an(, -"otek Se&at 3ersama dan
-"otek 4ra&a S"esialis an( dilakukan selama 5 'ulan* +ida"atkan 600
"erese"an an( men(andun( %i"ro#lo$a%in didalamna an( memenu&i jumla&
sam"el an( di'utu&kan dalam "enelitian ini*
a!"l:+ari 600 sam"el terda"at 26 sam"el (4,5557) distri'usi dosis "en((unaan
%i"ro#lo$a%in an( tidak rasional, se'anak 61 sam"el (10,1767) distri'usi
#rekuensi "em'erian %i"ro#lo$a%in an( tidak rasional, se'anak ,25 sam"el
(8,,,7) distri'usi lama "em'erian %i"ro#lo$a%in tidak rasional, se'anak 28
sam"el (2,9,17) an( 'erinteraksi se%ara #armakodinamik siner(i adisi, 8 sam"el
(0,99,7) an( 'erinteraksi se%ara #armakodinamik anta(onis, dan 185 sam"el
(19,8777) an( 'erinteraksi se%ara #armakodinamik "otensiasi*
Ke!"#$%lan: :in((ina an(ka kejadian interaksi #armakodinamik "otensiasi
"en((unaan %i"ro#lo$a%in den(an o'at lain dan masi& terda"at "en((unaan
%i"ro#lo$a%in an( tidak te"at se%ara dosis, #rekuensi "em'erian, lama "em'erian,
serta %ara "em'erian*
Kata K%n&": -nti'iotik, !i"ro#lo$a%in, )nteraksi ;'at, .asionalitas
2alem'an(, Januari 2014
1en(eta&ui,
2em'antu +ekan ) 2em'im'in( )
dr' M%t"ara B%d" A()ar* SU* MMedS& dr' S%to#o Tan("l M'S&* S$'FK'
NIP' +,-. /+/0 +,12/2 + //+ NIP' +,3,+.+45+,0-/2 + //+
v
ABSTRACT
RATIONAL OF USE CIPROFLOXACIN
AT KECAMATAN ILIR TIMUR I
KOTA PALEMBANG
(Muhammad Habibi Nst, Januar 2014, 74 "a(es)
1edi%al Fa%ult o# Sriwijaa Universit
Background: Ciprofloxacin is one antibiotic that is idel! circulated in
"ndonesia# CDC (Center for Disease Control and Prevention$ estimates about %&
million of the '%& million patients each !ear have been prescribed unnecessar!
antibiotics# "naccurac! in prescribing antibiotics can lead to failure to achieve the
goals of therap!, increased Adverse Drug Reaction (ADR$ of ciprofloxacin in
combination ith certain drugs, increasing antibiotic resistance, and increased
medical budget# Hoever, there is no specific data that assess the rationalit! of
the use of ciprofloxacin#
Methods: A Drug (tili)ation *tud! use of prescription drugs through anal!sis at
"nstalasi +armasi R*MH, Apote, *ehat -ersama and Apote, .raha *pesialis
hich has been done for / months# "t obtained 0&& prescriptions containing
ciprofloxacin for samples in this stud! #
Results: 1f the 0&& samples had been found about 20 samples (3#///4$
irrational dose distribution of using ciprofloxacin, a total of 0' samples
('&#'504$ about irrational fre6uenc! distribution of ciprofloxacin administration,
as man! as %2/ samples (7%#%4$ irrational distribution of the duration of
ciprofloxacin, a total of 27 samples (2#8%'4$ that interact pharmacod!namic
s!nerg! addition, 7 samples (&#88%4$ that antagonistic pharmacod!namic
interaction, and '7/ samples ('8#7554$ that interact pharmacod!namic
potentiation #
Conclusion: 9here are high incidence of the use of ciprofloxacin potentiation
pharmacod!namic interaction ith other drugs and there are improper use of
ciprofloxacin in the dose, fre6uenc! of administration, duration of administration,
and mode of administration#
Keywords: Antibiotics, Ciprofloxacin, Drug "nteractions, Rationalit!
2alem'an(, Januari 2014
1en(eta&ui,
2em'antu +ekan ) 2em'im'in( ))
dr' M%t"ara B%d" A()ar* SU* MMedS& dr' T)eodor%! MMedS&
NIP' +,-. /+/0 +,12/2 + //+ NIP' +,4/ /,+- +,1,/2 + //-
vi