Professional Documents
Culture Documents
PATHOPHYSIOLOGY
a. Schematic Diagram
Modifiable Factors
-Diabetic Mellitus
-Hypertension
-Increase Protein and
Cholesterol Intake
-Smoking
-Use of analgesics
Non-Modifiable Factors
-Hereditary
-Age greater than 60 years
old
-Gender
-Race
Decreased renal blood flow
Primary kidney disease
Damage from other diseases
Urine outflow obstruction
Decreased
glomerular filtration
Serum
Creatinin
e
BUN
Hypertrophy of
remaining nephrons
Inability to
concentrate urine
Loss of Sodium
in Urine
Dilute
Polyuri
a
Dehydration
Further loss of
nephron function
Loss of nonexcretory
renal function
Failure to convert
inactive forms of
calcium
Calcium
absorption
1
Failure to produce
eryhtropoietin
Impaired insulin
action
Production of
lipids
Immune
disturbances
Disturbances in
reproduction
Hyponatremia
Anemia
Pallor
Erratic blood
glucose
levels
Advanced
atherosclerosis
Delayed
wound
healing
Infection
Libid
o
Infertility
2a
Chronic Kidney Disease
Excretion of
nitrogenous
waste
Uremia
Decreased
sodium
reabsorption in
tubule
Water Retention
Hypertension
Heart Failure
Edema
Decreased
potassium
excretion
Hypocalcemia Osteodystrophy
BUN,
Creatinine
Uric Acid
Proteniuria
Peripheral
nerve
changes
Pericarditi
s
CNS
changes
Pruritu
s
Altered Taste
Bleeding
Tendencie
s
Hyperkalemia
Decreased
phosphate
excretion
Hyperphosphatemia
Decreased
calcium
absorption
Hypocalcemia
Hyperparathyroidism
Decreased
potassium excretion
Increased
potassium
Decreased
hydrogen
excretion
Metabolic
acidosis
1
2a
Loss of excretory
renal function