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African medicinal plants may stop tumor growth from multi-drug resistant cancers: Research
by David Gutierrez, staff writer
(NaturalNews) Traditional African medicinal plants may contain naturally occurring compounds that
effectively kill drug-resistant cancers, according to research conducted by Victor Keute of the University of
Dschang in Cameroon and Thomas Efferth of Johannes Gutenberg University Mainz in Germany.
"The active substances present in African medicinal plants may be capable of killing off tumor cells that are
resistant to more than one drug," Efferth said. "They thus represent an excellent starting point for the
development of new therapeutic treatments for cancers that do not respond to conventional chemotherapy
regimens."
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African medicinal plants may stop tumor growth from multi-drug resistant cancers: Research
6/27/13 5:14 PM
risk and magnitude of the often severe side effects associated with cancer treatments.
One of the things that makes drug-resistant cancers so difficult to deal with is that cancers can evolve drug
resistance through several separate mechanisms. In their research, Efferth and Kuete are testing the African
plants against a cancer cell line that uses three separate drug-resistance strategies. The first, known as
transporter-mediated resistance, occurs when a substance called P-glycoprotein causes drugs to be
prematurely flushed out of cancer cells. The second, tumor-suppressor-gene-mediated resistance, results
from a mutation to protein p53 that makes cancer cells enormously aggressive and resistant. The third,
oncogene-mediated resistance, occurs when the epidermal growth factor receptor (EGFR) signals cancerous
tumors to accelerate their growth, overwhelming the capacity of drugs to kill them.
Yet the researchers have already discovered substances from the African plants that are effective against all
of these strategies. They are now further testing these chemicals in the hopes of developing them into
effective drugs.
"The benzophenones investigated are potentially cytotoxic substances that need to be more extensively
investigated with the aim of developing new cancer drugs that are effective against susceptible and resistant
cancers," they wrote recently in the journal Phytomedicine.
"We are now looking for substances that can both break down tumor resistance and not produce side
effects," Efferth said.
Sources for this article include:
http://www.uni-mainz.de/presse/16481_ENG_HTML.php
http://www.eurekalert.org/pub_releases/2013-06/jgum-sfa061013.php
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