Neoplasia- Why should you give a *&%#?

What is it?
Lay term of tumor conveys usual connotations ie a new growth or mass
Tumor= swelling, neoplasm= new growth of cells
Definition revolves around these features:
Monoclonal proliferation of cells with specific mutations
Excessive and unregulated growth of these cells, often at the expense of
surrounding normal tissue
Differentiation
Tumors are often graded as to how
closely they resemble the normal parent
tissue that they are derived from. G1- ok I
know where this tissue came from , G5-
whoa what type of tissue is this?
Well-differentiated cells are very
similar in appearance and architectural
arrangement to normal tissue of that
organ
Poorly-differentiated refers to
tumors that show only minimal
resemblance to the normal parent tissue
they are derived from.
Anaplastic means the tumor shows no
obvious similarity to its parent tissue,
usually associated with aggressive
behavior
Differentiation provides clues to the
clinical aggressiveness of the tumor
More differentiated, more aggressive more malignant; more
mutations
Can predict responsiveness to therapies (PR/ER)
B9 vs Malignant



Surgical path- know the histology/ move to IHC/
then move to genetic testing of the tissue.