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  • Antimycobacterials Literature Survey 2004 To 2000

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    Literature survey Journals covered Prous Drug Data reports Vol 22 2000 to 2004 Vol 26 (3) Classified as the following 1. Natural products and analogs. 2. Synthetic molecules with target. 3. Synthetic molecules without target.

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    Antimycobacterials Literature survey 2004 to 2000

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    Literature survey Journals covered Prous Drug Data reports Vol 22 2000 to 2004 Vol 26 (3) Classified as the following 1. Natural products and analogs. 2. Synthetic molecules with target. 3. Synthetic molecules without target.

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    2K views20 pages

    Antimycobacterials Literature Survey 2004 To 2000

    Uploaded by

    santosh_nandan
    Literature survey Journals covered Prous Drug Data reports Vol 22 2000 to 2004 Vol 26 (3) Classified as the following 1. Natural products and analogs. 2. Synthetic molecules with target. 3. Synthetic molecules without target.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 20

    Literature survey

    Journals covered Prous Drug Data reports

    Vol 22 2000 to 2004 Vol 26 (3)

    Classified as the following


    1. Natural products and analogs.
    2. Synthetic molecules with target.
    3. Synthetic molecules without target.

    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    2005- SRN
    Final analysis
    MIC Intracellu
    Compds Target MICtb Ic50 Efficacy Tox
    mycobacteria lar
    Natural products
    Tuberactomycin analogs No target 0.2-6.25 N N N
    Erythromycin analog Ribosome 2-Jan 0.4 -4 N N
    Capuramycin analogs MraY 1 0.5-8 100nm N N
    Synth. with target
    7000 fold vero
    pteridine analogs DHFR <0.13 NA 1nM N N
    cells
    Thiolactomycin analog FabH 17
    Fluorenes Inh A 4 160nM
    Clofazimine analog MOA known 0.5
    Mycobactin analog Fe chelator
    Synth. without target
    10fold vero
    Purines unknown 0.78
    cells
    equiv to No acute tox
    Tetracyclic pyrimidines unknown 0.1
    SM 1.5g I.p /po
    Ec50
    Hydrazones unknown 6.25
    =0.65
    Janssen quinolines unknown 0.01
    serine
    threonine
    Quinoxalines kinases, 2
    2005- SRN TNF, Hiv,
    HCV etc

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