Hepatobiliary Physiology

Anatomi Hepatobiliar

Anatomi Hepar

Anatomi Hepar

Anatomi Hepar

Anatomi Hepar

Sirkulasi Hepatik

Sirkulasi Hepatik

Sirkulasi Hepatik

20% dari Cardiac Output masuk ke dalam hepar

Darah masuk dari:

dua pertiga dari vena porta

Sepertiga dari vena hepatika

Oksigen didapat dari

Setengah dari vena porta

Setengah dari vena hepatika

Darah masuk melalui

Arteri hepatika
Vena porta
Keluar melalui
Vena hepatika

Saluran lain
selainpembuluh darah:
duktus biliaris

Triad Porta

Hepatic Circulation

The portal system is a train

between the gut and the liver

Blood enters via the portal triad

Bile exits via the portal triad

Portal Triad

Hepatic Lobule

Hepatic Lobule

Hepatic Lobule

Hepatic Vein

Hepatic Circulation

Blood enters via the portal triad

Blood is distributed to lobules

Blood exits via the hepatic veins

Bile exits via the portal triad

Gallbladder

Bile doesnt go
directly to the gut

Bile collects in
the Gallbladder

Here, bile becomes

more concentrated

Bile is then excreted

when it is needed

Gallbladder Histology

Hepatobiliary Anatomy

To understand how the bile gets to

the gut, we need to remember
hepatobiliary development

Hepatobiliary Anatomy

Hepatobiliary Drainage

Pancreas Head

Lesser Sac / Pancreas

Pancreatic Ducts

Hepatic Anatomy

Liver Function

Liver Function

Blood Extracellular Matrix

Detoxification and Blood Filtration
Reservoir

Energy

Reticuloendothelial System
Amino Acids, Lipids, Carbohydrates
Regulation of Blood Glucose
Production of Backup Carbon Energy Sources

Bile Production

Bile

Bile is composed of:

Bile Acids
Cholesterol
Lecithin

Of course, there is also NaCl and H2O

Bile Secretion

Bile Secretion

Gallbladder Function

Bile is produced continuously

It is collected in the Gallbladder

It is secreted in response to
Cholecystokinin (CCK)

It is then introduced to the Duodenum

Enterohepatic Circulation

Enterohepatic Circulation

This circulation facilitates:

Excretion of lipophilic waste
Absorption of lipophilic nutrients
Mixing of chyme

Pancreatic Secretion

Pancreatic Secretion

Pancreatic Secretion

Control of Pancreatic Secretion

Hepatobiliary Secretion

The Duodenum
Receives Chyme from the Stomach
Receives Juice from the Liver + Pancreas
Begins Digestion and Absorption

Questions?