Vitamin E is naturally occuring antioxidant.

It is
essential for normal reproduction hence
known as anti-sterility vitamin.
Vitamin E is the name given to group of
TOCOPHEROLS.
Eight different tocopherols.
Alpha tocopherol is the most important.
Tocopherols are derivatives of 6-Hydroxy
chromane ring.
The antioxidant property is due to chromane
ring.
Tocopherols
Amount absorbed is dependent on fat intake
Incorporated into micelles
Requires bile and fat digesting enzymes
Transported via chylomicrons to the liver
Transported via VLDL, LDL, HDL from the liver
Lipophilic,found concentrated in areas where
fat is found(adipose tissue) and liver.
Excreted via bile and urine.
Plant oils are the rich source.
Margarine
Nuts and seeds
Actual amount is dependent on harvesting,
processing, storage and cooking

8 mg/day for women and 10mg/day for men
Average intake meets RDA
VITAMIN E IS THE MOST IMPORTANT
NATURAL ANTIOXIDANT.
Vitamin E appears to be the first line of
defense against peroxidation of
polyunsaturated fatty acids (PUFA) contained
in cellular and sub cellular membrane
phospholipids.
Redox agent
Vitamin E is able to donate electron to
oxidizing agent
Protect the cell from attack by free radicals
Production is normal result of cell metabolism
and immune function
Destructive to cells; set off a chain reaction
Lipid peroxidation

Increases the synthesis of heme by enhancing
the activity of enzymes delta-aminolevulinic
acid(ALA) and ALA dehydratase.
Required for cellular respiration(believed to
stablize coenzyme Q)
Works in association with vitamin C,beta
carotenes,to delay the onset of cataracts.
Prevents oxidation of VLDL(Oxidized form is
atherogenic)
Premature infants
People with fat malabsorption
Cystic fibrosis, celiac disease, liver disease
Chronic steatorrhea and
abetalipoproteinemia,

Low selenium intake