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Ig-E mediated
anaphylaxis
Release of mediators from mast
cells and basophils
Histamine
PGD2
LTC4
Tryptase
leads to the clinical presentation of
anaphylaxis
Stimulation of H1 and H2
receptors
Profound vasodilation
Decrease in systemic vascular
resistance with hypotension
Tachycardia
Flushing
Increase in bronchial and GI
smooth muscle contraction and
glandular secretion
Tryptase
Phathogenic mechanism
and aetiology of
anaphylaxis
I . IgE mediated anaphylaxis ( 60 %)
V. idiopathic anaphylaxis
Exercise
Catamenial anaphylaxis
Idiopathic anaphylaxis
Diagnosis of
anaphylaxis
Symptom presentation
Differential diagnosis
All causes of respiratory obstruction and
vascular collapse including :
Pulmonary embolism
Cardiac arrythmias
Cardiac tamponade
Myocardial infarction
Sepsis
Seizure disorders
Insulin reaction
Additional tests
Tryptase
Specific IgE antibodies are
raised : SPT, RAST
Provocation tests ---- RAST (-)
Management of
anaphylaxis
Management of
anaphylaxis